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Structure of the secretory immunoglobulin A core 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:  Kumar N.;  Arthur C.P.;  Ciferri C.;  Matsumoto M.L.
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/28
dimer  immunoglobulin receptor  oligomer  pentamer  secretory component  secretory immunoglobulin  tetramer  unclassified drug  antibody  immune response  immunity  pathogen  physiological response  protein  secretion  antigen antibody complex  antigen binding  Article  cryoelectron microscopy  human  immune reconstitution  immunity  immunoglobulin structure  oligomerization  priority journal  transcytosis  
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Yuan M.;  Wu N.C.;  Zhu X.;  Lee C.-C.D.;  So R.T.Y.;  Lv H.;  Mok C.K.P.;  Wilson I.A.
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  epitope  neutralizing antibody  virus hemagglutinin  virus spike protein  angiotensin converting enzyme 2  coronavirus receptors  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  neutralizing antibody  spike glycoprotein, SARS-CoV  spike protein, SARS-CoV-2  virus antibody  virus antigen  virus receptor  antibody  antigen  chemical binding  crystal structure  protein  respiratory disease  viral disease  virus  amino terminal sequence  antibody isolation  antigen binding  antigenicity  Article  binding affinity  binding site  conservation biology  controlled study  coronavirus disease 2019  cross reaction  cryoelectron microscopy  crystal structure  enzyme linked immunosorbent assay  epidemic  glycosylation  human  hydrophobicity  immune response  in vitro study  in vivo study  light chain  nonhuman  priority journal  protein conformation  protein domain  protein interaction  protein localization  protein structure  protein targeting  receptor binding  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  antibody affinity  Betacoronavirus  binding site  chemistry  immunology  metabolism  molecular model  SARS coronavirus  X ray crystallography  Coronavirus  SARS coronavirus  Amino Acid Sequence  Antibodies, Neutralizing  Antibodies, Viral  Antibody Affinity  Antigens, Viral  Betacoronavirus  Binding Sites  Cross Reactions  Crystallography, X-Ray  Epitopes  Models, Molecular  Peptidyl-Dipeptidase A  Protein Conformation  Protein Domains  Protein Interaction Domains and Motifs  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus  
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  ElTanbouly M.A.;  Zhao Y.;  Nowak E.;  Li J.;  Schaafsma E.;  Le Mercier I.;  Ceeraz S.;  Lines J.L.;  Peng C.;  Carriere C.;  Huang X.;  Day M.;  Koehn B.;  Lee S.W.;  Morales M.S.;  Hogquist K.A.;  Jameson S.C.;  Mueller D.;  Rothstein J.;  Blazar B.R.;  Cheng C.;  Noelle R.J.
收藏  |  浏览/下载：57/0  |  提交时间：2020/07/28
cell protein  interferon  kruppel like factor 2  T lymphocyte receptor  unclassified drug  V type immunoglobulin domain containing suppressor of T cell activation protein  B7 antigen  Dies1 protein, mouse  lymphocyte antigen receptor  membrane protein  monoclonal antibody  VSIR protein, human  biological development  cell  gene expression  heterogeneity  homeostasis  immune response  immunity  tolerance  acute graft versus host disease  animal cell  animal experiment  animal model  Article  CD4+ T lymphocyte  cell death  cell expansion  cell fate  cell heterogeneity  cell loss  cell survival  controlled study  female  gene  gene deletion  homeostasis  immunological tolerance  in vivo study  long term survival  male  mouse  nonhuman  phenotype  priority journal  protein expression  protein function  rheumatoid arthritis  RNA sequencing  systemic lupus erythematosus  T lymphocyte  T lymphocyte activation  T lymphocyte subpopulation  TCR gene  upregulation  VISTA gene  animal  C57BL mouse  genetics  immunological tolerance  immunology  knockout mouse  lymphocyte activation  physiology  T lymphocyte  Mus  Animals  Antibodies, Monoclonal  B7 Antigens  Lymphocyte Activation  Membrane Proteins  Mice  Mice, Inbred C57BL  Mice, Knockout  Peripheral Tolerance  Receptors, Antigen, T-Cell  T-Lymphocytes  
Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Wang J.;  Li P.;  Yu Y.;  Fu Y.;  Jiang H.;  Lu M.;  Sun Z.;  Jiang S.;  Lu L.;  Wu M.X.
收藏  |  浏览/下载：45/0  |  提交时间：2020/07/28
2',3' cyclic guanosine monophosphate adenosine monophosphate  influenza vaccine  interferon  nanoparticle  pulmonary surfactant biomimetic nanoparticle  purine nucleotide  surfactant protein A  surfactant protein D  unclassified drug  cell  drug resistance  immune response  immunity  induced response  influenza  nanoparticle  rodent  surfactant  vaccine  animal cell  animal experiment  animal model  animal tissue  Article  CD8+ T lymphocyte  cellular immunity  controlled study  cross protection  cytokine response  drug efficacy  drug safety  drug synthesis  female  human  humoral immunity  hydrophilicity  immune response  immunopathology  immunosurveillance  influenza  innate immunity  lung alveolus epithelium cell  lung alveolus macrophage  mouse  Mustela putorius furo  nanoencapsulation  nonhuman  priority journal  Mus  Mustela  
Engineered symbionts activate honey bee immunity and limit pathogens 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:  Leonard S.P.;  Powell J.E.;  Perutka J.;  Geng P.;  Heckmann L.C.;  Horak R.D.;  Davies B.W.;  Ellington A.D.;  Barrick J.E.;  Moran N.A.
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/28
double stranded RNA  bacterium  engineering  honeybee  host-pathogen interaction  immune response  immunity  pathogen  symbiont  Article  bacterial colonization  controlled study  gene expression  gene repression  genetic engineering  honeybee  immunity  intestine flora  nonhuman  priority journal  RNA interference  Snodgrassella alvi  symbiont  Varroa  animal  bee  genetic engineering  genetics  immunology  microbiology  Neisseriaceae  physiology  symbiosis  Varroidae  Acari  Apis mellifera  Apoidea  Bacteria (microorganisms)  Eukaryota  Varroa  Animals  Bees  Gastrointestinal Microbiome  Genetic Engineering  Neisseriaceae  RNA Interference  Symbiosis  Varroidae  
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Gilan O.;  Rioja I.;  Knezevic K.;  Bell M.J.;  Yeung M.M.;  Harker N.R.;  Lam E.Y.N.;  Chung C.;  Bamborough P.;  Petretich M.;  Urh M.;  Atkinson S.J.;  Bassil A.K.;  Roberts E.J.;  Vassiliadis D.;  Burr M.L.;  Preston A.G.S.;  Wellaway C.;  Werner T.;  Gray J.R.;  Michon A.-M.;  Gobbetti T.;  Kumar V.;  Soden P.E.;  Haynes A.;  Vappiani J.;  Tough D.F.;  Taylor S.;  Dawson S.-J.;  Bantscheff M.;  Lindon M.;  Drewes G.;  Demont E.H.;  Daniels D.L.;  Grandi P.;  Prinjha R.K.;  Dawson M.A.
收藏  |  浏览/下载：44/0  |  提交时间：2020/07/28
7 (3,5 dimethyl 4 isoxazolyl) 1,3 dihydro 8 methoxy 1 [1 (2 pyridinyl)ethyl] 2h imidazo[4,5 c]quinolin 2 one  apremilast  bromodomain and extraterminal domain protein 1  bromodomain and extraterminal domain protein 2  bromodomain inhibitor  gsk 046  gsk 620  gsk 778  transcription factor  unclassified drug  cancer  drug  gene expression  immune response  inhibitor  physiological response  acute myeloid leukemia  animal experiment  animal model  animal tissue  antibody response  antineoplastic activity  antiproliferative activity  apoptosis  Article  binding affinity  controlled study  crystal structure  drug design  drug efficacy  drug protein binding  drug selectivity  drug specificity  drug structure  drug targeting  gene expression  high throughput screening  human  human cell  IC50  immunomodulation  in vivo study  inflammation  K-562 cell line  malignant neoplasm  MDA-MB-453 cell line  MOLM-13 cell line  mouse  nonhuman  priority journal  psoriasis  
A rampage through the body 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Wadman M.;  Couzin-Frankel J.;  Kaiser J.;  Matacic C.
收藏  |  浏览/下载：33/0  |  提交时间：2020/07/28
blood  brain  brain drain  cell organelle  immune response  infectious disease  protein  viral disease  Article  clinical feature  coronavirus disease 2019  disease severity  disease transmission  human  mortality rate  patient care  patient risk  priority journal  risk factor  Betacoronavirus  blood vessel  brain  Coronavirus infection  female  lung  male  middle aged  multiple organ failure  pandemic  pathogenicity  pathology  virology  virus entry  virus pneumonia  Betacoronavirus  Blood Vessels  Brain  Coronavirus Infections  Female  Humans  Lung  Male  Middle Aged  Multiple Organ Failure  Pandemics  Pneumonia, Viral  Virus Internalization  
Butyrophilin 2A1 is essential for phosphoantigen reactivity by gd T cells 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Rigau M.;  Ostrouska S.;  Fulford T.S.;  Johnson D.N.;  Woods K.;  Ruan Z.;  McWilliam H.E.G.;  Hudson C.;  Tutuka C.;  Wheatley A.K.;  Kent S.J.;  Villadangos J.A.;  Pal B.;  Kurts C.;  Simmonds J.;  Pelzing M.;  Nash A.D.;  Hammet A.;  Verhagen A.M.;  Vairo G.;  Maraskovsky E.;  Panousis C.;  Gherardin N.A.;  Cebon J.;  Godfrey D.I.;  Behren A.;  Uldrich A.P.
收藏  |  浏览/下载：45/0  |  提交时间：2020/07/28
antigen  butyrophilin  butyrophilin 2A1  butyrophilin 3A1  phosphoantigen  unclassified drug  antigen  cancer  cell  immune response  protein  antigen antibody reaction  antigen recognition  Article  controlled study  gamma delta T lymphocyte  human  human cell  immunocompetent cell  immunotherapy  lymphocyte activation  priority journal  protein analysis  protein binding  protein domain  protein interaction  
Effects of hydroperiod on growth, development, survival and immune defences in a temperate amphibian 期刊论文
FUNCTIONAL ECOLOGY, 2019
作者:  Brannelly, Laura A.;  Ohmer, Michel E. B.;  Saenz, Veronica;  Richards-Zawacki, Corinne L.
收藏  |  浏览/下载：32/0  |  提交时间：2019/10/08
climate change  ecoimmunology  environmental change  hydroperiod  immune response  larval period  pond drying  Rana pipiens  
Heightened Immune System Function in Polar Bears Using Terrestrial Habitats 期刊论文
PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY, 2019, 卷号: 92, 期号: 1, 页码: 1-11
作者:  Whiteman, John P.;  Harlow, Henry J.;  Durner, George M.;  Regehr, Eric V.;  Amstrup, Steven C.;  Ben-David, Merav
收藏  |  浏览/下载：18/0  |  提交时间：2019/10/08
adaptive immune response  energy balance  hematology  innate immune response