气候变化领域集成服务门户(CCPortal): Structure of the secretory immunoglobulin A core

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DOI	10.1126/science.aaz5807
	Structure of the secretory immunoglobulin A core
	Kumar N.; Arthur C.P.; Ciferri C.; Matsumoto M.L.
发表日期	2020
ISSN	0036-8075
起始页码	1008
结束页码	1014
卷号	367 期号:6481
英文摘要	Secretory immunoglobulin A (sIgA) represents the immune system's first line of defense against mucosal pathogens. IgAs are transported across the epithelium, as dimers and higher-order polymers, by the polymeric immunoglobulin receptor (pIgR). Upon reaching the luminal side, sIgAs mediate host protection and pathogen neutralization. In recent years, an increasing amount of attention has been given to IgA as a novel therapeutic antibody. However, despite extensive studies, sIgA structures have remained elusive. Here, we determine the atomic resolution structures of dimeric, tetrameric, and pentameric IgA-Fc linked by the joining chain (JC) and in complex with the secretory component of the pIgR. We suggest a mechanism in which the JC templates IgA oligomerization and imparts asymmetry for pIgR binding and transcytosis. This framework will inform the design of future IgA-based therapeutics. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
关键词	dimer immunoglobulin receptor oligomer pentamer secretory component secretory immunoglobulin tetramer unclassified drug antibody immune response immunity pathogen physiological response protein secretion antigen antibody complex antigen binding Article cryoelectron microscopy human immune reconstitution immunity immunoglobulin structure oligomerization priority journal transcytosis
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133678
推荐引用方式 GB/T 7714	Kumar N.,Arthur C.P.,Ciferri C.,et al. Structure of the secretory immunoglobulin A core[J]. Science,2020,367(6481).
APA	Kumar N.,Arthur C.P.,Ciferri C.,&Matsumoto M.L..(2020).Structure of the secretory immunoglobulin A core.,367(6481).
MLA	Kumar N.,et al."Structure of the secretory immunoglobulin A core".367.6481(2020).