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DOI10.1126/science.aay5516
Butyrophilin 2A1 is essential for phosphoantigen reactivity by gd T cells
Rigau M.; Ostrouska S.; Fulford T.S.; Johnson D.N.; Woods K.; Ruan Z.; McWilliam H.E.G.; Hudson C.; Tutuka C.; Wheatley A.K.; Kent S.J.; Villadangos J.A.; Pal B.; Kurts C.; Simmonds J.; Pelzing M.; Nash A.D.; Hammet A.; Verhagen A.M.; Vairo G.; Maraskovsky E.; Panousis C.; Gherardin N.A.; Cebon J.; Godfrey D.I.; Behren A.; Uldrich A.P.
发表日期2020
ISSN0036-8075
卷号367期号:6478
英文摘要Gamma delta (gd) T cells are essential to protective immunity. In humans, most gd T cells express Vg9Vd2+ T cell receptors (TCRs) that respond to phosphoantigens (pAgs) produced by cellular pathogens and overexpressed by cancers. However, the molecular targets recognized by these gdTCRs are unknown. Here, we identify butyrophilin 2A1 (BTN2A1) as a key ligand that binds to the Vg9+ TCR g chain. BTN2A1 associates with another butyrophilin, BTN3A1, and these act together to initiate responses to pAg. Furthermore, binding of a second ligand, possibly BTN3A1, to a separate TCR domain incorporating Vd2 is also required. This distinctive mode of Ag-dependent T cell activation advances our understanding of diseases involving pAg recognition and creates opportunities for the development of gd T cell–based immunotherapies. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词antigenbutyrophilinbutyrophilin 2A1butyrophilin 3A1phosphoantigenunclassified drugantigencancercellimmune responseproteinantigen antibody reactionantigen recognitionArticlecontrolled studygamma delta T lymphocytehumanhuman cellimmunocompetent cellimmunotherapylymphocyte activationpriority journalprotein analysisprotein bindingprotein domainprotein interaction
语种英语
来源机构Science
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/133731
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Rigau M.,Ostrouska S.,Fulford T.S.,et al. Butyrophilin 2A1 is essential for phosphoantigen reactivity by gd T cells[J]. Science,2020,367(6478).
APA Rigau M..,Ostrouska S..,Fulford T.S..,Johnson D.N..,Woods K..,...&Uldrich A.P..(2020).Butyrophilin 2A1 is essential for phosphoantigen reactivity by gd T cells.,367(6478).
MLA Rigau M.,et al."Butyrophilin 2A1 is essential for phosphoantigen reactivity by gd T cells".367.6478(2020).
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