气候变化领域集成服务门户(CCPortal): Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity

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DOI	10.1126/science.aau0810
	Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity
	Wang J.; Li P.; Yu Y.; Fu Y.; Jiang H.; Lu M.; Sun Z.; Jiang S.; Lu L.; Wu M.X.
发表日期	2020
ISSN	0036-8075
卷号	367 期号:6480
英文摘要	Current influenza vaccines only confer protection against homologous viruses. We synthesized pulmonary surfactant (PS)-biomimetic liposomes encapsulating 2',3'-cyclic guanosine monophosphate- adenosine monophosphate (cGAMP), an agonist of the interferon gene inducer STING (stimulator of interferon genes). The adjuvant (PS-GAMP) vigorously augmented influenza vaccine-induced humoral and CD8+ T cell immune responses in mice by simulating the early phase of viral infection without concomitant excess inflammation. Two days after intranasal immunization with PS-GAMP-adjuvanted H1N1 vaccine, strong cross-protection was elicited against distant H1N1 and heterosubtypic H3N2, H5N1, and H7N9 viruses for at least 6 months while maintaining lung-resident memory CD8+ T cells. Adjuvanticity was then validated in ferrets. When alveolar epithelial cells (AECs) lacked Sting or gap junctions were blocked, PS-GAMP-mediated adjuvanticity was substantially abrogated in vivo. Thus, AECs play a pivotal role in configuring heterosubtypic immunity. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	2',3' cyclic guanosine monophosphate adenosine monophosphate influenza vaccine interferon nanoparticle pulmonary surfactant biomimetic nanoparticle purine nucleotide surfactant protein A surfactant protein D unclassified drug cell drug resistance immune response immunity induced response influenza nanoparticle rodent surfactant vaccine animal cell animal experiment animal model animal tissue Article CD8+ T lymphocyte cellular immunity controlled study cross protection cytokine response drug efficacy drug safety drug synthesis female human humoral immunity hydrophilicity immune response immunopathology immunosurveillance influenza innate immunity lung alveolus epithelium cell lung alveolus macrophage mouse Mustela putorius furo nanoencapsulation nonhuman priority journal Mus Mustela
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133693
推荐引用方式 GB/T 7714	Wang J.,Li P.,Yu Y.,et al. Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity[J]. Science,2020,367(6480).
APA	Wang J..,Li P..,Yu Y..,Fu Y..,Jiang H..,...&Wu M.X..(2020).Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity.,367(6480).
MLA	Wang J.,et al."Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity".367.6480(2020).