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ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 17
作者:  Mena E.L.;  Donahue C.J.;  Vaites L.P.;  Li J.;  Rona G.;  O'Leary C.;  Lignitto L.;  Miwatani-Minter B.;  Paulo J.A.;  Dhabaria A.;  Ueberheide B.;  Gygi S.P.;  Pagano M.;  Harper J.W.;  Davey R.A.;  Elledge S.J.
收藏  |  浏览/下载:25/0  |  提交时间:2021/05/24
Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis 期刊论文
Nature Communications, 2021, 卷号: 12, 期号: 1
作者:  Friedrich T.;  Oberkofler V.;  Trindade I.;  Altmann S.;  Brzezinka K.;  Lämke J.;  Gorka M.;  Kappel C.;  Sokolowska E.;  Skirycz A.;  Graf A.;  Bäurle I.
收藏  |  浏览/下载:37/0  |  提交时间:2022/02/22
Expression attenuation as a mechanism of robustness against gene duplication 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 6
作者:  Ascencio D.;  Diss G.;  Gagnon-Arsenault I.;  Dubé A.K.;  DeLuna A.;  Landry C.R.
收藏  |  浏览/下载:32/0  |  提交时间:2021/05/24
EIN3 and RSL4 interfere with an MYB–bHLH–WD40 complex to mediate ethylene-induced ectopic root hair formation in Arabidopsis 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 51
作者:  Qiu Y.;  Tao R.;  Feng Y.;  Xiao Z.;  Zhang D.;  Peng Y.;  Wen X.;  Wang Y.;  Guo H.
收藏  |  浏览/下载:38/0  |  提交时间:2022/02/22
High-throughput suppressor screen demonstrates that RcsF monitors outer membrane integrity and not Bam complex function 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 32
作者:  Tata M.;  Kumar S.;  Lach S.R.;  Saha S.;  Hart E.M.;  Konovalova A.
收藏  |  浏览/下载:46/0  |  提交时间:2022/02/22
RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 36
作者:  Pérez-Schindler J.;  Kohl B.;  Schneider-Heieck K.;  Leuchtmann A.B.;  Henríquez-Olguín C.;  Adak V.;  Maier G.;  Delezie J.;  Sakoparnig T.;  Vargas-Fernández E.;  Karrer-Cardel B.;  Ritz D.;  Schmidt A.;  Hondele M.;  Jensen T.E.;  Hiller S.;  Handschin C.
收藏  |  浏览/下载:29/0  |  提交时间:2022/02/22
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir 期刊论文
, 2020, 卷号: 368, 期号: 6498
作者:  Yin W.;  Mao C.;  Luan X.;  Shen D.-D.;  Shen Q.;  Su H.;  Wang X.;  Zhou F.;  Zhao W.;  Gao M.;  Chang S.;  Xie Y.-C.;  Tian G.;  Jiang H.-W.;  Tao S.-C.;  Shen J.;  Jiang Y.;  Jiang H.;  Xu Y.;  Zhang S.;  Zhang Y.;  Xu H.E.
收藏  |  浏览/下载:189/0  |  提交时间:2020/07/28
adenosine phosphate  alanine  antivirus agent  enzyme inhibitor  multiprotein complex  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  virus RNA  Betacoronavirus  chemistry  cryoelectron microscopy  drug effect  enzyme active site  enzymology  metabolism  molecular model  physiology  protein conformation  virus replication  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Enzyme Inhibitors  Models, Molecular  Multiprotein Complexes  Protein Conformation  RNA Replicase  RNA, Viral  Viral Nonstructural Proteins  Virus Replication  
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Pareek V.;  Tian H.;  Winograd N.;  Benkovic S.J.
收藏  |  浏览/下载:32/0  |  提交时间:2020/07/28
adenosine phosphate  guanosine phosphate  multienzyme complex  nucleotide  purine  purine  purine derivative  cell  experimental study  imaging method  mass spectrometry  metabolism  protein  Article  biochemistry  enzyme assay  gas cluster ion beam secondary ion mass spectrometry  image analysis  mass spectrometry  metabolomics  mitochondrion  molecular imaging  molecular probe  priority journal  purine synthesis  reaction analysis  single cell analysis  biosynthesis  fluorescence imaging  HeLa cell line  human  metabolism  metabolomics  procedures  secondary ion mass spectrometry  HeLa Cells  Humans  Metabolomics  Mitochondria  Multienzyme Complexes  Optical Imaging  Purines  Single-Cell Analysis  Spectrometry, Mass, Secondary Ion  
Structural basis for strand-transfer inhibitor binding to HIV intasomes 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Passos D.O.;  Li M.;  Jóźwik I.K.;  Zhao X.Z.;  Santos-Martins D.;  Yang R.;  Smith S.J.;  Jeon Y.;  Forli S.;  Hughes S.H.;  Burke T.R.;  Jr.;  Craigie R.;  Lyumkis D.
收藏  |  浏览/下载:26/0  |  提交时间:2020/07/28
bictegravir  nucleoprotein  protein intasome  unclassified drug  viral protein  bictegravir  fused heterocyclic rings  integrase  integrase inhibitor  multiprotein complex  naphthyridine derivative  nucleoprotein  biochemistry  chemical binding  human immunodeficiency virus  inhibitor  protein  ultrastructure  amino terminal sequence  Article  carboxy terminal sequence  catalysis  cryoelectron microscopy  drug design  drug efficacy  drug protein binding  drug resistance  drug structure  enzyme active site  human  Human immunodeficiency virus infection  nonhuman  priority journal  protein purification  protein structure  antiviral resistance  chemistry  drug effect  genetics  Human immunodeficiency virus  virus DNA cell DNA interaction  Cryoelectron Microscopy  Drug Design  Drug Resistance, Viral  Heterocyclic Compounds, 4 or More Rings  HIV  HIV Integrase  HIV Integrase Inhibitors  Humans  Multiprotein Complexes  Naphthyridines  Nucleoproteins  Virus Integration  
Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells 期刊论文
, 2020, 卷号: 368, 期号: 6493
作者:  Bálint Š.;  Müller S.;  Fischer R.;  Kessler B.M.;  Harkiolaki M.;  Valitutti S.;  Dustin M.L.
收藏  |  浏览/下载:45/0  |  提交时间:2020/07/28
cancer  cell  identification method  molecular analysis  reconstruction  granzyme  multiprotein complex  perforin  thrombospondin 1  CRISPR Cas system  cytotoxic T lymphocyte  cytotoxicity  exocytosis  gene editing  genetics  human  K-562 cell line  metabolism  x-ray tomography  CRISPR-Cas Systems  Cytotoxicity, Immunologic  Exocytosis  Gene Editing  Granzymes  Humans  K562 Cells  Multiprotein Complexes  Perforin  T-Lymphocytes, Cytotoxic  Thrombospondin 1  Tomography, X-Ray