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| Structure of the secretory immunoglobulin A core 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者: Kumar N.; Arthur C.P.; Ciferri C.; Matsumoto M.L.
  收藏 | 浏览/下载：31/0 | 提交时间：2020/07/28
dimer immunoglobulin receptor oligomer pentamer secretory component secretory immunoglobulin tetramer unclassified drug antibody immune response immunity pathogen physiological response protein secretion antigen antibody complex antigen binding Article cryoelectron microscopy human immune reconstitution immunity immunoglobulin structure oligomerization priority journal transcytosis |
| Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: He S.; Wu Z.; Tian Y.; Yu Z.; Yu J.; Wang X.; Li J.; Liu B.; Xu Y.
收藏 | 浏览/下载：32/0 | 提交时间：2020/07/28
actin related protein adenosine triphosphatase BRG1 BRM associated factor DNA multiprotein complex protein SWI retinoblastoma binding protein 2 SMARCC protein SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1 transcription factor transcription factor SNF unclassified drug cancer enzyme activity gene expression hydrolysis mutation protein alpha helix Article carboxy terminal sequence cell interaction cryoelectron microscopy disease association human malignant neoplasm molecular recognition mutation nucleosome priority journal protein function protein hydrolysis protein structure structure analysis Mammalia |
| Ancient origins of allosteric activation in a Ser-Thr kinase 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Hadzipasic A.; Wilson C.; Nguyen V.; Kern N.; Kim C.; Pitsawong W.; Villali J.; Zheng Y.; Kern D.
收藏 | 浏览/下载：43/0 | 提交时间：2020/07/28
aurora A kinase microtubule associated protein TPX2 protein unclassified drug activation energy ancestry cell chemical binding experimental study fitness protein allosterism amino acid sequence Article binding affinity binding site enzyme activation enzyme activity enzyme binding enzyme localization enzyme phosphorylation gene duplication horizontal gene transfer human hydrophobicity intracellular signaling phylogenetic tree phylogeny priority journal protein binding protein localization protein protein interaction |
| TTC5 mediates autoregulation of tubulin via mRNA degradation 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者: Lin Z.; Gasic I.; Chandrasekaran V.; Peters N.; Shao S.; Mitchison T.J.; Hegde R.S.
收藏 | 浏览/下载：22/0 | 提交时间：2020/07/28
messenger RNA mutant protein polypeptide recombinant protein regulator protein tetratricopeptide protein 5 tubulin unclassified drug biodegradation chromosome peptide protein RNA amino terminal sequence animal cell Article autoregulation binding site chromosome segregation controlled study cryoelectron microscopy genetic code human human cell Leporidae mitosis molecular model nonhuman priority journal protein analysis protein binding protein interaction protein structure reticulocyte ribosome RNA degradation RNA translation tubulin gene |
| Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Zhang L.; Zhao Y.; Gao Y.; Wu L.; Gao R.; Zhang Q.; Wang Y.; Wu C.; Wu F.; Gurcha S.S.; Veerapen N.; Batt S.M.; Zhao W.; Qin L.; Yang X.; Wang M.; Zhu Y.; Zhang B.; Bi L.; Zhang X.; Yang H.; Guddat L.W.; Xu W.; Wang Q.; Li J.; Besra G.S.; Rao Z.
收藏 | 浏览/下载：32/0 | 提交时间：2020/07/28
biochemistry cell component chemical binding detection method drug drug resistance enzyme enzyme activity inhibition mutation Mycobacterium tuberculosis arabinosyltransferase ethambutol glycosyltransferase tuberculostatic agent cell wall chemistry cryoelectron microscopy enzymology multidrug resistance Mycobacterium tuberculosis protein conformation Antitubercular Agents Cell Wall Cryoelectron Microscopy Drug Resistance, Multiple, Bacterial Ethambutol Mycobacterium tuberculosis Pentosyltransferases Protein Conformation |
| Regenerative potential of prostate luminal cells revealed by single-cell analysis 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者: Karthaus W.R.; Hofree M.; Choi D.; Linton E.L.; Turkekul M.; Bejnood A.; Carver B.; Gopalan A.; Abida W.; Laudone V.; Biton M.; Chaudhary O.; Xu T.; Masilionis I.; Manova K.; Mazutis L.; Pe’er D.; Regev A.; Sawyers C.L.
收藏 | 浏览/下载：129/0 | 提交时间：2020/07/28
androgen growth factor Nrg2 growth factor Rspo3 growth factor unclassified drug androgen binding protein antiandrogen ataxin 1 Atxn1 protein, mouse glycosylphosphatidylinositol anchored protein homeodomain protein nerve growth factor Nkx3-1 protein, mouse Nrg2 protein, mouse probasin Psca protein, mouse R-spondin3 protein, mouse thrombospondin transcription factor tumor antigen tumor protein androgen cancer cell gene expression RNA rodent ablation therapy animal cell animal tissue Article cell differentiation cell population cell regeneration cells by body anatomy controlled study gene gene expression human luminal cell male mesenchyme cell mouse nonhuman paracrine signaling priority journal prostate cell prostate tissue protein expression Psca gene RNA sequencing Sca1 gene single cell analysis animal genetics mesenchymal stem cell metabolism organ size organoid physiology prostate prostate tumor regeneration sequence analysis single cell analysis Mus Androgen Antagonists Androgen-Binding Protein Androgens Animals Antigens, Neoplasm Ataxin-1 Cell Differentiation Gene Expression GPI-Linked Proteins Homeodomain Proteins Humans Male Mesenchymal Stem Cells Mice Neoplasm Proteins Nerve Growth Factors Organ Size Organoids Prostate Prostatic Neoplasms Regeneration Sequence Analysis, RNA Single-Cell Analysis Thrombospondins Transcription Factors |
| Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者: Britton C.S.; Sorrells T.R.; Johnson A.D.
收藏 | 浏览/下载：12/0 | 提交时间：2020/07/28
DNA binding protein fungal protein homeodomain protein Matalpha2 protein regulator protein transcription factor unclassified drug gene gene expression protein amino acid sequence Article cladistics controlled study gene deletion gene expression regulation gene repression gene sequence gene structure molecular evolution nonhuman priority journal protein DNA binding protein function protein structure Saccharomycotina sequence homology species transcription regulation Wickerhamomyces anomalus Fungi |
| Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者: Gilan O.; Rioja I.; Knezevic K.; Bell M.J.; Yeung M.M.; Harker N.R.; Lam E.Y.N.; Chung C.; Bamborough P.; Petretich M.; Urh M.; Atkinson S.J.; Bassil A.K.; Roberts E.J.; Vassiliadis D.; Burr M.L.; Preston A.G.S.; Wellaway C.; Werner T.; Gray J.R.; Michon A.-M.; Gobbetti T.; Kumar V.; Soden P.E.; Haynes A.; Vappiani J.; Tough D.F.; Taylor S.; Dawson S.-J.; Bantscheff M.; Lindon M.; Drewes G.; Demont E.H.; Daniels D.L.; Grandi P.; Prinjha R.K.; Dawson M.A.
收藏 | 浏览/下载：26/0 | 提交时间：2020/07/28
7 (3,5 dimethyl 4 isoxazolyl) 1,3 dihydro 8 methoxy 1 [1 (2 pyridinyl)ethyl] 2h imidazo[4,5 c]quinolin 2 one apremilast bromodomain and extraterminal domain protein 1 bromodomain and extraterminal domain protein 2 bromodomain inhibitor gsk 046 gsk 620 gsk 778 transcription factor unclassified drug cancer drug gene expression immune response inhibitor physiological response acute myeloid leukemia animal experiment animal model animal tissue antibody response antineoplastic activity antiproliferative activity apoptosis Article binding affinity controlled study crystal structure drug design drug efficacy drug protein binding drug selectivity drug specificity drug structure drug targeting gene expression high throughput screening human human cell IC50 immunomodulation in vivo study inflammation K-562 cell line malignant neoplasm MDA-MB-453 cell line MOLM-13 cell line mouse nonhuman priority journal psoriasis |
| Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a-ketoamide inhibitors 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者: Zhang L.; Lin D.; Sun X.; Curth U.; Drosten C.; Sauerhering L.; Becker S.; Rox K.; Hilgenfeld R.
收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
alanine alpha ketoamide inhibitor antivirus agent isoleucine leucine proteinase Severe acute respiratory syndrome coronavirus 2 main protease threonine unclassified drug crystal structure drug enzyme enzyme activity inhibitor reaction kinetics amino acid sequence animal cell animal experiment animal tissue antiviral activity Article catalysis catalytic efficiency controlled study crystal structure dimerization dissociation constant drug clearance drug design drug distribution drug half life drug potency drug protein binding drug solubility drug structure EC50 enzyme inhibition human human cell hydrogen bond hydrophobicity IC50 maximum concentration mean residence time metabolic stability mouse nonhuman priority journal protein structure RNA replication SARS coronavirus Severe acute respiratory syndrome coronavirus 2 viral tropism virus inhibition Coronavirus SARS coronavirus |
| Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者: Rougé L.; Chiang N.; Steffek M.; Kugel C.; Croll T.I.; Tam C.; Estevez A.; Arthur C.P.; Koth C.M.; Ciferri C.; Kraft E.; Payandeh J.; Nakamura G.; Koerber J.T.; Rohou A.
收藏 | 浏览/下载：19/0 | 提交时间：2020/07/28
CD20 antigen dimer epitope Fc receptor immunoglobulin F(ab) fragment obinutuzumab ocrelizumab ofatumumab rituximab tositumomab i 131 antibody antigen cell chemical binding composite gene expression genetic marker protein amino acid sequence antibody dependent cellular cytotoxicity antigen antibody complex antigen binding antigen structure Article cell death cell surface chemical bond complement dependent cytotoxicity drug protein binding drug targeting electron microscopy human humoral immune deficiency insect cell lipid raft malignant neoplasm molecular recognition multiple sclerosis nonhuman phagocytosis priority journal protein cross linking protein interaction stoichiometry surface plasmon resonance |
