气候变化领域集成服务门户(CCPortal): Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit

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DOI	10.1126/science.aax5217
	Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit
	Britton C.S.; Sorrells T.R.; Johnson A.D.
发表日期	2020
ISSN	0036-8075
起始页码	96
结束页码	100
卷号	367 期号:6473
英文摘要	Changes in both the coding sequence of transcriptional regulators and in the cis-regulatory sequences recognized by these regulators have been implicated in the evolution of transcriptional circuits. However, little is known about how they evolved in concert. We describe an evolutionary pathway in fungi where a new transcriptional circuit (a-specific gene repression by the homeodomain protein Mata2) evolved by coding changes in this ancient regulator, followed millions of years later by cis-regulatory sequence changes in the genes of its future regulon. By analyzing a group of species that has acquired the coding changes but not the cis-regulatory sites, we show that the coding changes became necessary for the regulator's deeply conserved function, thereby poising the regulator to jump-start formation of the new circuit. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	DNA binding protein fungal protein homeodomain protein Matalpha2 protein regulator protein transcription factor unclassified drug gene gene expression protein amino acid sequence Article cladistics controlled study gene deletion gene expression regulation gene repression gene sequence gene structure molecular evolution nonhuman priority journal protein DNA binding protein function protein structure Saccharomycotina sequence homology species transcription regulation Wickerhamomyces anomalus Fungi
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133816
推荐引用方式 GB/T 7714	Britton C.S.,Sorrells T.R.,Johnson A.D.. Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit[J]. Science,2020,367(6473).
APA	Britton C.S.,Sorrells T.R.,&Johnson A.D..(2020).Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit.,367(6473).
MLA	Britton C.S.,et al."Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit".367.6473(2020).