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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Wilmes S.;  Hafer M.;  Vuorio J.;  Tucker J.A.;  Winkelmann H.;  Löchte S.;  Stanly T.A.;  Pulgar Prieto K.D.;  Poojari C.;  Sharma V.;  Richter C.P.;  Kurre R.;  Hubbard S.R.;  Christopher Garcia K.;  Moraga I.;  Vattulainen I.;  Hitchcock I.S.;  Piehler J.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/28
cytokine receptor  homodimer  Janus kinase 2  ligand  oncoprotein  cancer  enzyme  enzyme activity  membrane  molecular analysis  mutation  protein  activation analysis  Article  cell membrane  computer model  controlled study  dimerization  fluorescence microscopy  gene mutation  HeLa cell line  molecular dynamics  mutant  oncogene  priority journal  protein domain  protein interaction  quantitative analysis  signal transduction  
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Guthrie L.M.;  Soma S.;  Yuan S.;  Silva A.;  Zulkifli M.;  Snavely T.C.;  Greene H.F.;  Nunez E.;  Lynch B.;  de Ville C.;  Shanbhag V.;  Lopez F.R.;  Acharya A.;  Petris M.J.;  Kim B.-E.;  Gohil V.M.;  Sacchettini J.C.
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/28
copper  copper zinc superoxide dismutase  cytochrome c oxidase  dopamine beta monooxygenase  elesclomol  monophenol monooxygenase  protein lysine 6 oxidase  copper  cytochrome c oxidase  elesclomol  hydrazine derivative  copper  cytochrome  enzyme  enzyme activity  mitochondrion  mortality  mutation  pathology  rodent  survival  animal cell  animal experiment  animal model  animal tissue  Article  cohort analysis  controlled study  disease severity  drug mechanism  Golgi complex  H9c2(2-1) cell line  in vivo study  male  Menkes syndrome  mitochondrial dynamics  mortality rate  mouse  nerve degeneration  nonhuman  priority journal  secretory pathway  survival rate  animal  brain  cell line  degenerative disease  disease model  drug effect  genetics  knockout mouse  Menkes syndrome  metabolism  mitochondrion  pathology  rat  transport at the cellular level  Murinae  Mus  Animals  Biological Transport  Brain  Cell Line  Copper  Copper Transporter 1  Disease Models, Animal  Electron Transport Complex IV  Hydrazines  Male  Menkes Kinky Hair Syndrome  Mice  Mice, Knockout  Mitochondria  Neurodegenerative Diseases  Rats  
Effective containment explains subexponential growth in recent confirmed COVID-19 cases in China 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Maier B.F.;  Brockmann D.
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/28
disease control  disease prevalence  epidemic  health geography  public health  quarantine  symptom  viral disease  China  Coronavirus  basic reproduction number  behavior  Betacoronavirus  China  communicable disease control  contact examination  Coronavirus infection  disease predisposition  epidemic  human  pandemic  quarantine  statistical model  virus pneumonia  Basic Reproduction Number  Behavior  Betacoronavirus  China  Communicable Disease Control  Contact Tracing  Coronavirus Infections  Disease Outbreaks  Disease Susceptibility  Humans  Models, Statistical  Pandemics  Pneumonia, Viral  Quarantine  
A neurodevelopmental origin of behavioral individuality in the Drosophila visual system 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Linneweber G.A.;  Andriatsilavo M.;  Dutta S.B.;  Bengochea M.;  Hellbruegge L.;  Liu G.;  Ejsmont R.K.;  Straw A.D.;  Wernet M.;  Hiesinger P.R.;  Hassan B.A.
收藏  |  浏览/下载：31/0  |  提交时间：2020/07/28
anatomy  asymmetry  brain  genome  neurology  orientation  visual analysis  article  brain  Drosophila melanogaster  human experiment  individuality  nerve cell  nonhuman  stochastic model  visual system  walking  anatomy and histology  animal  Drosophila melanogaster  genetic variation  genetics  growth, development and aging  nervous system development  orientation  physiology  visual field  visual system  Drosophila melanogaster  Animals  Brain  Drosophila melanogaster  Genetic Variation  Individuality  Neurogenesis  Orientation  Visual Fields  Visual Pathways  
On impact and volcanism across the Cretaceous-Paleogene boundary 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  Hull P.M.;  Bornemann A.;  Penman D.E.;  Henehan M.J.;  Norris R.D.;  Wilson P.A.;  Blum P.;  Alegret L.;  Batenburg S.J.;  Bown P.R.;  Bralower T.J.;  Cournede C.;  Deutsch A.;  Donner B.;  Friedrich O.;  Jehle S.;  Kim H.;  Kroon D.;  Lippert P.C.;  Loroch D.;  Moebius I.;  Moriya K.;  Peppe D.J.;  Ravizza G.E.;  Röhl U.;  Schueth J.D.;  Sepúlveda J.;  Sexton P.F.;  Sibert E.C.;  Śliwińska K.K.;  Summons R.E.;  Thomas E.;  Westerhold T.;  Whiteside J.H.;  Yamaguchi T.;  Zachos J.C.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
carbon dioxide  carbon dioxide  carbon cycle  carbon dioxide  Cretaceous-Paleogene boundary  flood basalt  global warming  mass extinction  paleotemperature  volcanism  Article  astronomy  basalt  bolide  boundary layer  carbon cycle  confusion (uncertainty)  cosmological phenomena  end Cretaceous mass extinction  environmental impact  environmental temperature  greenhouse effect  paleoenvironment  Paleogene  priority journal  sea  volcanic outgassing  volcanism  carbon cycle  Mexico  species extinction  theoretical model  volcano  Carbon Cycle  Carbon Dioxide  Extinction, Biological  Global Warming  Mexico  Models, Theoretical  Volcanic Eruptions  
The hunger: Forecast 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Voosen P.
收藏  |  浏览/下载：106/0  |  提交时间：2020/07/28
hot water  rain  forecasting method  gene expression  literature review  psychology  Africa  agricultural land  agricultural management  agronomy  air temperature  Article  climate change  coastal waters  consumer  Coronavirus infection  crop production  economic aspect  economic development  El Nino  environmental monitoring  environmental temperature  Europe  evaporation  financial management  flooding  food assistance  food handling  food security  government  greenhouse effect  human  hunger  Indian Ocean  low income country  Madagascar  maize  pandemic  prediction  priority journal  public figure  risk factor  satellite imagery  scientist  seasonal variation  soil moisture  storm (weather)  United States  warming  drought  forecasting  hunger  theoretical model  Africa, Eastern  Droughts  Famine  Forecasting  Models, Theoretical  
Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:  Uckelmann H.J.;  Kim S.M.;  Wong E.M.;  Hatton C.;  Giovinazzo H.;  Gadrey J.Y.;  Krivtsov A.V.;  Rücker F.G.;  Döhner K.;  McGeehan G.M.;  Levine R.L.;  Bullinger L.;  Vassiliou G.S.;  Armstrong S.A.
收藏  |  浏览/下载：24/0  |  提交时间：2020/07/28
antileukemic agent  methionine  unclassified drug  vtp 50469  biological development  cancer  cell  disease treatment  mutation  numerical model  oral health  acute myeloid leukemia  animal cell  animal experiment  animal model  antineoplastic activity  Article  cell proliferation  cell self-renewal  chromatin  controlled study  drug targeting  gene  gene mutation  leukemia cell  molecularly targeted therapy  mouse  mouse model  nonhuman  NPM1 gene  preleukemia  priority journal  Mus  
Single-cell transcriptional diversity is a hallmark of developmental potential 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者:  Gulati G.S.;  Sikandar S.S.;  Wesche D.J.;  Manjunath A.;  Bharadwaj A.;  Berger M.J.;  Ilagan F.;  Kuo A.H.;  Hsieh R.W.;  Cai S.;  Zabala M.;  Scheeren F.A.;  Lobo N.A.;  Qian D.;  Yu F.B.;  Dirbas F.M.;  Clarke M.F.;  Newman A.M.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
cell  cell component  developmental biology  experimental study  genetic analysis  tumor  Article  breast cancer  breast carcinogenesis  carcinogenesis  cell differentiation  computer model  embryonic stem cell  gene expression  genetic code  genetic variability  human  in vivo study  nonhuman  phenotype  priority journal  scoring system  single cell RNA seq  upregulation  
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Yuan M.;  Wu N.C.;  Zhu X.;  Lee C.-C.D.;  So R.T.Y.;  Lv H.;  Mok C.K.P.;  Wilson I.A.
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  epitope  neutralizing antibody  virus hemagglutinin  virus spike protein  angiotensin converting enzyme 2  coronavirus receptors  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  neutralizing antibody  spike glycoprotein, SARS-CoV  spike protein, SARS-CoV-2  virus antibody  virus antigen  virus receptor  antibody  antigen  chemical binding  crystal structure  protein  respiratory disease  viral disease  virus  amino terminal sequence  antibody isolation  antigen binding  antigenicity  Article  binding affinity  binding site  conservation biology  controlled study  coronavirus disease 2019  cross reaction  cryoelectron microscopy  crystal structure  enzyme linked immunosorbent assay  epidemic  glycosylation  human  hydrophobicity  immune response  in vitro study  in vivo study  light chain  nonhuman  priority journal  protein conformation  protein domain  protein interaction  protein localization  protein structure  protein targeting  receptor binding  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  antibody affinity  Betacoronavirus  binding site  chemistry  immunology  metabolism  molecular model  SARS coronavirus  X ray crystallography  Coronavirus  SARS coronavirus  Amino Acid Sequence  Antibodies, Neutralizing  Antibodies, Viral  Antibody Affinity  Antigens, Viral  Betacoronavirus  Binding Sites  Cross Reactions  Crystallography, X-Ray  Epitopes  Models, Molecular  Peptidyl-Dipeptidase A  Protein Conformation  Protein Domains  Protein Interaction Domains and Motifs  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus