气候变化领域集成服务门户(CCPortal): A neurodevelopmental origin of behavioral individuality in the Drosophila visual system

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DOI	10.1126/science.aaz4547
	A neurodevelopmental origin of behavioral individuality in the Drosophila visual system
	Linneweber G.A.; Andriatsilavo M.; Dutta S.B.; Bengochea M.; Hellbruegge L.; Liu G.; Ejsmont R.K.; Straw A.D.; Wernet M.; Hiesinger P.R.; Hassan B.A.
发表日期	2020
ISSN	0036-8075
起始页码	1112
结束页码	1119
卷号	367 期号:6482
英文摘要	The genome versus experience dichotomy has dominated understanding of behavioral individuality. By contrast, the role of nonheritable noise during brain development in behavioral variation is understudied. Using Drosophila melanogaster, we demonstrate a link between stochastic variation in brain wiring and behavioral individuality. A visual system circuit called the dorsal cluster neurons (DCN) shows nonheritable, interindividual variation in right/left wiring asymmetry and controls object orientation in freely walking flies. We show that DCN wiring asymmetry instructs an individual's object responses: The greater the asymmetry, the better the individual orients toward a visual object. Silencing DCNs abolishes correlations between anatomy and behavior, whereas inducing DCN asymmetry suffices to improve object responses. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	anatomy asymmetry brain genome neurology orientation visual analysis article brain Drosophila melanogaster human experiment individuality nerve cell nonhuman stochastic model visual system walking anatomy and histology animal Drosophila melanogaster genetic variation genetics growth, development and aging nervous system development orientation physiology visual field visual system Drosophila melanogaster Animals Brain Drosophila melanogaster Genetic Variation Individuality Neurogenesis Orientation Visual Fields Visual Pathways
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133655
推荐引用方式 GB/T 7714	Linneweber G.A.,Andriatsilavo M.,Dutta S.B.,et al. A neurodevelopmental origin of behavioral individuality in the Drosophila visual system[J]. Science,2020,367(6482).
APA	Linneweber G.A..,Andriatsilavo M..,Dutta S.B..,Bengochea M..,Hellbruegge L..,...&Hassan B.A..(2020).A neurodevelopmental origin of behavioral individuality in the Drosophila visual system.,367(6482).
MLA	Linneweber G.A.,et al."A neurodevelopmental origin of behavioral individuality in the Drosophila visual system".367.6482(2020).