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BSC2 induces multidrug resistance via contributing to the formation of biofilm in Saccharomyces cerevisiae 期刊论文
CELLULAR MICROBIOLOGY, 2021, 卷号: 23, 期号: 12
作者:  Huang, Zhiwei;  Dai, Hongsheng;  Zhang, Xiaoyu;  Wang, Qiao;  Sun, Jing;  Deng, Yunxia;  Shi, Ping
收藏  |  浏览/下载:32/0  |  提交时间:2022/04/28
CELL-WALL  DRUG-RESISTANCE  CANDIDA-ALBICANS  YEAST  PROTEIN  GENES  GLYCOSYLATION  MANNOSYLATION  FLOCCULATION  EXPRESSION  
Human CNS barrier-forming organoids with cerebrospinal fluid production 期刊论文
, 2020, 卷号: 369, 期号: 6500
作者:  Pellegrini L.;  Bonfio C.;  Chadwick J.;  Begum F.;  Skehel M.;  Lancaster M.A.
收藏  |  浏览/下载:40/0  |  提交时间:2020/07/28
blood brain barrier  cell culture technique  cerebrospinal fluid  choroid plexus  gene expression profiling  human  metabolism  organoid  physiology  protein cerebrospinal fluid level  proteomics  single cell analysis  Blood-Brain Barrier  Cell Culture Techniques  Cerebrospinal Fluid  Cerebrospinal Fluid Proteins  Choroid Plexus  Gene Expression Profiling  Humans  Organoids  Proteomics  Single-Cell Analysis  
T cells with dysfunctional mitochondria induce multimorbidity and premature senescence 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Desdín-Micó G.;  Soto-Heredero G.;  Aranda J.F.;  Oller J.;  Carrasco E.;  Gabandé-Rodríguez E.;  Blanco E.M.;  Alfranca A.;  Cussó L.;  Desco M.;  Ibañez B.;  Gortazar A.R.;  Fernández-Marcos P.;  Navarro M.N.;  Hernaez B.;  Alcamí A.;  Baixauli F.;  Mittelbrunn M.
收藏  |  浏览/下载:45/0  |  提交时间:2020/07/28
cardiovascular disease  enzyme activity  gene expression  metabolism  mitochondrial DNA  morbidity  senescence  tumor  Mus  DNA binding protein  mitochondrial protein  mitochondrial transcription factor A  nicotinamide adenine dinucleotide  transcription factor  tumor necrosis factor  animal  cytokine release syndrome  female  fitness  gene deletion  genetics  immunology  inflammation  longevity  male  metabolism  mitochondrion  mouse  multiple chronic conditions  mutant mouse strain  premature aging  T lymphocyte  ultrastructure  Aging, Premature  Animals  Cytokine Release Syndrome  DNA-Binding Proteins  Female  Gene Deletion  Inflammation  Longevity  Male  Mice  Mice, Mutant Strains  Mitochondria  Mitochondrial Proteins  Multimorbidity  NAD  Physical Fitness  T-Lymphocytes  Transcription Factors  Tumor Necrosis Factor-alpha  
Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Khamsi R.
收藏  |  浏览/下载:47/0  |  提交时间:2020/07/28
ruxolitinib  STAT3 protein  antineoplastic agent  transcription factor  algorithm  cancer  computer simulation  disease treatment  drug development  medicine  Article  cancer cell  cancer radiotherapy  enzyme inhibition  gene activity  gene expression regulation  gene interaction  gene mutation  gene repression  gene targeting  human  laboratory test  malignant neoplasm  molecular dynamics  nonhuman  oncologist  priority journal  RNA sequencing  algorithm  genetics  mutation  neoplasm  personalized medicine  procedures  systems biology  Algorithms  Antineoplastic Agents  Humans  Mutation  Neoplasms  Precision Medicine  Systems Biology  Transcription Factors  
Transcription factor AP2 controls cnidarian germ cell induction 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  DuBuc T.Q.;  Schnitzler C.E.;  Chrysostomou E.;  McMahon E.T.;  Febrimarsa;  Gahan J.M.;  Buggie T.;  Gornik S.G.;  Hanley S.;  Barreira S.N.;  Gonzalez P.;  Baxevanis A.D.;  Frank U.
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/28
transcription factor  transcription factor AP2  unclassified drug  clonal organism  gene expression  germ cell  invertebrate  physiological response  protein  adult  Article  cell fate  Cnidaria  embryo  female  genotype  germ cell  gonad development  Hydractinia symbiolongicarpus  male  nonhuman  phenotype  priority journal  protein expression  wild type  Animalia  Bilateria  Hydractinia symbiolongicarpus  Mammalia  
Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Weber C.;  Zhou Y.;  Lee J.G.;  Looger L.L.;  Qian G.;  Ge C.;  Capel B.
收藏  |  浏览/下载:35/0  |  提交时间:2020/07/28
STAT3 protein  calcium  histone demethylase  STAT3 protein  embryonic development  gene expression  sex determination  temperature effect  turtle  animal cell  animal experiment  Article  binding site  calcium transport  cell activation  chromatin immunoprecipitation  controlled study  dimerization  Dmrt1 gene  embryo  embryo development  environmental temperature  epigenetic repression  female  gene  gene activation  gene interaction  gene targeting  genetic transcription  gonad  high temperature  immunofluorescence test  Kdm6b gene  male  nonhuman  priority journal  protein phosphorylation  real time polymerase chain reaction  sex determination  signal transduction  temperature dependence  thermoregulation  transcription regulation  upregulation  Western blotting  animal  embryology  gene expression regulation  genetics  metabolism  phosphorylation  sex determination process  temperature  turtle  Reptilia  Trachemys scripta  Trachemys scripta elegans  Animals  Calcium  Female  Gene Expression Regulation, Developmental  Jumonji Domain-Containing Histone Demethylases  Male  Phosphorylation  Sex Determination Processes  STAT3 Transcription Factor  Temperature  Transcription, Genetic  Turtles  
Structural basis of Gs and Gi recognition by the human glucagon receptor 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Qiao A.;  Han S.;  Li X.;  Li Z.;  Zhao P.;  Dai A.;  Chang R.;  Tai L.;  Tan Q.;  Chu X.;  Ma L.;  Thorsen T.S.;  Reedtz-Runge S.;  Yang D.;  Wang M.-W.;  Sexton P.M.;  Wootten D.;  Sun F.;  Zhao Q.;  Wu B.
收藏  |  浏览/下载:44/0  |  提交时间:2020/07/28
cyclic AMP  glucagon  glucagon receptor  inhibitory guanine nucleotide binding protein  stimulatory guanine nucleotide binding protein  glucagon receptor  inhibitory guanine nucleotide binding protein  protein binding  stimulatory guanine nucleotide binding protein  chemical binding  enzyme activity  gene expression  mutagenicity  protein  alpha helix  Article  binding affinity  carboxy terminal sequence  conformational transition  cryoelectron microscopy  human  molecular recognition  mutagenesis  priority journal  protein binding  protein function  protein protein interaction  protein structure  signal transduction  binding site  chemistry  metabolism  molecular model  protein conformation  ultrastructure  Binding Sites  Cryoelectron Microscopy  Glucagon  GTP-Binding Protein alpha Subunits, Gi-Go  GTP-Binding Protein alpha Subunits, Gs  Humans  Models, Molecular  Protein Binding  Protein Conformation  Protein Conformation, alpha-Helical  Receptors, Glucagon  Signal Transduction  
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Zhou Z.;  He H.;  Wang K.;  Shi X.;  Wang Y.;  Su Y.;  Wang Y.;  Li D.;  Liu W.;  Zhang Y.;  Shen L.;  Han W.;  Shen L.;  Ding J.;  Shao F.
收藏  |  浏览/下载:43/0  |  提交时间:2020/07/28
cell  cell component  cytology  enzyme  enzyme activity  gene expression  immunity  tumor  Mus  gamma interferon  granzyme  GSDMB protein, human  GZMA protein, human  pore forming cytotoxic protein  tumor protein  animal  Bagg albino mouse  chemistry  cytotoxic T lymphocyte  enzymology  genetics  HEK293 cell line  human  immunology  metabolism  mouse  natural killer cell  neoplasm  pathology  protein degradation  protein domain  pyroptosis  transgenic mouse  Animals  Granzymes  HEK293 Cells  Humans  Interferon-gamma  Killer Cells, Natural  Mice  Mice, Inbred BALB C  Mice, Transgenic  Neoplasm Proteins  Neoplasms  Pore Forming Cytotoxic Proteins  Protein Domains  Proteolysis  Pyroptosis  T-Lymphocytes, Cytotoxic  
Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Bessman N.J.;  Mathieu J.R.R.;  Renassia C.;  Zhou L.;  Fung T.C.;  Fernandez K.C.;  Austin C.;  Moeller J.B.;  Zumerle S.;  Louis S.;  Vaulont S.;  Ajami N.J.;  Sokol H.;  Putzel G.G.;  Arvedson T.;  Sockolow R.E.;  Lakhal-Littleton S.;  Cloonan S.M.;  Arora M.;  Peyssonnaux C.;  Sonnenberg G.F.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
ferroportin  hepcidin  iron  cation transport protein  Hamp protein, mouse  hepcidin  iron  metal transporting protein 1  cell  digestive system disorder  immunity  iron  microorganism  animal cell  animal experiment  animal model  animal tissue  Article  controlled study  dendritic cell  enteritis  healing  immunity  intestine flora  intestine injury  iron blood level  iron homeostasis  iron metabolism  iron sequestration  mouse  mucosal healing  mucosal immunity  nonhuman  nutritional immunity  phagocyte  priority journal  protein expression  tissue regeneration  tissue repair  animal  dendritic cell  enteropathy  fecal microbiota transplantation  gene deletion  genetics  homeostasis  intestine mucosa  metabolism  microbiology  mutant mouse strain  physiology  Mus  Animals  Cation Transport Proteins  Dendritic Cells  Fecal Microbiota Transplantation  Gastrointestinal Microbiome  Gene Deletion  Hepcidins  Homeostasis  Intestinal Diseases  Intestinal Mucosa  Iron  Mice  Mice, Mutant Strains  Phagocytes  
Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Lepack A.E.;  Werner C.T.;  Stewart A.F.;  Fulton S.L.;  Zhong P.;  Farrelly L.A.;  Smith A.C.W.;  Ramakrishnan A.;  Lyu Y.;  Bastle R.M.;  Martin J.A.;  Mitra S.;  O'Connor R.M.;  Wang Z.-J.;  Molina H.;  Turecki G.;  Shen L.;  Yan Z.;  Calipari E.S.;  Dietz D.M.;  Kenny P.J.;  Maze I.
收藏  |  浏览/下载:51/0  |  提交时间:2020/07/28
amidase  dopamine  histone H3  histone transamidase  protein glutamine gamma glutamyltransferase 2  RNA  unclassified drug  brain  cell  chemical compound  chemical reaction  gene expression  genetic analysis  protein  action potential  amino acid substitution  amino terminal sequence  Article  cocaine dependence  controlled study  dopamine release  dopaminergic nerve cell  dopaminergic transmission  down regulation  drug seeking behavior  enzyme activity  gene expression  histone dopaminylation  histone modification  human  human tissue  hyperpolarization  in vitro study  motivation  nerve cell plasticity  nerve projection  neuropathology  nucleus accumbens  priority journal  protein expression  protein function  reward  RNA sequence  ventral tegmentum  Rattus