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| Induction of core symptoms of autism spectrum disorder by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys 期刊论文
Science Bulletin, 2021
作者: Wu S.-H.; Li X.; Qin D.-D.; Zhang L.-H.; Cheng T.-L.; Chen Z.-F.; Nie B.-B.; Ren X.-F.; Wu J.; Wang W.-C.; Hu Y.-Z.; Gu Y.-L.; Lv L.-B.; Yin Y.; Hu X.-T.; Qiu Z.-L.
  收藏 | 浏览/下载：31/0 | 提交时间：2021/09/01
Autism spectrum disorders Disease model Gene-editing Nonhuman primate model |
| Generation of nonhuman primate retinitis pigmentosa model by in situ knockout of RHO in rhesus macaque retina 期刊论文
Science Bulletin, 2021, 卷号: 66, 期号: 4
作者: Li S.; Hu Y.; Li Y.; Hu M.; Wang W.; Ma Y.; Cai Y.; Wei M.; Yao Y.; Wang Y.; Dong K.; Gu Y.; Zhao H.; Bao J.; Qiu Z.; Zhang M.; Hu X.; Xue T.
收藏 | 浏览/下载：56/0 | 提交时间：2021/09/01
Disease model Gene editing Nonhuman primate model Retinitis pigmentosa Rhodopsin SaCas9 |
| CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Muendlein H.I.; Jetton D.; Connolly W.M.; Eidell K.P.; Magri Z.; Smirnova I.; Poltorak A.
收藏 | 浏览/下载：49/0 | 提交时间：2020/07/28
FLICE inhibitory protein interleukin 1beta lipopolysaccharide messenger RNA succinate dehydrogenase (ubiquinone) Casp1 protein, mouse caspase 8 Cflar protein, mouse cryopyrin FLICE inhibitory protein IL1B protein, mouse inflammasome interleukin 1beta interleukin 1beta converting enzyme lipopolysaccharide succinate dehydrogenase (ubiquinone) cell enzyme activity inhibition maturation protein animal cell animal experiment Article bone marrow derived macrophage cell death cell protection complex formation controlled study cytokine release in vitro study inflammation mouse nonhuman priority journal protein analysis protein degradation protein function protein interaction pyroptosis animal gene knockdown genetics immunology macrophage macrophage activation metabolism physiology Murinae Animals CASP8 and FADD-Like Apoptosis Regulating Protein Caspase 1 Caspase 8 Electron Transport Complex II Gene Knockdown Techniques Inflammasomes Interleukin-1beta Lipopolysaccharides Macrophage Activation Macrophages Mice NLR Family, Pyrin Domain-Containing 3 Protein Pyroptosis |
| Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Khamsi R.
收藏 | 浏览/下载：47/0 | 提交时间：2020/07/28
ruxolitinib STAT3 protein antineoplastic agent transcription factor algorithm cancer computer simulation disease treatment drug development medicine Article cancer cell cancer radiotherapy enzyme inhibition gene activity gene expression regulation gene interaction gene mutation gene repression gene targeting human laboratory test malignant neoplasm molecular dynamics nonhuman oncologist priority journal RNA sequencing algorithm genetics mutation neoplasm personalized medicine procedures systems biology Algorithms Antineoplastic Agents Humans Mutation Neoplasms Precision Medicine Systems Biology Transcription Factors |
| Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者: Guthrie L.M.; Soma S.; Yuan S.; Silva A.; Zulkifli M.; Snavely T.C.; Greene H.F.; Nunez E.; Lynch B.; de Ville C.; Shanbhag V.; Lopez F.R.; Acharya A.; Petris M.J.; Kim B.-E.; Gohil V.M.; Sacchettini J.C.
收藏 | 浏览/下载：37/0 | 提交时间：2020/07/28
copper copper zinc superoxide dismutase cytochrome c oxidase dopamine beta monooxygenase elesclomol monophenol monooxygenase protein lysine 6 oxidase copper cytochrome c oxidase elesclomol hydrazine derivative copper cytochrome enzyme enzyme activity mitochondrion mortality mutation pathology rodent survival animal cell animal experiment animal model animal tissue Article cohort analysis controlled study disease severity drug mechanism Golgi complex H9c2(2-1) cell line in vivo study male Menkes syndrome mitochondrial dynamics mortality rate mouse nerve degeneration nonhuman priority journal secretory pathway survival rate animal brain cell line degenerative disease disease model drug effect genetics knockout mouse Menkes syndrome metabolism mitochondrion pathology rat transport at the cellular level Murinae Mus Animals Biological Transport Brain Cell Line Copper Copper Transporter 1 Disease Models, Animal Electron Transport Complex IV Hydrazines Male Menkes Kinky Hair Syndrome Mice Mice, Knockout Mitochondria Neurodegenerative Diseases Rats |
| Intravital imaging of mouse embryos 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Huang Q.; Cohen M.A.; Alsina F.C.; Devlin G.; Garrett A.; McKey J.; Havlik P.; Rakhilin N.; Wang E.; Xiang K.; Mathews P.; Wang L.; Bock C.; Ruthig V.; Wang Y.; Negrete M.; Wong C.W.; Murthy P.K.L.; Zhang S.; Daniel A.R.; Kirsch D.G.; Kang Y.; Capel B.; Asokan A.; Silver D.L.; Jaenisch R.; Shen X.
收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
cell embryo embryonic development imaging method physiology animal cell animal experiment article autophagy (cellular) brain cell cell division chimera controlled study diffusion electroporation embryo female microscopy mouse mouse embryo neural crest cell neurotransmission nonhuman placenta retina uterus vascularization viral gene delivery system |
| A parapithecid stem anthropoid of African origin in the Paleogene of South America 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Seiffert E.R.; Tejedor M.F.; Fleagle J.G.; Novo N.M.; Cornejo F.M.; Bond M.; De Vries D.; Campbell K.E.
收藏 | 浏览/下载：12/0 | 提交时间：2020/07/28
cladistics dispersal Eocene-Oligocene boundary new record Paleogene phylogenetics primate rodent article cladistics Eocene nonhuman Oligocene phylogeny primate sea level South America Africa Amazonia Arabian Peninsula Arabian Peninsula Guatemala [Central America] Peru Santa Rosa South America Western Hemisphere Caviomorpha Mammalia Parapithecidae Primates Rodentia Simiiformes |
| Transcription polymerase-catalyzed emergence of novel RNA replicons 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Jain N.; Blauch L.R.; Szymanski M.R.; Das R.; Tang S.K.Y.; Yin Y.W.; Fire A.Z.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
cell component enzyme enzyme activity genetic analysis RNA article bacteriophage catalysis DNA replication origin heredity in vitro study nonhuman plant seed replicon RNA replication synthesis transcription initiation biocatalysis biosynthesis genetic transcription metabolism Animalia Hepatitis delta virus Viroids bacteriophage T7 RNA polymerase DNA directed RNA polymerase RNA viral protein Biocatalysis DNA-Directed RNA Polymerases Replicon RNA Transcription, Genetic Viral Proteins |
| Widespread receptor-driven modulation in peripheral olfactory coding 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Xu L.; Li W.; Voleti V.; Zou D.-J.; Hillman E.M.C.; Firestein S.
收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
antagonism cell component detection method odor olfaction protein animal cell animal experiment article excitation high throughput analysis male microscopy mouse nonhuman odor olfactory epithelium olfactory receptor neuron animal confocal microscopy innervation mutant mouse strain olfactory mucosa physiology single cell analysis acetophenone acetophenone derivative benzyl acetate benzyl derivative citral fragrance Acetophenones Acyclic Monoterpenes Animals Benzyl Compounds Mice Mice, Mutant Strains Microscopy, Confocal Odorants Olfactory Mucosa Olfactory Receptor Neurons Single-Cell Analysis Smell |
| A neurodevelopmental origin of behavioral individuality in the Drosophila visual system 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Linneweber G.A.; Andriatsilavo M.; Dutta S.B.; Bengochea M.; Hellbruegge L.; Liu G.; Ejsmont R.K.; Straw A.D.; Wernet M.; Hiesinger P.R.; Hassan B.A.
收藏 | 浏览/下载：50/0 | 提交时间：2020/07/28
anatomy asymmetry brain genome neurology orientation visual analysis article brain Drosophila melanogaster human experiment individuality nerve cell nonhuman stochastic model visual system walking anatomy and histology animal Drosophila melanogaster genetic variation genetics growth, development and aging nervous system development orientation physiology visual field visual system Drosophila melanogaster Animals Brain Drosophila melanogaster Genetic Variation Individuality Neurogenesis Orientation Visual Fields Visual Pathways |
