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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Zhou Z.;  He H.;  Wang K.;  Shi X.;  Wang Y.;  Su Y.;  Wang Y.;  Li D.;  Liu W.;  Zhang Y.;  Shen L.;  Han W.;  Shen L.;  Ding J.;  Shao F.
收藏  |  浏览/下载:29/0  |  提交时间:2020/07/28
cell  cell component  cytology  enzyme  enzyme activity  gene expression  immunity  tumor  Mus  gamma interferon  granzyme  GSDMB protein, human  GZMA protein, human  pore forming cytotoxic protein  tumor protein  animal  Bagg albino mouse  chemistry  cytotoxic T lymphocyte  enzymology  genetics  HEK293 cell line  human  immunology  metabolism  mouse  natural killer cell  neoplasm  pathology  protein degradation  protein domain  pyroptosis  transgenic mouse  Animals  Granzymes  HEK293 Cells  Humans  Interferon-gamma  Killer Cells, Natural  Mice  Mice, Inbred BALB C  Mice, Transgenic  Neoplasm Proteins  Neoplasms  Pore Forming Cytotoxic Proteins  Protein Domains  Proteolysis  Pyroptosis  T-Lymphocytes, Cytotoxic  
Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells 期刊论文
, 2020, 卷号: 368, 期号: 6493
作者:  Bálint Š.;  Müller S.;  Fischer R.;  Kessler B.M.;  Harkiolaki M.;  Valitutti S.;  Dustin M.L.
收藏  |  浏览/下载:45/0  |  提交时间:2020/07/28
cancer  cell  identification method  molecular analysis  reconstruction  granzyme  multiprotein complex  perforin  thrombospondin 1  CRISPR Cas system  cytotoxic T lymphocyte  cytotoxicity  exocytosis  gene editing  genetics  human  K-562 cell line  metabolism  x-ray tomography  CRISPR-Cas Systems  Cytotoxicity, Immunologic  Exocytosis  Gene Editing  Granzymes  Humans  K562 Cells  Multiprotein Complexes  Perforin  T-Lymphocytes, Cytotoxic  Thrombospondin 1  Tomography, X-Ray