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| Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者: Dai W.; Zhang B.; Jiang X.-M.; Su H.; Li J.; Zhao Y.; Xie X.; Jin Z.; Peng J.; Liu F.; Li C.; Li Y.; Bai F.; Wang H.; Cheng X.; Cen X.; Hu S.; Yang X.; Wang J.; Liu X.; Xiao G.; Jiang H.; Rao Z.; Zhang L.-K.; Xu Y.; Yang H.; Liu H.
  收藏 | 浏览/下载：45/0 | 提交时间：2020/07/28
aldehyde antimicrobial activity drug enzyme activity infectivity inhibitor reaction kinetics viral disease Coronavirus SARS coronavirus 3C-like proteinase, Coronavirus antivirus agent cysteine proteinase viral protein animal Betacoronavirus chemical structure chemistry Chlorocebus aethiops Coronavirus infection dog drug design drug effect enzyme active site enzymology female human male mouse pandemic preclinical study protein tertiary structure Sprague Dawley rat toxicity testing Vero cell line virus pneumonia Animals Antiviral Agents Betacoronavirus Catalytic Domain Chlorocebus aethiops Coronavirus Infections Cysteine Endopeptidases Dogs Drug Design Drug Evaluation, Preclinical Female Humans Male Mice Molecular Structure Pandemics Pneumonia, Viral Protein Structure, Tertiary Rats, Sprague-Dawley Toxicity Tests Vero Cells Viral Nonstructural Proteins |
| PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Wang Q.; Boshoff H.I.M.; Harrison J.R.; Ray P.C.; Green S.R.; Wyatt P.G.; Barry Iii C.E.
收藏 | 浏览/下载：28/0 | 提交时间：2020/07/28
3,3 bis di(methylsulfonyl)propionamide antiinfective agent bacterial protein glucose glycerol magnesium phosphate propionamide derivative protein proline proline glutamate protein proline proline glutamate 51 unclassified drug amide bacterial protein lipid phthiocerol dimycocerosate propionamide thiol derivative cell component chemical compound membrane mutation protein tuberculosis antibiotic resistance Article bacterial cell bacterial cell wall bacterial growth bacterial outer membrane cell division drug structure Mycobacterium tuberculosis nonhuman nutrient uptake priority journal protein depletion cell membrane cell membrane permeability chemistry drug effect gene deletion genetics metabolism transport at the cellular level Mycobacterium tuberculosis Amides Bacterial Proteins Biological Transport Cell Membrane Cell Membrane Permeability Drug Resistance, Bacterial Gene Deletion Glucose Glycerol Lipids Mycobacterium tuberculosis Sulfhydryl Compounds |
| Fluorination of arylboronic esters enabled by bismuth redox catalysis 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者: Planas O.; Wang F.; Leutzsch M.; Cornella J.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
aryl boronic ester aryl fluoride bismine bismuth bismuth derivative boronic acid derivative chloride chlorobismine difluorobismine ester fluoride fluorobenzene fluorobismine iron naphthalene ortho bromide pentavalent pentavalent bismine phenylboronic acid pinacol ester sulfone tetrafluoroborate bismine transition element trifluoromethyl trimethylsilyl derivative unclassified drug unindexed drug vinyl derivative bismuth catalysis catalyst crystallography ester ligand optimization oxidation redox potential transition element Article catalysis chemical bond crystal structure crystallography elimination reaction fluorination metallation oxidation reduction reaction oxidative coupling priority journal reaction analysis reaction optimization reduction (chemistry) transmetallation |
| Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Walton R.T.; Christie K.A.; Whittaker M.N.; Kleinstiver B.P.
收藏 | 浏览/下载：27/0 | 提交时间：2020/07/28
adenine adenosine CRISPR associated endonuclease Cas9 cytosine guanosine SpG protein SpRY nuclease thymine unclassified drug Cas9 endonuclease Streptococcus pyogenes bacterium enzyme activity genetic engineering genetic variation genome Article CRISPR-CAS9 system DNA sequence enzyme activity gene editing gene targeting genetic variability human mutagenesis nonhuman priority journal protein engineering protein motif protein structure protospacer adjacent motif Streptococcus pyogenes chemistry CRISPR Cas system enzyme specificity gene editing gene targeting genetic predisposition genetics HEK293 cell line procedures protein domain Streptococcus pyogenes CRISPR-Associated Protein 9 CRISPR-Cas Systems Gene Editing Gene Targeting Genetic Predisposition to Disease HEK293 Cells Humans Mutagenesis Protein Domains Substrate Specificity |
| Structure of the secretory immunoglobulin A core 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者: Kumar N.; Arthur C.P.; Ciferri C.; Matsumoto M.L.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
dimer immunoglobulin receptor oligomer pentamer secretory component secretory immunoglobulin tetramer unclassified drug antibody immune response immunity pathogen physiological response protein secretion antigen antibody complex antigen binding Article cryoelectron microscopy human immune reconstitution immunity immunoglobulin structure oligomerization priority journal transcytosis |
| Aminoalkyl radicals as halogen-atom transfer agents for activation of alkyl and aryl halides 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者: Constantin T.; Zanini M.; Regni A.; Sheikh N.S.; Juliá F.; Leonori D.
收藏 | 浏览/下载：41/0 | 提交时间：2020/07/28
alkyl halide aryl halide halide halogen unclassified drug chemistry halogen radical tributyltin alkylation amino acid transport Article atom transfer radical polymerization catalysis chemical analysis chemical bond chemical reaction chemical structure electron transport photolysis priority journal |
| Evidence for an edge supercurrent in the Weyl superconductor MoTe2 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者: Wang W.; Kim S.; Liu M.; Cevallos F.A.; Cava R.J.; Ong N.P.
收藏 | 浏览/下载：38/0 | 提交时间：2020/07/28
metal molybdenum ditellurid unclassified drug crystal structure frequency analysis magnetic field molybdenum superconductivity topology Article electric current Fraunhofer oscillation magnetic field mathematical computing mathematical model oscillation priority journal superconductivity |
| Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: He S.; Wu Z.; Tian Y.; Yu Z.; Yu J.; Wang X.; Li J.; Liu B.; Xu Y.
收藏 | 浏览/下载：38/0 | 提交时间：2020/07/28
actin related protein adenosine triphosphatase BRG1 BRM associated factor DNA multiprotein complex protein SWI retinoblastoma binding protein 2 SMARCC protein SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1 transcription factor transcription factor SNF unclassified drug cancer enzyme activity gene expression hydrolysis mutation protein alpha helix Article carboxy terminal sequence cell interaction cryoelectron microscopy disease association human malignant neoplasm molecular recognition mutation nucleosome priority journal protein function protein hydrolysis protein structure structure analysis Mammalia |
| TTC5 mediates autoregulation of tubulin via mRNA degradation 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者: Lin Z.; Gasic I.; Chandrasekaran V.; Peters N.; Shao S.; Mitchison T.J.; Hegde R.S.
收藏 | 浏览/下载：26/0 | 提交时间：2020/07/28
messenger RNA mutant protein polypeptide recombinant protein regulator protein tetratricopeptide protein 5 tubulin unclassified drug biodegradation chromosome peptide protein RNA amino terminal sequence animal cell Article autoregulation binding site chromosome segregation controlled study cryoelectron microscopy genetic code human human cell Leporidae mitosis molecular model nonhuman priority journal protein analysis protein binding protein interaction protein structure reticulocyte ribosome RNA degradation RNA translation tubulin gene |
| Disassembling 2D van der Waals crystals into macroscopic monolayers and reassembling into artificial lattices 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Liu F.; Wu W.; Bai Y.; Chae S.H.; Li Q.; Wang J.; Hone J.; Zhu X.-Y.
收藏 | 浏览/下载：29/0 | 提交时间：2020/07/28
chemical compound transition metal dichalcogenide unclassified drug chemical bonding crystal chemistry layer symmetry transition element two-dimensional modeling Article broken inversion symmetry bulk crystal size chemical procedures chemical structure complex formation controlled study crystal crystal monolayer crystal structure high throughput analysis histogram image analysis particle size physical parameters priority journal quality control Scotch tape exfoliation two dimensional structure van der Waals crystal |
