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The role of herbivory in the macroevolution of vertebrate hormone dynamics 期刊论文
Ecology Letters, 2020, 卷号: 23, 期号: 9
作者:  Edwards P.D.;  Sookhan N.;  Boonstra R.
收藏  |  浏览/下载：37/0  |  提交时间：2021/09/01
Chemical ecology  comparative biology  corticosteroid-binding globulin  cortisol  glucocorticoids  herbivory  phytochemicals  plant-herbivore interactions  secondary plant compounds  
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Yuan M.;  Wu N.C.;  Zhu X.;  Lee C.-C.D.;  So R.T.Y.;  Lv H.;  Mok C.K.P.;  Wilson I.A.
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  epitope  neutralizing antibody  virus hemagglutinin  virus spike protein  angiotensin converting enzyme 2  coronavirus receptors  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  neutralizing antibody  spike glycoprotein, SARS-CoV  spike protein, SARS-CoV-2  virus antibody  virus antigen  virus receptor  antibody  antigen  chemical binding  crystal structure  protein  respiratory disease  viral disease  virus  amino terminal sequence  antibody isolation  antigen binding  antigenicity  Article  binding affinity  binding site  conservation biology  controlled study  coronavirus disease 2019  cross reaction  cryoelectron microscopy  crystal structure  enzyme linked immunosorbent assay  epidemic  glycosylation  human  hydrophobicity  immune response  in vitro study  in vivo study  light chain  nonhuman  priority journal  protein conformation  protein domain  protein interaction  protein localization  protein structure  protein targeting  receptor binding  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  antibody affinity  Betacoronavirus  binding site  chemistry  immunology  metabolism  molecular model  SARS coronavirus  X ray crystallography  Coronavirus  SARS coronavirus  Amino Acid Sequence  Antibodies, Neutralizing  Antibodies, Viral  Antibody Affinity  Antigens, Viral  Betacoronavirus  Binding Sites  Cross Reactions  Crystallography, X-Ray  Epitopes  Models, Molecular  Peptidyl-Dipeptidase A  Protein Conformation  Protein Domains  Protein Interaction Domains and Motifs  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus  
Structural basis of Gs and Gi recognition by the human glucagon receptor 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Qiao A.;  Han S.;  Li X.;  Li Z.;  Zhao P.;  Dai A.;  Chang R.;  Tai L.;  Tan Q.;  Chu X.;  Ma L.;  Thorsen T.S.;  Reedtz-Runge S.;  Yang D.;  Wang M.-W.;  Sexton P.M.;  Wootten D.;  Sun F.;  Zhao Q.;  Wu B.
收藏  |  浏览/下载：44/0  |  提交时间：2020/07/28
cyclic AMP  glucagon  glucagon receptor  inhibitory guanine nucleotide binding protein  stimulatory guanine nucleotide binding protein  glucagon receptor  inhibitory guanine nucleotide binding protein  protein binding  stimulatory guanine nucleotide binding protein  chemical binding  enzyme activity  gene expression  mutagenicity  protein  alpha helix  Article  binding affinity  carboxy terminal sequence  conformational transition  cryoelectron microscopy  human  molecular recognition  mutagenesis  priority journal  protein binding  protein function  protein protein interaction  protein structure  signal transduction  binding site  chemistry  metabolism  molecular model  protein conformation  ultrastructure  Binding Sites  Cryoelectron Microscopy  Glucagon  GTP-Binding Protein alpha Subunits, Gi-Go  GTP-Binding Protein alpha Subunits, Gs  Humans  Models, Molecular  Protein Binding  Protein Conformation  Protein Conformation, alpha-Helical  Receptors, Glucagon  Signal Transduction  
The structure of human CST reveals a decameric assembly bound to telomeric DNA 期刊论文
, 2020, 卷号: 368, 期号: 6495
作者:  Lim C.J.;  Barbour A.T.;  Zaug A.J.;  Goodrich K.J.;  McKay A.E.;  Wuttke D.S.;  Cech T.R.
收藏  |  浏览/下载：24/0  |  提交时间：2020/07/28
carboxylic acid  chemical binding  DNA  genome  microscopy  protein  yeast  
Ancient origins of allosteric activation in a Ser-Thr kinase 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Hadzipasic A.;  Wilson C.;  Nguyen V.;  Kern N.;  Kim C.;  Pitsawong W.;  Villali J.;  Zheng Y.;  Kern D.
收藏  |  浏览/下载：49/0  |  提交时间：2020/07/28
aurora A kinase  microtubule associated protein  TPX2 protein  unclassified drug  activation energy  ancestry  cell  chemical binding  experimental study  fitness  protein  allosterism  amino acid sequence  Article  binding affinity  binding site  enzyme activation  enzyme activity  enzyme binding  enzyme localization  enzyme phosphorylation  gene duplication  horizontal gene transfer  human  hydrophobicity  intracellular signaling  phylogenetic tree  phylogeny  priority journal  protein binding  protein localization  protein protein interaction  
Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Zhang L.;  Zhao Y.;  Gao Y.;  Wu L.;  Gao R.;  Zhang Q.;  Wang Y.;  Wu C.;  Wu F.;  Gurcha S.S.;  Veerapen N.;  Batt S.M.;  Zhao W.;  Qin L.;  Yang X.;  Wang M.;  Zhu Y.;  Zhang B.;  Bi L.;  Zhang X.;  Yang H.;  Guddat L.W.;  Xu W.;  Wang Q.;  Li J.;  Besra G.S.;  Rao Z.
收藏  |  浏览/下载：42/0  |  提交时间：2020/07/28
biochemistry  cell component  chemical binding  detection method  drug  drug resistance  enzyme  enzyme activity  inhibition  mutation  Mycobacterium tuberculosis  arabinosyltransferase  ethambutol  glycosyltransferase  tuberculostatic agent  cell wall  chemistry  cryoelectron microscopy  enzymology  multidrug resistance  Mycobacterium tuberculosis  protein conformation  Antitubercular Agents  Cell Wall  Cryoelectron Microscopy  Drug Resistance, Multiple, Bacterial  Ethambutol  Mycobacterium tuberculosis  Pentosyltransferases  Protein Conformation  
Critical differences in 3D atomic structure of individual ligand-protected nanocrystals in solution 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者:  Kim B.H.;  Heo J.;  Kim S.;  Reboul C.F.;  Chun H.;  Kang D.;  Bae H.;  Hyun H.;  Lim J.;  Lee H.;  Han B.;  Hyeon T.;  Paul Alivisatos A.;  Ercius P.;  Elmlund H.;  Park J.
收藏  |  浏览/下载：53/0  |  提交时间：2020/07/28
ligand  nanocrystal  platinum nanoparticle  crystal structure  electron microscopy  lattice dynamics  ligand  nanoparticle  three-dimensional modeling  Article  atom  catalysis  chemical binding  chemical composition  chemical procedures  concentration (parameter)  crystal structure  degradation  electron microscopy  image analysis  liquid crystal  nanoanalysis  priority journal  structure analysis  surface property  synthesis  
Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Suomivuori C.-M.;  Latorraca N.R.;  Wingler L.M.;  Eismann S.;  King M.C.;  Kleinhenz A.L.W.;  Skiba M.A.;  Staus D.P.;  Kruse A.C.;  Lefkowitz R.J.;  Dror R.O.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
angiotensin 1 receptor  beta arrestin 1  beta arrestin 2  G protein coupled receptor  rhodopsin  chemical binding  design method  ligand  molecular analysis  protein  signaling  allosterism  Article  carboxy terminal sequence  conformational transition  controlled study  crystal structure  human  ligand binding  molecular dynamics  priority journal  protein conformation  signal transduction  structural model  
Reconstructing the evolutionary history of nitrogenases: Evidence for ancestral molybdenum-cofactor utilization 期刊论文
, 2020, 卷号: 18, 期号: 3
作者:  Garcia A.K.;  McShea H.;  Kolaczkowski B.;  Kaçar B.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
biogeochemistry  chemical binding  enzyme  evolutionary biology  gene  homology  molybdenum  nitrogen fixation  nutrient availability  phylogenetics  protein  reconstruction  
Pervasive functional translation of noncanonical human open reading frames 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Chen J.;  Brunner A.-D.;  Cogan J.Z.;  Nuñez J.K.;  Fields A.P.;  Adamson B.;  Itzhak D.N.;  Li J.Y.;  Mann M.;  Leonetti M.D.;  Weissman J.S.
收藏  |  浏览/下载：54/0  |  提交时间：2020/07/28
messenger RNA  antigen  cell component  cell organelle  chemical binding  growth  phenotype  protein  Quaternary  RNA  Article  cell function  cell growth  cellular distribution  clustered regularly interspaced short palindromic repeat  gene sequence  genetic screening  HLA system  human  non-canonical base pairing  open reading frame  operon  priority journal  protein analysis  protein binding  protein function  transcriptomics  translation regulation  Mammalia