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| CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Muendlein H.I.; Jetton D.; Connolly W.M.; Eidell K.P.; Magri Z.; Smirnova I.; Poltorak A.
  收藏 | 浏览/下载：49/0 | 提交时间：2020/07/28
FLICE inhibitory protein interleukin 1beta lipopolysaccharide messenger RNA succinate dehydrogenase (ubiquinone) Casp1 protein, mouse caspase 8 Cflar protein, mouse cryopyrin FLICE inhibitory protein IL1B protein, mouse inflammasome interleukin 1beta interleukin 1beta converting enzyme lipopolysaccharide succinate dehydrogenase (ubiquinone) cell enzyme activity inhibition maturation protein animal cell animal experiment Article bone marrow derived macrophage cell death cell protection complex formation controlled study cytokine release in vitro study inflammation mouse nonhuman priority journal protein analysis protein degradation protein function protein interaction pyroptosis animal gene knockdown genetics immunology macrophage macrophage activation metabolism physiology Murinae Animals CASP8 and FADD-Like Apoptosis Regulating Protein Caspase 1 Caspase 8 Electron Transport Complex II Gene Knockdown Techniques Inflammasomes Interleukin-1beta Lipopolysaccharides Macrophage Activation Macrophages Mice NLR Family, Pyrin Domain-Containing 3 Protein Pyroptosis |
| Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者: Guthrie L.M.; Soma S.; Yuan S.; Silva A.; Zulkifli M.; Snavely T.C.; Greene H.F.; Nunez E.; Lynch B.; de Ville C.; Shanbhag V.; Lopez F.R.; Acharya A.; Petris M.J.; Kim B.-E.; Gohil V.M.; Sacchettini J.C.
收藏 | 浏览/下载：37/0 | 提交时间：2020/07/28
copper copper zinc superoxide dismutase cytochrome c oxidase dopamine beta monooxygenase elesclomol monophenol monooxygenase protein lysine 6 oxidase copper cytochrome c oxidase elesclomol hydrazine derivative copper cytochrome enzyme enzyme activity mitochondrion mortality mutation pathology rodent survival animal cell animal experiment animal model animal tissue Article cohort analysis controlled study disease severity drug mechanism Golgi complex H9c2(2-1) cell line in vivo study male Menkes syndrome mitochondrial dynamics mortality rate mouse nerve degeneration nonhuman priority journal secretory pathway survival rate animal brain cell line degenerative disease disease model drug effect genetics knockout mouse Menkes syndrome metabolism mitochondrion pathology rat transport at the cellular level Murinae Mus Animals Biological Transport Brain Cell Line Copper Copper Transporter 1 Disease Models, Animal Electron Transport Complex IV Hydrazines Male Menkes Kinky Hair Syndrome Mice Mice, Knockout Mitochondria Neurodegenerative Diseases Rats |
| Intravital imaging of mouse embryos 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Huang Q.; Cohen M.A.; Alsina F.C.; Devlin G.; Garrett A.; McKey J.; Havlik P.; Rakhilin N.; Wang E.; Xiang K.; Mathews P.; Wang L.; Bock C.; Ruthig V.; Wang Y.; Negrete M.; Wong C.W.; Murthy P.K.L.; Zhang S.; Daniel A.R.; Kirsch D.G.; Kang Y.; Capel B.; Asokan A.; Silver D.L.; Jaenisch R.; Shen X.
收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
cell embryo embryonic development imaging method physiology animal cell animal experiment article autophagy (cellular) brain cell cell division chimera controlled study diffusion electroporation embryo female microscopy mouse mouse embryo neural crest cell neurotransmission nonhuman placenta retina uterus vascularization viral gene delivery system |
| Widespread receptor-driven modulation in peripheral olfactory coding 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Xu L.; Li W.; Voleti V.; Zou D.-J.; Hillman E.M.C.; Firestein S.
收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
antagonism cell component detection method odor olfaction protein animal cell animal experiment article excitation high throughput analysis male microscopy mouse nonhuman odor olfactory epithelium olfactory receptor neuron animal confocal microscopy innervation mutant mouse strain olfactory mucosa physiology single cell analysis acetophenone acetophenone derivative benzyl acetate benzyl derivative citral fragrance Acetophenones Acyclic Monoterpenes Animals Benzyl Compounds Mice Mice, Mutant Strains Microscopy, Confocal Odorants Olfactory Mucosa Olfactory Receptor Neurons Single-Cell Analysis Smell |
| A neurodevelopmental origin of behavioral individuality in the Drosophila visual system 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Linneweber G.A.; Andriatsilavo M.; Dutta S.B.; Bengochea M.; Hellbruegge L.; Liu G.; Ejsmont R.K.; Straw A.D.; Wernet M.; Hiesinger P.R.; Hassan B.A.
收藏 | 浏览/下载：50/0 | 提交时间：2020/07/28
anatomy asymmetry brain genome neurology orientation visual analysis article brain Drosophila melanogaster human experiment individuality nerve cell nonhuman stochastic model visual system walking anatomy and histology animal Drosophila melanogaster genetic variation genetics growth, development and aging nervous system development orientation physiology visual field visual system Drosophila melanogaster Animals Brain Drosophila melanogaster Genetic Variation Individuality Neurogenesis Orientation Visual Fields Visual Pathways |
| Circadian rhythms in the absence of the clock gene Bmal1 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者: Ray S.; Valekunja U.K.; Stangherlin A.; Howell S.A.; Snijders A.P.; Damodaran G.; Reddy A.B.
收藏 | 浏览/下载：27/0 | 提交时间：2020/07/28
phosphoproteome proteome transcription factor ARNTL transcription factor Ets transcriptome unclassified drug cell component circadian rhythm gene gene expression genome molecular analysis animal experiment animal tissue Article Bmal1 gene circadian rhythm controlled study gene deletion gene expression regulation gene function gene knockout genotype knockout mouse light dark cycle liver mouse nonhuman oscillation oxidation reduction potential priority journal RNA sequence skin fibroblast temperature transcription regulation Mammalia Mus |
| Animals as Agents in Fire Regimes 期刊论文
, 2020, 卷号: 35, 期号: 4
作者: Foster C.N.; Banks S.C.; Cary G.J.; Johnson C.N.; Lindenmayer D.B.; Valentine L.E.
收藏 | 浏览/下载：220/0 | 提交时间：2020/07/28
animal community ecosystem engineering landscape ecology wildfire wind velocity Animalia animal experiment animal model ecosystem nonhuman quantitative analysis review wind speed |
| Arctic-adapted dogs emerged at the Pleistocene-Holocene transition 期刊论文
, 2020, 卷号: 368, 期号: 6498
作者: Sinding M.-H.S.; Gopalakrishnan S.; Ramos-Madrigal J.; de Manuel M.; Pitulko V.V.; Kuderna L.; Feuerborn T.R.; Frantz L.A.F.; Vieira F.G.; Niemann J.; Samaniego Castruita J.A.; Carøe C.; Andersen-Ranberg E.U.; Jordan P.D.; Pavlova E.Y.; Nikolskiy P.A.; Kasparov A.K.; Ivanova V.V.; Willerslev E.; Skoglund P.; Fredholm M.; Wennerberg S.E.; Heide-Jørgensen M.P.; Dietz R.; Sonne C.; Meldgaard M.; Dalén L.; Larson G.; Petersen B.; Sicheritz-Pontén T.; Bachmann L.; Wiig Ø.; Marques-Bonet T.; Hansen A.J.; Gilbert M.T.P.
收藏 | 浏览/下载：54/0 | 提交时间：2020/07/28
adult animal experiment Arctic article attention gene flow genetic similarity Greenland haplotype Holocene nonhuman Pleistocene Russian Federation sled dog wolf |
| Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Weber C.; Zhou Y.; Lee J.G.; Looger L.L.; Qian G.; Ge C.; Capel B.
收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
STAT3 protein calcium histone demethylase STAT3 protein embryonic development gene expression sex determination temperature effect turtle animal cell animal experiment Article binding site calcium transport cell activation chromatin immunoprecipitation controlled study dimerization Dmrt1 gene embryo embryo development environmental temperature epigenetic repression female gene gene activation gene interaction gene targeting genetic transcription gonad high temperature immunofluorescence test Kdm6b gene male nonhuman priority journal protein phosphorylation real time polymerase chain reaction sex determination signal transduction temperature dependence thermoregulation transcription regulation upregulation Western blotting animal embryology gene expression regulation genetics metabolism phosphorylation sex determination process temperature turtle Reptilia Trachemys scripta Trachemys scripta elegans Animals Calcium Female Gene Expression Regulation, Developmental Jumonji Domain-Containing Histone Demethylases Male Phosphorylation Sex Determination Processes STAT3 Transcription Factor Temperature Transcription, Genetic Turtles |
| Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Uckelmann H.J.; Kim S.M.; Wong E.M.; Hatton C.; Giovinazzo H.; Gadrey J.Y.; Krivtsov A.V.; Rücker F.G.; Döhner K.; McGeehan G.M.; Levine R.L.; Bullinger L.; Vassiliou G.S.; Armstrong S.A.
收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
antileukemic agent methionine unclassified drug vtp 50469 biological development cancer cell disease treatment mutation numerical model oral health acute myeloid leukemia animal cell animal experiment animal model antineoplastic activity Article cell proliferation cell self-renewal chromatin controlled study drug targeting gene gene mutation leukemia cell molecularly targeted therapy mouse mouse model nonhuman NPM1 gene preleukemia priority journal Mus |
