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| The Ccr4-Not complex monitors the translating ribosome for codon optimality 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Buschauer R.; Matsuo Y.; Sugiyama T.; Chen Y.-H.; Alhusaini N.; Sweet T.; Ikeuchi K.; Cheng J.; Matsuki Y.; Nobuta R.; Gilmozzi A.; Berninghausen O.; Tesina P.; Becker T.; Coller J.; Inada T.; Beckmann R.
  收藏 | 浏览/下载：46/0 | 提交时间：2020/07/28
exonuclease initiation factor 5A messenger RNA ribosome RNA transfer RNA ubiquitin protein ligase E3 bioassay biomonitoring cell component plant and fungus structure and form 40S ribosomal subunit adenylation amino terminal sequence Article binding site biochemical analysis carbon catabolite repressor 4 negative on tata complex codon complex formation controlled study cryoelectron microscopy homeostasis molecular interaction nonhuman priority journal protein conformation ribosome Saccharomyces cerevisiae sequence analysis ubiquitination Saccharomyces cerevisiae |
| Valence and patterning of aromatic residues determine the phase behavior of prion-like domains 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者: Martin E.W.; Holehouse A.S.; Peran I.; Farag M.; Incicco J.J.; Bremer A.; Grace C.R.; Soranno A.; Pappu R.V.; Mittag T.
收藏 | 浏览/下载：21/0 | 提交时间：2020/07/28
aromatic hydrocarbon biophysics concentration (composition) genetic analysis nuclear magnetic resonance prion disease protein separation temperature effect article nonhuman nuclear magnetic resonance spectroscopy phase separation prediction prion simulation X ray crystallography amino acid sequence chemistry phase transition prion protein domain small angle scattering X ray diffraction heterogeneous nuclear ribonucleoprotein A1 phenylalanine tyrosine Amino Acid Sequence Heterogeneous Nuclear Ribonucleoprotein A1 Magnetic Resonance Spectroscopy Phase Transition Phenylalanine Prions Protein Domains Scattering, Small Angle Tyrosine X-Ray Diffraction |
| Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Lepack A.E.; Werner C.T.; Stewart A.F.; Fulton S.L.; Zhong P.; Farrelly L.A.; Smith A.C.W.; Ramakrishnan A.; Lyu Y.; Bastle R.M.; Martin J.A.; Mitra S.; O'Connor R.M.; Wang Z.-J.; Molina H.; Turecki G.; Shen L.; Yan Z.; Calipari E.S.; Dietz D.M.; Kenny P.J.; Maze I.
收藏 | 浏览/下载：51/0 | 提交时间：2020/07/28
amidase dopamine histone H3 histone transamidase protein glutamine gamma glutamyltransferase 2 RNA unclassified drug brain cell chemical compound chemical reaction gene expression genetic analysis protein action potential amino acid substitution amino terminal sequence Article cocaine dependence controlled study dopamine release dopaminergic nerve cell dopaminergic transmission down regulation drug seeking behavior enzyme activity gene expression histone dopaminylation histone modification human human tissue hyperpolarization in vitro study motivation nerve cell plasticity nerve projection neuropathology nucleus accumbens priority journal protein expression protein function reward RNA sequence ventral tegmentum Rattus |
| Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者: Ebright R.Y.; Lee S.; Wittner B.S.; Niederhoffer K.L.; Nicholson B.T.; Bardia A.; Truesdell S.; Wiley D.F.; Wesley B.; Li S.; Mai A.; Aceto N.; Vincent-Jordan N.; Szabolcs A.; Chirn B.; Kreuzer J.; Comaills V.; Kalinich M.; Haas W.; Ting D.T.; Toner M.; Vasudevan S.; Haber D.A.; Maheswaran S.; Micalizzi D.S.
收藏 | 浏览/下载：56/0 | 提交时间：2020/07/28
CRISPR associated protein epidermal growth factor receptor 2 Ki 67 antigen ribosome protein ribosome RNA transcription factor E2F ribosome protein cancer cell gene expression genetic engineering protein RNA tumor animal experiment animal model animal tissue Article biogenesis bioluminescence breast cancer cell cycle progression cell cycle regulation cell proliferation circulating tumor cell controlled study enzyme activation epithelial mesenchymal transition gene expression profiling genetic transcription human human cell lung metastasis metastasis microfluidics mouse nonhuman overall survival phenotype priority journal progression free survival promoter region protein expression protein processing protein synthesis proteomics RNA sequence transcription regulation animal breast tumor cancer transplantation CRISPR Cas system female gene expression regulation genetics pathology sequence analysis tumor cell line tumor embolism Mus Animals Breast Neoplasms Cell Line, Tumor CRISPR-Cas Systems Female Gene Expression Regulation, Neoplastic Humans Mice Neoplasm Metastasis Neoplasm Transplantation Neoplastic Cells, Circulating Ribosomal Proteins Sequence Analysis, RNA |
| Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: He S.; Wu Z.; Tian Y.; Yu Z.; Yu J.; Wang X.; Li J.; Liu B.; Xu Y.
收藏 | 浏览/下载：38/0 | 提交时间：2020/07/28
actin related protein adenosine triphosphatase BRG1 BRM associated factor DNA multiprotein complex protein SWI retinoblastoma binding protein 2 SMARCC protein SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1 transcription factor transcription factor SNF unclassified drug cancer enzyme activity gene expression hydrolysis mutation protein alpha helix Article carboxy terminal sequence cell interaction cryoelectron microscopy disease association human malignant neoplasm molecular recognition mutation nucleosome priority journal protein function protein hydrolysis protein structure structure analysis Mammalia |
| TTC5 mediates autoregulation of tubulin via mRNA degradation 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者: Lin Z.; Gasic I.; Chandrasekaran V.; Peters N.; Shao S.; Mitchison T.J.; Hegde R.S.
收藏 | 浏览/下载：26/0 | 提交时间：2020/07/28
messenger RNA mutant protein polypeptide recombinant protein regulator protein tetratricopeptide protein 5 tubulin unclassified drug biodegradation chromosome peptide protein RNA amino terminal sequence animal cell Article autoregulation binding site chromosome segregation controlled study cryoelectron microscopy genetic code human human cell Leporidae mitosis molecular model nonhuman priority journal protein analysis protein binding protein interaction protein structure reticulocyte ribosome RNA degradation RNA translation tubulin gene |
| Regenerative potential of prostate luminal cells revealed by single-cell analysis 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者: Karthaus W.R.; Hofree M.; Choi D.; Linton E.L.; Turkekul M.; Bejnood A.; Carver B.; Gopalan A.; Abida W.; Laudone V.; Biton M.; Chaudhary O.; Xu T.; Masilionis I.; Manova K.; Mazutis L.; Pe’er D.; Regev A.; Sawyers C.L.
收藏 | 浏览/下载：229/0 | 提交时间：2020/07/28
androgen growth factor Nrg2 growth factor Rspo3 growth factor unclassified drug androgen binding protein antiandrogen ataxin 1 Atxn1 protein, mouse glycosylphosphatidylinositol anchored protein homeodomain protein nerve growth factor Nkx3-1 protein, mouse Nrg2 protein, mouse probasin Psca protein, mouse R-spondin3 protein, mouse thrombospondin transcription factor tumor antigen tumor protein androgen cancer cell gene expression RNA rodent ablation therapy animal cell animal tissue Article cell differentiation cell population cell regeneration cells by body anatomy controlled study gene gene expression human luminal cell male mesenchyme cell mouse nonhuman paracrine signaling priority journal prostate cell prostate tissue protein expression Psca gene RNA sequencing Sca1 gene single cell analysis animal genetics mesenchymal stem cell metabolism organ size organoid physiology prostate prostate tumor regeneration sequence analysis single cell analysis Mus Androgen Antagonists Androgen-Binding Protein Androgens Animals Antigens, Neoplasm Ataxin-1 Cell Differentiation Gene Expression GPI-Linked Proteins Homeodomain Proteins Humans Male Mesenchymal Stem Cells Mice Neoplasm Proteins Nerve Growth Factors Organ Size Organoids Prostate Prostatic Neoplasms Regeneration Sequence Analysis, RNA Single-Cell Analysis Thrombospondins Transcription Factors |
| A cell atlas of human thymic development defines T cell repertoire formation 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Park J.-E.; Botting R.A.; Conde C.D.; Popescu D.-M.; Lavaert M.; Kunz D.J.; Goh I.; Stephenson E.; Ragazzini R.; Tuck E.; Wilbrey-Clark A.; Roberts K.; Kedlian V.R.; Ferdinand J.R.; He X.; Webb S.; Maunder D.; Vandamme N.; Mahbubani K.T.; Polanski K.; Mamanova L.; Bolt L.; Crossland D.; De Rita F.; Fuller A.; Filby A.; Reynolds G.; Dixon D.; Saeb-Parsy K.; Lisgo S.; Henderson D.; Vento-Tormo R.; Bayraktar O.A.; Barker R.A.; Meyer K.B.; Saeys Y.; Bonfanti P.; Behjati S.; Clatworthy M.R.; Taghon T.; Haniffa M.; Teichmann S.A.
收藏 | 浏览/下载：69/0 | 提交时间：2020/07/28
T lymphocyte receptor cell component developmental biology differentiation genomics recombination RNA adaptive immunity Article CD4+ T lymphocyte CD8+ T lymphocyte cell fate cell maturation cell selection controlled study developmental stage gene gene expression gene expression profiling GNG4 gene human human cell human tissue lymphocyte differentiation priority journal protein expression regulatory T lymphocyte RNA sequencing sequence analysis T lymphocyte T lymphocyte activation thymic medulla thymocyte thymus XCL1 gene |
| Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Suomivuori C.-M.; Latorraca N.R.; Wingler L.M.; Eismann S.; King M.C.; Kleinhenz A.L.W.; Skiba M.A.; Staus D.P.; Kruse A.C.; Lefkowitz R.J.; Dror R.O.
收藏 | 浏览/下载：26/0 | 提交时间：2020/07/28
angiotensin 1 receptor beta arrestin 1 beta arrestin 2 G protein coupled receptor rhodopsin chemical binding design method ligand molecular analysis protein signaling allosterism Article carboxy terminal sequence conformational transition controlled study crystal structure human ligand binding molecular dynamics priority journal protein conformation signal transduction structural model |
| Pervasive functional translation of noncanonical human open reading frames 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Chen J.; Brunner A.-D.; Cogan J.Z.; Nuñez J.K.; Fields A.P.; Adamson B.; Itzhak D.N.; Li J.Y.; Mann M.; Leonetti M.D.; Weissman J.S.
收藏 | 浏览/下载：54/0 | 提交时间：2020/07/28
messenger RNA antigen cell component cell organelle chemical binding growth phenotype protein Quaternary RNA Article cell function cell growth cellular distribution clustered regularly interspaced short palindromic repeat gene sequence genetic screening HLA system human non-canonical base pairing open reading frame operon priority journal protein analysis protein binding protein function transcriptomics translation regulation Mammalia |
