气候变化领域集成服务门户(CCPortal): A cell atlas of human thymic development defines T cell repertoire formation

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DOI	10.1126/science.aay3224
	A cell atlas of human thymic development defines T cell repertoire formation
	Park J.-E.; Botting R.A.; Conde C.D.; Popescu D.-M.; Lavaert M.; Kunz D.J.; Goh I.; Stephenson E.; Ragazzini R.; Tuck E.; Wilbrey-Clark A.; Roberts K.; Kedlian V.R.; Ferdinand J.R.; He X.; Webb S.; Maunder D.; Vandamme N.; Mahbubani K.T.; Polanski K.; Mamanova L.; Bolt L.; Crossland D.; De Rita F.; Fuller A.; Filby A.; Reynolds G.; Dixon D.; Saeb-Parsy K.; Lisgo S.; Henderson D.; Vento-Tormo R.; Bayraktar O.A.; Barker R.A.; Meyer K.B.; Saeys Y.; Bonfanti P.; Behjati S.; Clatworthy M.R.; Taghon T.; Haniffa M.; Teichmann S.A.
发表日期	2020
ISSN	0036-8075
卷号	367 期号:6480
英文摘要	The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA sequencing to create a cell census of the human thymus across the life span and to reconstruct T cell differentiation trajectories and T cell receptor (TCR) recombination kinetics. Using this approach, we identified and located in situ CD8aa+ T cell populations, thymic fibroblast subtypes, and activated dendritic cell states. In addition, we reveal a bias in TCR recombination and selection, which is attributed to genomic position and the kinetics of lineage commitment. Taken together, our data provide a comprehensive atlas of the human thymus across the life span with new insights into human T cell development. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	T lymphocyte receptor cell component developmental biology differentiation genomics recombination RNA adaptive immunity Article CD4+ T lymphocyte CD8+ T lymphocyte cell fate cell maturation cell selection controlled study developmental stage gene gene expression gene expression profiling GNG4 gene human human cell human tissue lymphocyte differentiation priority journal protein expression regulatory T lymphocyte RNA sequencing sequence analysis T lymphocyte T lymphocyte activation thymic medulla thymocyte thymus XCL1 gene
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133698
推荐引用方式 GB/T 7714	Park J.-E.,Botting R.A.,Conde C.D.,et al. A cell atlas of human thymic development defines T cell repertoire formation[J]. Science,2020,367(6480).
APA	Park J.-E..,Botting R.A..,Conde C.D..,Popescu D.-M..,Lavaert M..,...&Teichmann S.A..(2020).A cell atlas of human thymic development defines T cell repertoire formation.,367(6480).
MLA	Park J.-E.,et al."A cell atlas of human thymic development defines T cell repertoire formation".367.6480(2020).