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A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity 期刊论文
, 2020, 卷号: 369, 期号: 6499
作者:  Meeske A.J.;  Jia N.;  Cassel A.K.;  Kozlova A.;  Liao J.;  Wiedmann M.;  Patel D.J.;  Marraffini L.A.
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/28
CRISPR associated protein  endonuclease  guide RNA  viral protein  virus RNA  bacteriophage  clustered regularly interspaced short palindromic repeat  CRISPR Cas system  DNA cleavage  genetics  Listeria  metabolism  RNA stability  virology  Bacteriophages  Clustered Regularly Interspaced Short Palindromic Repeats  CRISPR-Associated Proteins  CRISPR-Cas Systems  DNA Cleavage  Endonucleases  Listeria  RNA Stability  RNA, Guide  RNA, Viral  Viral Proteins  
Pervasive functional translation of noncanonical human open reading frames 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Chen J.;  Brunner A.-D.;  Cogan J.Z.;  Nuñez J.K.;  Fields A.P.;  Adamson B.;  Itzhak D.N.;  Li J.Y.;  Mann M.;  Leonetti M.D.;  Weissman J.S.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
messenger RNA  peptide  transcriptome  CRISPR Cas system  genetics  human  metabolism  open reading frame  operon  protein synthesis  ribosome  CRISPR-Cas Systems  Humans  Open Reading Frames  Operon  Peptides  Protein Biosynthesis  Ribosomes  RNA, Messenger  Transcriptome  
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Walton R.T.;  Christie K.A.;  Whittaker M.N.;  Kleinstiver B.P.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
adenine  adenosine  CRISPR associated endonuclease Cas9  cytosine  guanosine  SpG protein  SpRY nuclease  thymine  unclassified drug  Cas9 endonuclease Streptococcus pyogenes  bacterium  enzyme activity  genetic engineering  genetic variation  genome  Article  CRISPR-CAS9 system  DNA sequence  enzyme activity  gene editing  gene targeting  genetic variability  human  mutagenesis  nonhuman  priority journal  protein engineering  protein motif  protein structure  protospacer adjacent motif  Streptococcus pyogenes  chemistry  CRISPR Cas system  enzyme specificity  gene editing  gene targeting  genetic predisposition  genetics  HEK293 cell line  procedures  protein domain  Streptococcus pyogenes  CRISPR-Associated Protein 9  CRISPR-Cas Systems  Gene Editing  Gene Targeting  Genetic Predisposition to Disease  HEK293 Cells  Humans  Mutagenesis  Protein Domains  Substrate Specificity  
Modulating microbiome metabolites in vivo 期刊论文
, 2020, 卷号: 369, 期号: 6500
作者:  Guo C.-J.
收藏  |  浏览/下载：21/0  |  提交时间：2020/07/28
Clostridium  CRISPR Cas system  genetics  human  intestine flora  metabolism  Clostridium  CRISPR-Cas Systems  Gastrointestinal Microbiome  Host Microbial Interactions  Humans  
Very fast CRISPR on demand 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Liu Y.;  Zou R.S.;  He S.;  Nihongaki Y.;  Li X.;  Razavi S.;  Wu B.;  Ha T.
收藏  |  浏览/下载：21/0  |  提交时间：2020/07/28
Cas9 endonuclease Streptococcus pyogenes  double strand break repair protein MRE11  H2AX protein, human  histone  MRE11 protein, human  CRISPR Cas system  DNA cleavage  DNA repair  double stranded DNA break  fluorescence imaging  gene editing  genetics  HEK293 cell line  human  light  metabolism  phosphorylation  procedures  radiation response  single cell analysis  CRISPR-Associated Protein 9  CRISPR-Cas Systems  DNA Breaks, Double-Stranded  DNA Cleavage  DNA Repair  Gene Editing  HEK293 Cells  Histones  Humans  Light  MRE11 Homologue Protein  Optical Imaging  Phosphorylation  Single-Cell Analysis  
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Ebright R.Y.;  Lee S.;  Wittner B.S.;  Niederhoffer K.L.;  Nicholson B.T.;  Bardia A.;  Truesdell S.;  Wiley D.F.;  Wesley B.;  Li S.;  Mai A.;  Aceto N.;  Vincent-Jordan N.;  Szabolcs A.;  Chirn B.;  Kreuzer J.;  Comaills V.;  Kalinich M.;  Haas W.;  Ting D.T.;  Toner M.;  Vasudevan S.;  Haber D.A.;  Maheswaran S.;  Micalizzi D.S.
收藏  |  浏览/下载：54/0  |  提交时间：2020/07/28
CRISPR associated protein  epidermal growth factor receptor 2  Ki 67 antigen  ribosome protein  ribosome RNA  transcription factor E2F  ribosome protein  cancer  cell  gene expression  genetic engineering  protein  RNA  tumor  animal experiment  animal model  animal tissue  Article  biogenesis  bioluminescence  breast cancer  cell cycle progression  cell cycle regulation  cell proliferation  circulating tumor cell  controlled study  enzyme activation  epithelial mesenchymal transition  gene expression profiling  genetic transcription  human  human cell  lung metastasis  metastasis  microfluidics  mouse  nonhuman  overall survival  phenotype  priority journal  progression free survival  promoter region  protein expression  protein processing  protein synthesis  proteomics  RNA sequence  transcription regulation  animal  breast tumor  cancer transplantation  CRISPR Cas system  female  gene expression regulation  genetics  pathology  sequence analysis  tumor cell line  tumor embolism  Mus  Animals  Breast Neoplasms  Cell Line, Tumor  CRISPR-Cas Systems  Female  Gene Expression Regulation, Neoplastic  Humans  Mice  Neoplasm Metastasis  Neoplasm Transplantation  Neoplastic Cells, Circulating  Ribosomal Proteins  Sequence Analysis, RNA  
CRISPR-engineered T cells in patients with refractory cancer 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:  Stadtmauer E.A.;  Fraietta J.A.;  Davis M.M.;  Cohen A.D.;  Weber K.L.;  Lancaster E.;  Mangan P.A.;  Kulikovskaya I.;  Gupta M.;  Chen F.;  Tian L.;  Gonzalez V.E.;  Xu J.;  Jung I.-Y.;  Joseph Melenhorst J.;  Plesa G.;  Shea J.;  Matlawski T.;  Cervini A.;  Gaymon A.L.;  Desjardins S.;  Lamontagne A.;  Salas-Mckee J.;  Fesnak A.;  Siegel D.L.;  Levine B.L.;  Jadlowsky J.K.;  Young R.M.;  Chew A.;  Hwang W.-T.;  Hexner E.O.;  Carreno B.M.;  Nobles C.L.;  Bushman F.D.;  Parker K.R.;  Qi Y.;  Satpathy A.T.;  Chang H.Y.;  Zhao Y.;  Lacey S.F.;  June C.H.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
heterodimer  programmed death 1 receptor  T lymphocyte receptor alpha chain  T lymphocyte receptor beta chain  cancer  cell  gene  gene expression  genetic engineering  immunity  protein  adult  aged  Article  cancer patient  cell engineering  chromosome translocation  clinical article  clustered regularly interspaced short palindromic repeat  controlled study  CRISPR-CAS9 system  feasibility study  female  gene editing  gene expression  gene frequency  gene locus  genetic code  human  human cell  male  middle aged  myeloma  PDCD1 gene  phase 1 clinical trial  priority journal  sarcoma  T lymphocyte  TRAC gene  TRBC gene  tumor immunity  
MRNA destabilization by BTG1 and BTG2 maintains T cell quiescence 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Hwang S.S.;  Lim J.;  Yu Z.;  Kong P.;  Sefik E.;  Xu H.;  Harman C.C.D.;  Kim L.K.;  Lee G.R.;  Li H.-B.;  Flavell R.A.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
CD69 antigen  chemokine receptor CCR7  epidermal growth factor receptor 2  Hermes antigen  interleukin 2 receptor alpha  interleukin 2 receptor gamma  interleukin 7 receptor  kruppel like factor 2  messenger RNA  polyadenylic acid  T lymphocyte receptor  transcription factor FKHR  transcriptome  biodegradation  cell component  RNA  adenylation  Article  BTG1 gene  BTG2 gene  Ccr7 gene  CD4+ T lymphocyte  CD8+ T lymphocyte  cell differentiation  cell expansion  cell maturation  cell migration  cell proliferation  cell size  cell specificity  cell survival  controlled study  CRISPR-CAS9 system  flow cytometry  gene  gene control  gene expression  gene function  gene identification  immunoprecipitation  in vitro study  in vivo study  memory T lymphocyte  nonhuman  phylogenetic tree  priority journal  RNA degradation  RNA sequencing  S1pr1 gene  Sell gene  spleen  T lymphocyte  T lymphocyte activation  tail length (comet assay)  thymus  upregulation  
Hope for hematological diseases 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Wilkinson A.C.
收藏  |  浏览/下载：40/0  |  提交时间：2020/07/28
fibronectin  polyvinyl alcohol  serum albumin  stem cell factor  thrombopoietin  blood  disease incidence  disease treatment  laboratory method  medicine  public health  Article  cell differentiation  cell self-renewal  chemotherapy  CRISPR-CAS9 system  ex vivo study  gene editing  gene therapy  genotoxicity  graft versus host reaction  hematologic disease  hematopoiesis  hematopoietic stem cell transplantation  human  morbidity  mortality  multipotent stem cell  nonhuman  priority journal  radiotherapy  stem cell culture  stem cell expansion  
Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells 期刊论文
, 2020, 卷号: 368, 期号: 6493
作者:  Bálint Š.;  Müller S.;  Fischer R.;  Kessler B.M.;  Harkiolaki M.;  Valitutti S.;  Dustin M.L.
收藏  |  浏览/下载：45/0  |  提交时间：2020/07/28
cancer  cell  identification method  molecular analysis  reconstruction  granzyme  multiprotein complex  perforin  thrombospondin 1  CRISPR Cas system  cytotoxic T lymphocyte  cytotoxicity  exocytosis  gene editing  genetics  human  K-562 cell line  metabolism  x-ray tomography  CRISPR-Cas Systems  Cytotoxicity, Immunologic  Exocytosis  Gene Editing  Granzymes  Humans  K562 Cells  Multiprotein Complexes  Perforin  T-Lymphocytes, Cytotoxic  Thrombospondin 1  Tomography, X-Ray