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Changes in contact patterns shape the dynamics of the COVID-19 outbreak in China 期刊论文
, 2020, 卷号: 368, 期号: 6498
作者:  Zhang J.;  Litvinova M.;  Liang Y.;  Wang Y.;  Wang W.;  Zhao S.;  Wu Q.;  Merler S.;  Viboud C.;  Vespignani A.;  Ajelli M.;  Yu H.
收藏  |  浏览/下载：31/0  |  提交时间：2020/07/28
adolescent  adult  age  aged  behavior  Betacoronavirus  child  China  communicable disease control  contact examination  Coronavirus infection  disease predisposition  epidemic  female  human  infant  male  middle aged  pandemic  preschool child  school  theoretical model  virus pneumonia  workplace  young adult  Adolescent  Adult  Age Factors  Aged  Behavior  Betacoronavirus  Child  Child, Preschool  China  Communicable Disease Control  Contact Tracing  Coronavirus Infections  Disease Outbreaks  Disease Susceptibility  Female  Humans  Infant  Male  Middle Aged  Models, Theoretical  Pandemics  Pneumonia, Viral  Schools  Workplace  Young Adult  
Rigorous wildlife disease surveillance 期刊论文
, 2020, 卷号: 369, 期号: 6500
作者:  Watsa M.;  Wildlife Disease Surveillance Focus Group
收藏  |  浏览/下载：235/0  |  提交时间：2020/07/28
animal  bat  Betacoronavirus  biosurveillance  communicable disease  Coronavirus infection  global health  human  pandemic  virology  virus pneumonia  zoonosis  Animals  Betacoronavirus  Biosurveillance  Chiroptera  Communicable Diseases, Emerging  Coronavirus Infections  Global Health  Humans  Pandemics  Pneumonia, Viral  Zoonoses  
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载：45/0  |  提交时间：2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载：51/0  |  提交时间：2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Effective containment explains subexponential growth in recent confirmed COVID-19 cases in China 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Maier B.F.;  Brockmann D.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
disease control  disease prevalence  epidemic  health geography  public health  quarantine  symptom  viral disease  China  Coronavirus  basic reproduction number  behavior  Betacoronavirus  China  communicable disease control  contact examination  Coronavirus infection  disease predisposition  epidemic  human  pandemic  quarantine  statistical model  virus pneumonia  Basic Reproduction Number  Behavior  Betacoronavirus  China  Communicable Disease Control  Contact Tracing  Coronavirus Infections  Disease Outbreaks  Disease Susceptibility  Humans  Models, Statistical  Pandemics  Pneumonia, Viral  Quarantine  
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir 期刊论文
, 2020, 卷号: 368, 期号: 6498
作者:  Yin W.;  Mao C.;  Luan X.;  Shen D.-D.;  Shen Q.;  Su H.;  Wang X.;  Zhou F.;  Zhao W.;  Gao M.;  Chang S.;  Xie Y.-C.;  Tian G.;  Jiang H.-W.;  Tao S.-C.;  Shen J.;  Jiang Y.;  Jiang H.;  Xu Y.;  Zhang S.;  Zhang Y.;  Xu H.E.
收藏  |  浏览/下载：230/0  |  提交时间：2020/07/28
adenosine phosphate  alanine  antivirus agent  enzyme inhibitor  multiprotein complex  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  virus RNA  Betacoronavirus  chemistry  cryoelectron microscopy  drug effect  enzyme active site  enzymology  metabolism  molecular model  physiology  protein conformation  virus replication  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Enzyme Inhibitors  Models, Molecular  Multiprotein Complexes  Protein Conformation  RNA Replicase  RNA, Viral  Viral Nonstructural Proteins  Virus Replication  
Reducing transmission of SARS-CoV-2 期刊论文
, 2020, 卷号: 368, 期号: 6498
作者:  Prather K.A.;  Wang C.C.;  Schooley R.T.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
asymptomatic infection  Betacoronavirus  breathing  communicable disease control  Coronavirus infection  coughing  human  mask  microbiology  pandemic  physiology  respiratory function  sneezing  speech  time factor  virology  virus pneumonia  Air Microbiology  Asymptomatic Infections  Betacoronavirus  Communicable Disease Control  Coronavirus Infections  Cough  Humans  Masks  Pandemics  Pneumonia, Viral  Respiration  Respiratory Physiological Phenomena  Sneezing  Speech  Time Factors  
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Yuan M.;  Wu N.C.;  Zhu X.;  Lee C.-C.D.;  So R.T.Y.;  Lv H.;  Mok C.K.P.;  Wilson I.A.
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  epitope  neutralizing antibody  virus hemagglutinin  virus spike protein  angiotensin converting enzyme 2  coronavirus receptors  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  neutralizing antibody  spike glycoprotein, SARS-CoV  spike protein, SARS-CoV-2  virus antibody  virus antigen  virus receptor  antibody  antigen  chemical binding  crystal structure  protein  respiratory disease  viral disease  virus  amino terminal sequence  antibody isolation  antigen binding  antigenicity  Article  binding affinity  binding site  conservation biology  controlled study  coronavirus disease 2019  cross reaction  cryoelectron microscopy  crystal structure  enzyme linked immunosorbent assay  epidemic  glycosylation  human  hydrophobicity  immune response  in vitro study  in vivo study  light chain  nonhuman  priority journal  protein conformation  protein domain  protein interaction  protein localization  protein structure  protein targeting  receptor binding  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  antibody affinity  Betacoronavirus  binding site  chemistry  immunology  metabolism  molecular model  SARS coronavirus  X ray crystallography  Coronavirus  SARS coronavirus  Amino Acid Sequence  Antibodies, Neutralizing  Antibodies, Viral  Antibody Affinity  Antigens, Viral  Betacoronavirus  Binding Sites  Cross Reactions  Crystallography, X-Ray  Epitopes  Models, Molecular  Peptidyl-Dipeptidase A  Protein Conformation  Protein Domains  Protein Interaction Domains and Motifs  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus  
Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Ferretti L.;  Wymant C.;  Kendall M.;  Zhao L.;  Nurtay A.;  Abeler-Dörner L.;  Parker M.;  Bonsall D.;  Fraser C.
收藏  |  浏览/下载：32/0  |  提交时间：2020/07/28
disease control  epidemic  memory  parasite transmission  viral disease  Article  asymptomatic disease  China  contact examination  coronavirus disease 2019  disease control  disease transmission  health care system  human  incubation time  mathematical model  mobile application  mortality rate  priority journal  quarantine  rating scale  Severe acute respiratory syndrome coronavirus 2  virus transmission  algorithm  basic reproduction number  Betacoronavirus  contact examination  Coronavirus infection  epidemic  ethics  infection control  mobile application  mobile phone  pandemic  probability  procedures  theoretical model  time factor  virus pneumonia  Coronavirus  SARS coronavirus  Algorithms  Asymptomatic Diseases  Basic Reproduction Number  Betacoronavirus  Cell Phone  China  Contact Tracing  Coronavirus Infections  Epidemics  Humans  Infection Control  Mobile Applications  Models, Theoretical  Pandemics  Pneumonia, Viral  Probability  Quarantine  Time Factors  
Rapid implementation of mobile technology for real-time epidemiology of COVID-19 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Drew D.A.;  Nguyen L.H.;  Steves C.J.;  Menni C.;  Freydin M.;  Varsavsky T.;  Sudre C.H.;  Jorge Cardoso M.;  Ourselin S.;  Wolf J.;  Spector T.D.;  Chan A.T.;  COPE Consortium
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/28
data assimilation  epidemiology  public health  real time  risk factor  severe acute respiratory syndrome  viral disease  United Kingdom  United States  Coronavirus  SARS coronavirus  Betacoronavirus  Coronavirus infection  devices  global health  human  information processing  international cooperation  mobile application  pandemic  procedures  theoretical model  United Kingdom  United States  virus pneumonia  Betacoronavirus  Big Data  Coronavirus Infections  Data Collection  Global Health  Humans  International Cooperation  Mobile Applications  Models, Theoretical  Pandemics  Pneumonia, Viral  United Kingdom  United States