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A general method to synthesize and sinter bulk ceramics in seconds 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:  Wang C.;  Ping W.;  Bai Q.;  Cui H.;  Hensleigh R.;  Wang R.;  Brozena A.H.;  Xu Z.;  Dai J.;  Pei Y.;  Zheng C.;  Pastel G.;  Gao J.;  Wang X.;  Wang H.;  Zhao J.-C.;  Yang B.;  Zheng X.;  Luo J.;  Mo Y.;  Dunn B.;  Hu L.
收藏  |  浏览/下载:26/0  |  提交时间:2020/07/28
electrolyte  ceramics  chemical composition  computer system  electrolyte  heating  mechanical property  radiative transfer  sinter  volatile element  Article  ceramics  chemical structure  high temperature procedures  high throughput screening  materials testing  priority journal  radiation  solid state  synthesis  ultrafast high temperature sintering  
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载:44/0  |  提交时间:2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Vertebrate diapause preserves organisms long term through Polycomb complex members 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Hu C.-K.;  Wang W.;  Brind'Amour J.;  Singh P.P.;  Adam Reeves G.;  Lorincz M.C.;  Alvarado A.S.;  Brunet A.
收藏  |  浏览/下载:33/0  |  提交时间:2020/07/28
polycomb group protein  protein CBX7  transcriptome  unclassified drug  diapause  gene expression  metabolism  muscle  vertebrate  Article  chromatin  complex formation  developmental gene  diapause  down regulation  embryo development  fertility  gene  gene expression regulation  gene repression  genetic regulation  growth rate  lifespan  lipid metabolism  metabolism  muscle atrophy  muscle gene  neuromuscular junction  nonhuman  priority journal  protein function  tissue preservation  upregulation  vertebrate  Cyprinodontoidei  Nothobranchius furzeri  Vertebrata  
Structural evidence for a dynamic metallocofactor during N2 reduction by Mo-nitrogenase 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Kang W.;  Lee C.C.;  Jasniewski A.J.;  Ribbe M.W.;  Hu Y.
收藏  |  浏览/下载:42/0  |  提交时间:2020/07/28
ammonia  catalysis  crystal structure  enzyme activity  ligand  physiological response  sulfur  ligand  molybdenum iron protein  nitrogen  sulfur  Azotobacter vinelandii  biocatalysis  chemistry  enzymology  oxidation reduction reaction  protein multimerization  X ray crystallography  Azotobacter vinelandii  Biocatalysis  Crystallography, X-Ray  Ligands  Molybdoferredoxin  Nitrogen  Oxidation-Reduction  Protein Multimerization  Sulfur