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By the end of the century, climate projections for southern Europe exhibit an enhanced near-surface summer warming in response to greenhouse gas emissions, which is known as the Mediterranean amplification. Possible causes for this amplified warming signal include a poleward Hadley cell expansion as well as tropospheric lapse-rate changes. In this work, regional climate model (RCM) simulations driven by three different global climate models (GCMs) are performed, representing the RCP8.5 emission scenario. For every downscaled GCM, the climate change signal over Europe is separated into five contributions by modifying the lateral boundary conditions of the RCM. This simulation strategy is related to the pseudo-global warming method. The results show that a poleward expansion of the Hadley cell is of minor importance for the Mediterranean amplification. During summer, the simulated Hadley circulation is weak, and projections show no distinct expansion in the European sector. The north-south contrast in lapse-rate changes is suggested as the most important factor causing the Mediterranean amplification. Lapse-rate changes are projected throughout Europe, but are weaker over the Mediterranean than over northern Europe (around 0.15 vs 0.3 K km(-1) by the end of the century). The weaker lapse-rate changes result in a strong near-surface summer warming over the Mediterranean, since the upper-tropospheric warming is of similar magnitude throughout Europe. The differing lapse-rate changes can be understood as a thermodynamic response to lower-tropospheric humidity contrasts.