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The Yiluo region in the middle Yellow River has been a core area of archaeological inquiry for understanding the origins of the first dynastic states in China. In order to investigate the social changes on a regional scale, a systematic full-coverage regional survey project was carried out from 1997 to 2018, covering an area of 1183 km(2) in the Yiluo region. This paper analyzes the settlement patterns of 451 sites of the Neolithic and Bronze Ages (ca. 6000-200 cal. BC), providing the most comprehensive pictures yet, of the spatial and temporal relationships of settlement distribution during a nearly 6000-year time span. The paper demonstrates a developmental trajectory from a landscape dotted with scattered, small Neolithic villages to a highly centralized dynastic heartland in early Chinese civilization. The evolutionary pathways were not straightforward, but were characterized by episodic fluctuations in population density, and the rise and fall of complex societies. Holocene climatic fluctuations may have played significant roles affecting human activities, but it is the human responses to external challenges in various ways that ultimately determined the trajectories of social evolution.