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| DOI | 10.1021/acschembio.7b00262 |
| Biosynthetic Insights into Linaridin Natural Products from Genome Mining and Precursor Peptide Mutagenesis | |
| Mo T.; Liu W.-Q.; Ji W.; Zhao J.; Chen T.; Ding W.; Yu S.; Zhang Q. | |
| 发表日期 | 2017 |
| ISSN | 15548929 |
| 卷号 | 12期号:6 |
| 英文摘要 | Linaridin is a small class of peptide natural products belonging to the ribosomally synthesized and post-translationally modified peptides (RiPPs) superfamily. By an extensive genome-wide survey of linaridin biosynthetic genes, we show that this class of natural products is widespread in nature and possesses vast structural diversity. The linaridin precursor peptides are relatively conserved in the N-termini but have diverse sequences in the core region, which appear to have coevolved with the biosynthetic enzymes. Using the prototypic linaridin cypemycin as a model, we have explored the structure-activity relationships involved in precursor peptide maturation and generated a diverse set of novel cypemycin variants, among which the T2S variant exhibits enhanced activity against Micrococcus luteus. Our results reveal valuable insights into linaridin biosynthesis and highlight the potential to explore this class of natural products by genome mining and by biosynthetic engineering studies. © 2017 American Chemical Society. |
| URL | https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85020547088&doi=10.1021%2facschembio.7b00262&partnerID=40&md5=b622ed91173f652d687fa9896f7e9da1 |
| 语种 | 英语 |
| scopus关键词 | antibiotic agent; cypemycin A; cypemycin H; natural product; signal peptide; unclassified drug; bacteriocin; biological product; cypemycin; peptide; amino terminal sequence; Article; carboxy terminal sequence; drug synthesis; gene cluster; genome; heterologous expression; hydrophobicity; Micrococcus luteus; minimum inhibitory concentration; nonhuman; phylogenetic tree; priority journal; site directed mutagenesis; Streptomyces coelicolor; structure activity relation; bacterial genome; biosynthesis; data mining; drug effects; genetics; multigene family; mutagenesis; Bacteriocins; Biological Products; Biosynthetic Pathways; Data Mining; Genome, Bacterial; Micrococcus luteus; Multigene Family; Mutagenesis; Peptides; Structure-Activity Relationship |
| 来源期刊 | ACS Chemical Biology
 |
| 来源机构 | 中国科学院西北生态环境资源研究院 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/77140 |
| 推荐引用方式 GB/T 7714 | Mo T.； Liu W.-Q.； Ji W.； Zhao J.； Chen T.； Ding W.； Yu S.； Zhang Q.. Biosynthetic Insights into Linaridin Natural Products from Genome Mining and Precursor Peptide Mutagenesis[J]. 中国科学院西北生态环境资源研究院,2017,12(6). |
| APA | Mo T.； Liu W.-Q.； Ji W.； Zhao J.； Chen T.； Ding W.； Yu S.； Zhang Q..(2017).Biosynthetic Insights into Linaridin Natural Products from Genome Mining and Precursor Peptide Mutagenesis.ACS Chemical Biology,12(6). |
| MLA | Mo T.； Liu W.-Q.； Ji W.； Zhao J.； Chen T.； Ding W.； Yu S.； Zhang Q.."Biosynthetic Insights into Linaridin Natural Products from Genome Mining and Precursor Peptide Mutagenesis".ACS Chemical Biology 12.6(2017). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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