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| Climate change and cardiovascular disease susceptibility in an animal model-Resubmission | |
| 项目编号 | 1R21ES026731-01A1 |
| CHEN, LUNG-CHI | |
| 项目主持机构 | NEW YORK UNIVERSITY SCHOOL OF MEDICINE |
| 开始日期 | 2017-02-01 |
| 结束日期 | 2019-01-31 |
| 英文摘要 | Summary/Abstract It is anticipated that climate change with increasing global surface temperature will be accompanied with increases in the frequency, intensity, and duration of extreme weather. Climate change and air pollution are intrinsically connected and the synergistic effects of air pollution and high temperature need to be taken into account to set up adequate public health policies and actions to face the future changes in air pollution and climate. In this study, we will test the hypothesis that diet induced obesity could enhance the interactive effects of air pollution and extreme weather. Our approach is to study the adverse cardiometabolic effects of concentrated ambient PM (CAPs, by inhalation, 6hr/d, 7d/w, for up to 6 months) with or without heat stress in mice (both male and female) on normal or high fat chow. Body core temperature as well as heart rate and heart rate variability will be monitored continuously thoughout the experiments using telemetry. Fasting blood glucose level will be measured weekly. On week 7, 15, and 23 of CAPs exposure, heat stress will be applied (6 hr/d for 7 days) to simulate a summer heat wave. In addition to continuous telemetry data, serial endpoints (24hr after the last heat stress exposure) of lung lavage, cardiac (ultrasound) and vascular function (myograph), glucose/insulin tolerance, inflammatory markers (e.g. cytokines and stress proteins) will be performed. Transcriptome analysis using RNA-seq in selected tissues (lung, heart, brain [hypothalamus], liver, spleen, fat tissues, and muscle) will also be measured. We will identify the biomarkers most closely linked to the adverse effects. After completion of these in vivo bioassays and the in silico analyses, gene function pathways that are relevant to the health effects of human exposed to air pollution and heat stress will be identified. |
| 英文关键词 | Work;Weather;Urbanization;Ultrasonography;transcriptome sequencing;transcriptome;Transcript;Toxic effect;Tissues;Testing;Temperature;Telemetry;Technology;System;Sympathetic Nervous System;Surface;stress protein;Stress;Spleen;Source;Serum Markers;Rosa;Risk Factors;response;Reporting;Public Health;prevent;Predisposition;Population Growth;Pollution;pollutant;Physiological;Persons;Peripheral;Pathway interactions;Pathway Analysis;Particulate Matter;Outcome;Obesity;novel strategies;next generation sequencing;Natural Resources;Muscle;Mus;mouse model;mortality;Morbidity - disease rate;Monitor;Metabolism;Mediating;Measures;male;Lung diseases;Lung;Liver;Link;Lead;land use;Ischemia;insulin tolerance;inflammatory marker;Inflammation;in vivo Bioassay;hypothalamic-pituitary-adrenal axis;Hypothalamic structure;human subject;Human;High temperature of physical object;High Fat Diet;Heat Waves;Heat Stress Disorders;Heat shock proteins;heart rate variability;Heart Rate;Heart;Health Policy;Health;greenhouse gases;Glucose;Global Change;Genes;gene function;Future;Functional disorder;Frequencies;Fossil Fuels;Female;Fatty acid glycerol esters;fasting blood glucose level;Face;Exposure to;experimental study;Elderly;Disease susceptibility;Diet;Data;cytokine;Computer Simulation;climate change;Climate;Cerebrovascular Disorders;Cardiovascular system;Cardiovascular Diseases;Cardiac;Carbon Dioxide;Bronchoalveolar Lavage;Breathing;Brain;Blood Vessels;Blood Pressure;Biological Markers;Animal Model;ambient particle;Air Pollution;Air Pollutants;Adverse effects;Address |
| 学科分类 | 14 - 医学科学 |
| 资助机构 | US-NIH |
| 项目经费 | 254250 |
| 项目类型 | Non-SBIR/STTR RPGs |
| 国家 | US |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/69524 |
| 推荐引用方式 GB/T 7714 | CHEN, LUNG-CHI.Climate change and cardiovascular disease susceptibility in an animal model-Resubmission.2017. |
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