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DOI | 10.1016/j.tox.2015.07.007 |
Conceptual model for assessing criteria air pollutants in a multipollutant context: A modified adverse outcome pathway approach | |
Buckley, Barbara1; Farraj, Aimen2 | |
发表日期 | 2015-09-01 |
ISSN | 0300-483X |
卷号 | 335页码:85-94 |
英文摘要 | Air pollution consists of a complex mixture of particulate and gaseous components. Individual criteria and other hazardous air pollutants have been linked to adverse respiratory and cardiovascular health outcomes. However, assessing risk of air pollutant mixtures is difficult since components are present in different combinations and concentrations in ambient air. Recent mechanistic studies have limited utility because of the inability to link measured changes to adverse outcomes that are relevant to risk assessment. New approaches are needed to address this challenge. The purpose of this manuscript is to describe a conceptual model, based on the adverse outcome pathway approach, which connects initiating events at the cellular and molecular level to population-wide impacts. This may facilitate hazard assessment of air pollution mixtures. In the case reports presented here, airway hyperresponsiveness and endothelial dysfunction are measurable endpoints that serve to integrate the effects of individual criteria air pollutants found in inhaled mixtures. This approach incorporates information from experimental and observational studies into a sequential series of higher order effects. The proposed model has the potential to facilitate multipollutant risk assessment by providing a framework that can be used to converge the effects of air pollutants in light of common underlying mechanisms. This approach may provide a ready-to-use tool to facilitate evaluation of health effects resulting from exposure to air pollution mixtures. Published by Elsevier Ireland Ltd. |
英文关键词 | Air pollution;Criteria pollutants;Multipollutant;Adverse outcome pathway |
语种 | 英语 |
WOS记录号 | WOS:000360517600011 |
来源期刊 | TOXICOLOGY
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/62251 |
作者单位 | 1.US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA; 2.US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA |
推荐引用方式 GB/T 7714 | Buckley, Barbara,Farraj, Aimen. Conceptual model for assessing criteria air pollutants in a multipollutant context: A modified adverse outcome pathway approach[J]. 美国环保署,2015,335:85-94. |
APA | Buckley, Barbara,&Farraj, Aimen.(2015).Conceptual model for assessing criteria air pollutants in a multipollutant context: A modified adverse outcome pathway approach.TOXICOLOGY,335,85-94. |
MLA | Buckley, Barbara,et al."Conceptual model for assessing criteria air pollutants in a multipollutant context: A modified adverse outcome pathway approach".TOXICOLOGY 335(2015):85-94. |
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