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DOI | 10.1088/1361-6498/aad348 |
Implications of recent epidemiologic studies for the linear nonthreshold model and radiation protection | |
Shore, R. E.1,2; Beck, H. L.3; Boice, J. D.4,5; Caffrey, E. A.6; Davis, S.7; Grogan, H. A.8; Mettler, F. A.9; Preston, R. J.10; Till, J. E.11; Wakeford, R.12; Walsh, L.13; Dauer, L. T.14 | |
发表日期 | 2018-09-01 |
ISSN | 0952-4746 |
卷号 | 38期号:3页码:1217-1233 |
英文摘要 | The recently published NCRP Commentary No. 27 evaluated the new information from epidemiologic studies as to their degree of support for applying the linear nonthreshold (LNT) model of carcinogenic effects for radiation protection purposes (NCRP 2018 Implications of Recent Epidemiologic Studies for the Linear Nonthreshold Model and Radiation Protection, Commentary No. 27 (Bethesda, MD: National Council on Radiation Protection and Measurements)). The aim was to determine whether recent epidemiologic studies of low-LET radiation, particularly those at low doses and/or low dose rates (LD/LDR), broadly support the LNT model of carcinogenic risk or, on the contrary, demonstrate sufficient evidence that the LNT model is inappropriate for the purposes of radiation protection. An updated review was needed because a considerable number of reports of radiation epidemiologic studies based on new or updated data have been published since other major reviews were conducted by national and international scientific committees. The Commentary provides a critical review of the LD/LDR studies that are most directly applicable to current occupational, environmental and medical radiation exposure circumstances. This Memorandum summarises several of the more important LD/LDR studies that incorporate radiation dose responses for solid cancer and leukemia that were reviewed in Commentary No. 27. In addition, an overview is provided of radiation studies of breast and thyroid cancers, and cancer after childhood exposures. Non-cancers are briefly touched upon such as ischemic heart disease, cataracts, and heritable genetic effects. To assess the applicability and utility of the LNT model for radiation protection, the Commentary evaluated 29 epidemiologic studies or groups of studies, primarily of total solid cancer, in terms of strengths and weaknesses in their epidemiologic methods, dosimetry approaches, and statistical modelling, and the degree to which they supported a LNT model for continued use in radiation protection. Recommendations for how to make epidemiologic radiation studies more informative are outlined. The NCRP Committee recognises that the risks from LD/LDR exposures are small and uncertain. The Committee judged that the available epidemiologic data were broadly supportive of the LNT model and that at this time no alternative dose-response relationship appears more pragmatic or prudent for radiation protection purposes. |
英文关键词 | linear nonthreshold model;low dose-rate epidemiologic studies;solid cancer;leukaemia |
语种 | 英语 |
WOS记录号 | WOS:000443309100006 |
来源期刊 | JOURNAL OF RADIOLOGICAL PROTECTION
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/61863 |
作者单位 | 1.NYU, Sch Med, New York, NY 10003 USA; 2.Radiat Effects Res Fdn, Hiroshima, Japan; 3.US DOE, New York, NY USA; 4.Natl Council Radiat Protect & Measurements, Bethesda, MD USA; 5.Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA; 6.Radian Sci, Huntsville, AL USA; 7.Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA; 8.Cascade Sci, Bend, OR USA; 9.Univ New Mexico, Albuquerque, NM 87131 USA; 10.US EPA, Res Triangle Pk, NC 27711 USA; 11.Risk Assessment Corp, Neeses, SC USA; 12.Univ Manchester, Manchester, Lancs, England; 13.Univ Zurich, Zurich, Switzerland; 14.Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA |
推荐引用方式 GB/T 7714 | Shore, R. E.,Beck, H. L.,Boice, J. D.,et al. Implications of recent epidemiologic studies for the linear nonthreshold model and radiation protection[J]. 美国环保署,2018,38(3):1217-1233. |
APA | Shore, R. E..,Beck, H. L..,Boice, J. D..,Caffrey, E. A..,Davis, S..,...&Dauer, L. T..(2018).Implications of recent epidemiologic studies for the linear nonthreshold model and radiation protection.JOURNAL OF RADIOLOGICAL PROTECTION,38(3),1217-1233. |
MLA | Shore, R. E.,et al."Implications of recent epidemiologic studies for the linear nonthreshold model and radiation protection".JOURNAL OF RADIOLOGICAL PROTECTION 38.3(2018):1217-1233. |
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