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DOI | 10.1177/1091581815576551 |
Systems Toxicology: The Future of Risk Assessment | |
Sauer, John Michael1; Hartung, Thomas2; Leist, Marcel3; Knudsen, Thomas B.4; Hoeng, Julia5; Hayes, A. Wallace6,7 | |
发表日期 | 2015-07-01 |
ISSN | 1091-5818 |
卷号 | 34期号:4页码:346-348 |
英文摘要 | Risk assessment, in the context of public health, is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. With increasing public health concern regarding the potential risks associated with chemical exposure, there is a need for more predictive and accurate approaches to risk assessment. Developing such an approach requires a mechanistic understanding of the process by which xenobiotic substances perturb biological systems and lead to toxicity. Supplementing the shortfalls of traditional risk assessment with mechanistic biological data has been widely discussed but not routinely implemented in the evaluation of chemical exposure. These mechanistic approaches to risk assessment have been generally referred to as systems toxicology. This Symposium Overview article summarizes 4 talks presented at the 35th Annual Meeting of the American College of Toxicology. |
英文关键词 | systems toxicology;risk assessment |
语种 | 英语 |
WOS记录号 | WOS:000359401300007 |
来源期刊 | INTERNATIONAL JOURNAL OF TOXICOLOGY
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/61474 |
作者单位 | 1.Predict Safety Testing Consortium, Crit Path Inst, Tucson, AZ USA; 2.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA; 3.Univ Konstanz, Constance, Germany; 4.US Environm Protect Agcy, Res Triangle Pk, NC USA; 5.Philip Morris Int R&D, Neuchatel, Switzerland; 6.Harvard Univ, Cambridge, MA 02138 USA; 7.Univ Massachusetts, Sch Publ Hlth, Andover, MA 01810 USA |
推荐引用方式 GB/T 7714 | Sauer, John Michael,Hartung, Thomas,Leist, Marcel,et al. Systems Toxicology: The Future of Risk Assessment[J]. 美国环保署,2015,34(4):346-348. |
APA | Sauer, John Michael,Hartung, Thomas,Leist, Marcel,Knudsen, Thomas B.,Hoeng, Julia,&Hayes, A. Wallace.(2015).Systems Toxicology: The Future of Risk Assessment.INTERNATIONAL JOURNAL OF TOXICOLOGY,34(4),346-348. |
MLA | Sauer, John Michael,et al."Systems Toxicology: The Future of Risk Assessment".INTERNATIONAL JOURNAL OF TOXICOLOGY 34.4(2015):346-348. |
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