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DOI | 10.1016/j.rvsc.2012.09.027 |
Cardiac structure and function in female carrier's of a canine model of Duchenne muscular dystrophy | |
Kane, A. M.1,2; DeFrancesco, T. C.2; Boyle, M. C.4; Malarkey, D. E.4; Ritchey, J. W.5; Atkins, C. E.2; Cullen, J. M.3; Kornegay, J. N.6; Keene, B. W.2 | |
发表日期 | 2013-06-01 |
ISSN | 0034-5288 |
卷号 | 94期号:3页码:610-617 |
英文摘要 | This investigation tested the hypothesis that carriers of golden retriever muscular dystrophy (GRMD), a genetically homologous condition of Duchenne muscular dystrophy (DMD), have quantifiable abnormalities in myocardial function, structure, or cardiac rhythm. Eleven GRMD carriers and four matched controls had cardiac evaluations and postmortem examinations. 24-h ECG Holter monitoring disclosed ventricular ectopy in 10 of 11 carriers and 2 of 4 controls. Conventional echocardiography failed to demonstrate significant differences between carriers and controls in systolic function. All carriers had multi-focal, minimal to marked myofiber necrosis, fibrosis, mineralization, inflammation, and/or fatty change in their hearts. Immunohistochemistry revealed a mosaic dystrophin deficiency in scattered cardiac myofibers in all carriers. No controls had cardiac histologic lesions; all had uniform dystrophin staining. Despite cardiac mosaic dystrophin expression and degenerative cardiac lesions, GRMD carriers at up to 3 years of age could not be distinguished statistically from normal controls by echocardiography or 24-h Holter monitoring. (C) 2012 Elsevier Ltd. All rights reserved. |
英文关键词 | Cardiomyopathy;Carrier;GRMD;Duchenne muscular dystrophy |
语种 | 英语 |
WOS记录号 | WOS:000318380600041 |
来源期刊 | RESEARCH IN VETERINARY SCIENCE |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/61471 |
作者单位 | 1.Angell Anim Med Ctr, Jamaica Plain, MA 02130 USA; 2.N Carolina State Univ, Dept Clin Sci, Coll Vet Med, Raleigh, NC 27607 USA; 3.N Carolina State Univ, Coll Vet Med, Dept Populat Hlth & Pathobiol, Raleigh, NC 27607 USA; 4.Natl Inst Environm Hlth Sci, Cellular & Mol Pathol Branch, Res Triangle Pk, NC USA; 5.Oklahoma State Univ, Coll Vet Med, Dept Vet Pathobiol, Stillwater, OK 74078 USA; 6.Texas A&M Univ, Coll Vet Med, Dept Vet Integrat Biosci, College Stn, TX 77843 USA |
推荐引用方式 GB/T 7714 | Kane, A. M.,DeFrancesco, T. C.,Boyle, M. C.,et al. Cardiac structure and function in female carrier's of a canine model of Duchenne muscular dystrophy[J]. 美国环保署,2013,94(3):610-617. |
APA | Kane, A. M..,DeFrancesco, T. C..,Boyle, M. C..,Malarkey, D. E..,Ritchey, J. W..,...&Keene, B. W..(2013).Cardiac structure and function in female carrier's of a canine model of Duchenne muscular dystrophy.RESEARCH IN VETERINARY SCIENCE,94(3),610-617. |
MLA | Kane, A. M.,et al."Cardiac structure and function in female carrier's of a canine model of Duchenne muscular dystrophy".RESEARCH IN VETERINARY SCIENCE 94.3(2013):610-617. |
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