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DOI | 10.1016/j.fct.2013.12.029 |
Development of a consumer product ingredient database for chemical exposure screening and prioritization | |
Goldsmith, M. -R.1; Grulke, C. M.1; Brooks, R. D.2; Transue, T. R.3; Tan, Y. M.1; Frame, A.1,5; Egeghy, P. P.1; Edwards, R.4; Chang, D. T.1; Tornero-Velez, R.1; Isaacs, K.1; Wang, A.1,5; Johnson, J.1; Holm, K.1; Reich, M.6; Mitchell, J.7; Vallero, D. A.1; Phillips, L.1; Phillips, M.1; Wambaugh, J. F.1; Judson, R. S.1; Buckley, T. J.1; Dary, C. C.1 | |
发表日期 | 2014-03-01 |
ISSN | 0278-6915 |
卷号 | 65页码:269-279 |
英文摘要 | Consumer products are a primary source of chemical exposures, yet little structured information is available on the chemical ingredients of these products and the concentrations at which ingredients are present. To address this data gap, we created a database of chemicals in consumer products using product Material Safety Data Sheets (MSDSs) publicly provided by a large retailer. The resulting database represents 1797 unique chemicals mapped to 8921 consumer products and a hierarchy of 353 consumer product "use categories" within a total of 15 top-level categories. We examine the utility of this database and discuss ways in which it will support (i) exposure screening and prioritization, (ii) generic or framework formulations for several indoor/consumer product exposure modeling initiatives, (iii) candidate chemical selection for monitoring near field exposure from proximal sources, and (iv) as activity tracers or ubiquitous exposure sources using "chemical space" map analyses. Chemicals present at high concentrations and across multiple consumer products and use categories that hold high exposure potential are identified. Our database is publicly available to serve regulators, retailers, manufacturers, and the public for predictive screening of chemicals in new and existing consumer products on the basis of exposure and risk. Published by Elsevier Ltd. |
英文关键词 | Chemical exposure;Consumer products;Ingredients;Product formulation;Near field exposure;Exposure prioritization |
语种 | 英语 |
WOS记录号 | WOS:000332500500034 |
来源期刊 | FOOD AND CHEMICAL TOXICOLOGY
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/61448 |
作者单位 | 1.US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA; 2.US EPA, Res Triangle Pk, NC 27711 USA; 3.Lockheed Martin Informat Technol, Res Triangle Pk, NC 27711 USA; 4.N Carolina State Univ, Raleigh, NC 27695 USA; 5.Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA; 6.Univ N Carolina, Chapel Hill, NC 27514 USA; 7.Michigan State Univ, E Lansing, MI 48824 USA |
推荐引用方式 GB/T 7714 | Goldsmith, M. -R.,Grulke, C. M.,Brooks, R. D.,et al. Development of a consumer product ingredient database for chemical exposure screening and prioritization[J]. 美国环保署,2014,65:269-279. |
APA | Goldsmith, M. -R..,Grulke, C. M..,Brooks, R. D..,Transue, T. R..,Tan, Y. M..,...&Dary, C. C..(2014).Development of a consumer product ingredient database for chemical exposure screening and prioritization.FOOD AND CHEMICAL TOXICOLOGY,65,269-279. |
MLA | Goldsmith, M. -R.,et al."Development of a consumer product ingredient database for chemical exposure screening and prioritization".FOOD AND CHEMICAL TOXICOLOGY 65(2014):269-279. |
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