气候变化领域集成服务门户

Manganese (Mn), an essential element, can be neurotoxic in high doses. This cross-sectional study explored the cognitive function of adults residing in two towns (Marietta and East Liverpool, Ohio, USA) identified as having high levels of environmental airborne Mn from industrial sources. Air-Mn site surface emissions method modeling for total suspended particulate (TSP) ranged from 0.03 to 1.61 mu g/m(3) in Marietta and 0.01-6.32 mu g/m(3) in East Liverpool. A comprehensive screening test battery of cognitive function, including the domains of abstract thinking, attention/concentration, executive function and memory was administered. The mean age of the participants was 56 years (+/- 10.8 years). Participants were mostly female (59.1) and primarily white (94.6%). Significant relationships (p < 0.05) were found between Mn exposure and performance on working and visuospatial memory (e.g., Rey-O Immediate beta = -0.19, Rey-O Delayed beta = -0.16) and verbal skills (e.g., Similarities beta = -0.19). Using extensive cognitive testing and computer modeling of 10-plus years of measured air monitoring data, this study suggests that long-term environmental exposure to high levels of air-Mn, the exposure metric of this paper, may result in mild deficits of cognitive function in adult populations. (C) 2015 Elsevier Inc. All rights reserved.