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DOI | 10.1016/j.scitotenv.2015.09.084 |
Environmental exposure to manganese in air: Associations with tremor and motor function | |
Bowler, Rosemarie M.1; Beseler, Cheryl L.2; Gocheva, Vihra V.1; Colledge, Michelle3; Kornblith, Erica S.4; Julian, Jaime R.5; Kim, Yangho6; Bollweg, George5; Lobdell, Danelle T.7 | |
发表日期 | 2016-01-15 |
ISSN | 0048-9697 |
卷号 | 541页码:646-654 |
英文摘要 | Background: Manganese (Mn) inhalation has been associated with neuropsychological and neurological sequelae in exposed workers. Few environmental epidemiologic studies have examined the potentially neurotoxic effects of Mn exposure in ambient air on motor function and hand tremor in adult community residents. Mn exposed residents were recruited in two Ohio towns: Mariella, a town near a ferro-manganese smeller, and East Liverpool, a town adjacent to a facility processing, crushing, screening, and packaging Mn products. Methods: Chronic (>= 10 years) exposure to ambient air Mn in adult residents and effects on neuropsychological and neurological outcomes were invesligated. Participants from Mariella (n = 100) and East Liverpool (n 86) were combined for analyses. AERMOD dispersion modeling of fixed-site outdoor air monitoring data estimated Mn inhalation over a ten year period. Adult Mn-exposed resident's psychomotor ability was assessed using Finger Tapping, Hand Dynamometer, Grooved Pegboard, and the Computerized Adaptive Testing System (CATSYS) Tremor system. Bayesian structural equation modeling was used to assess associations between air Mn and motor function and tremor. Results: Air-Mn exposure was significantly correlated in bivariate analyses with the tremor test (CATSYS) for intensity, center frequency and harmonic index. The Bayesian path analysis model showed associations of air-Mn with the CATSYS non-dominant center frequency and harmonic index; while the Bayesian structural equation model revealed associations between air-Mn and lower Finger Tapping scores. Household income was significantly associated with motor dysfunction but not with tremor. Conclusion: Tremor and motor function were associated with higher exposure to airborne Mn. (C) 2015 Elsevier B.V. All rights reserved. |
英文关键词 | Manganese;Neurotoxicity;Psychomotor;Tremor;Environment;Adult residents |
语种 | 英语 |
WOS记录号 | WOS:000365289300069 |
来源期刊 | SCIENCE OF THE TOTAL ENVIRONMENT
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/61300 |
作者单位 | 1.San Francisco State Univ, Dept Psychol, San Francisco, CA 94132 USA; 2.Colorado State Univ, Ft Collins, CO 80523 USA; 3.ATSDR, Chicago, IL USA; 4.Alliant Int Univ, Calif Sch Profess Psychol, San Francisco, CA USA; 5.US EPA, Chicago, IL USA; 6.Univ Ulsan, Coll Med, Dept Occupat & Environm Med, Ulsan Univ Hosp, Ulsan 680749, South Korea; 7.US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA |
推荐引用方式 GB/T 7714 | Bowler, Rosemarie M.,Beseler, Cheryl L.,Gocheva, Vihra V.,et al. Environmental exposure to manganese in air: Associations with tremor and motor function[J]. 美国环保署,2016,541:646-654. |
APA | Bowler, Rosemarie M..,Beseler, Cheryl L..,Gocheva, Vihra V..,Colledge, Michelle.,Kornblith, Erica S..,...&Lobdell, Danelle T..(2016).Environmental exposure to manganese in air: Associations with tremor and motor function.SCIENCE OF THE TOTAL ENVIRONMENT,541,646-654. |
MLA | Bowler, Rosemarie M.,et al."Environmental exposure to manganese in air: Associations with tremor and motor function".SCIENCE OF THE TOTAL ENVIRONMENT 541(2016):646-654. |
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