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DOI10.1021/es4027248
The Triggering of Myocardial Infarction by Fine Particles Is Enhanced When Particles Are Enriched in Secondary Species
Rich, David Q.1; Oezkaynak, Haluk2; Crooks, James2; Baxter, Lisa2; Burke, Janet2; Ohman-Strickland, Pamela3; Thevenet-Morrison, Kelly1; Kipen, Howard M.4,5; Zhang, Junfeng6; Kostis, John B.5; Lunden, Melissa7; Hodas, Natasha8; Turpin, Barbara J.8
发表日期2013-08-20
ISSN0013-936X
卷号47期号:16页码:9414-9423
英文摘要

Previous studies have reported an increased risk of myocardial infarction (MI) associated with acute increases in PM concentration. Recently, we reported that MI/fine particle (PM2.5) associations may be limited to transmural infarctions. In this study, we retained data on hospital discharges with a primary diagnosis of acute myocardial infarction (using International Classification of Diseases ninth Revision [ICD-9] codes), for those admitted January 1, 2004 to December 31, 2006, who were >= 18 years of age, and were residents of New Jersey at the time of their MI. We excluded MI with a diagnosis of a previous MI and MI coded as a subendocardial infarction, leaving n = 1563 transmural infarctions available for analysis. We coupled these health data with PM2.5 species concentrations predicted by the Community Multiscale Air Quality chemical transport model, ambient PM2.5 concentrations, and used the same case-crossover methods to evaluate whether the relative odds of transmural MI associated with increased PM2.5 concentration is modified by the PM2.5 composition/mixture (i.e., mass fractions of sulfate, nitrate, elemental carbon, organic carbon, and ammonium). We found the largest relative odds estimates on the days with the highest tertile of sulfate mass fraction (OR = 1.13; 95% CI = 1.00, 1.27), nitrate mass fraction (OR = 1.18; 95% CI = 0.98, 1.35), and ammonium mass fraction (OR = 1.13; 95% CI = 1.00 1.28), and the lowest tertile of EC mass fraction (OR = 1.17; 95% CI = 1.03, 1.34). Air pollution mixtures on these days were enhanced in pollutants formed through atmospheric chemistry (i.e., secondary PM2.5) and depleted in primary pollutants (e.g., EC). When mixtures were laden with secondary PM species (sulfate, nitrate, and/or organics), we observed larger relative odds of myocardial infarction associated with increased PM2.5 concentrations. Further work is needed to confirm these findings and examine which secondary PM2.5 component(s) is/are responsible for an acute MI response.


语种英语
WOS记录号WOS:000323471700052
来源期刊ENVIRONMENTAL SCIENCE & TECHNOLOGY
来源机构美国环保署
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/61288
作者单位1.Univ Rochester, Sch Med & Dent, Rochester, NY 14642 USA;
2.US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA;
3.Rutgers State Univ, Sch Publ Hlth, Piscataway, NJ USA;
4.Rutgers State Univ, Robert Wood Johnson Med Sch, Environm & Occupat Hlth Sci Inst, Piscataway, NJ 08854 USA;
5.Rutgers State Univ, Robert Wood Johnson Med Sch, MIDAS Study Grp 19, Piscataway, NJ 08854 USA;
6.Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA;
7.Lawrence Berkeley Natl Labs, Environm Energy Technol Div, Berkeley, CA USA;
8.Rutgers State Univ, Sch Environm & Biol Sci, New Brunswick, NJ 08903 USA
推荐引用方式
GB/T 7714
Rich, David Q.,Oezkaynak, Haluk,Crooks, James,et al. The Triggering of Myocardial Infarction by Fine Particles Is Enhanced When Particles Are Enriched in Secondary Species[J]. 美国环保署,2013,47(16):9414-9423.
APA Rich, David Q..,Oezkaynak, Haluk.,Crooks, James.,Baxter, Lisa.,Burke, Janet.,...&Turpin, Barbara J..(2013).The Triggering of Myocardial Infarction by Fine Particles Is Enhanced When Particles Are Enriched in Secondary Species.ENVIRONMENTAL SCIENCE & TECHNOLOGY,47(16),9414-9423.
MLA Rich, David Q.,et al."The Triggering of Myocardial Infarction by Fine Particles Is Enhanced When Particles Are Enriched in Secondary Species".ENVIRONMENTAL SCIENCE & TECHNOLOGY 47.16(2013):9414-9423.
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