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DOI10.1002/etc.4163
A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17-trenbolone
Ankley, Gerald T.1; Coady, Katherine K.2; Gross, Melanie3; Holbech, Henrik4; Levine, Steven L.5; Maack, Gerd6; Williams, Mike7
发表日期2018-08-01
ISSN0730-7268
卷号37期号:8页码:2064-2078
英文摘要

Trenbolone acetate is widely used in some parts of the world for its desirable anabolic effects on livestock. Several metabolites of the acetate, including 17-trenbolone, have been detected at low nanograms per liter concentrations in surface waters associated with animal feedlots. The 17-trenbolone isomer can affect androgen receptor signaling pathways in various vertebrate species at comparatively low concentrations/doses. The present article provides a comprehensive review and synthesis of the existing literature concerning exposure to and biological effects of 17-trenbolone, with an emphasis on potential risks to aquatic animals. In vitro studies indicate that, although 17-trenbolone can activate several nuclear hormone receptors, its highest affinity is for the androgen receptor in all vertebrate taxa examined, including fish. Exposure of fish to nanograms per liter water concentrations of 17-trenbolone can cause changes in endocrine function in the short term, and adverse apical effects in longer exposures during development and reproduction. Impacts on endocrine function typically are indicative of inappropriate androgen receptor signaling, such as changes in sex steroid metabolism, impacts on gonadal stage, and masculinization of females. Exposure of fish to 17-trenbolone during sexual differentiation in early development can greatly skew sex ratios, whereas adult exposures can adversely impact fertility and fecundity. To fully assess ecosystem-level risks, additional research is warranted to address uncertainties as to the degree/breadth of environmental exposures and potential population-level effects of 17-trenbolone in sensitive species. Environ Toxicol Chem 2018;37:2064-2078. Published 2018 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.


英文关键词17-Trenbolone;Exposure;Effects;Review
语种英语
WOS记录号WOS:000439771200002
来源期刊ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
来源机构美国环保署
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/61101
作者单位1.US EPA, Off Res & Dev, Duluth, MN 55804 USA;
2.Dow Chem Co USA, Toxicol & Environm Res & Consulting, Midland, MI 48674 USA;
3.Wca, Farringdon, England;
4.Univ Southern Denmark, Dept Biol, Odense M, Denmark;
5.Global Regulatory Sci, St Louis, MO USA;
6.German Environm Agcy, Dessau Rosslau, Germany;
7.CSIRO Land & Water, Waite Campus, Adelaide, SA, Australia
推荐引用方式
GB/T 7714
Ankley, Gerald T.,Coady, Katherine K.,Gross, Melanie,et al. A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17-trenbolone[J]. 美国环保署,2018,37(8):2064-2078.
APA Ankley, Gerald T..,Coady, Katherine K..,Gross, Melanie.,Holbech, Henrik.,Levine, Steven L..,...&Williams, Mike.(2018).A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17-trenbolone.ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,37(8),2064-2078.
MLA Ankley, Gerald T.,et al."A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17-trenbolone".ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 37.8(2018):2064-2078.
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