Climate Change Data Portal
DOI | 10.1002/etc.4163 |
A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17-trenbolone | |
Ankley, Gerald T.1; Coady, Katherine K.2; Gross, Melanie3; Holbech, Henrik4; Levine, Steven L.5; Maack, Gerd6; Williams, Mike7 | |
发表日期 | 2018-08-01 |
ISSN | 0730-7268 |
卷号 | 37期号:8页码:2064-2078 |
英文摘要 | Trenbolone acetate is widely used in some parts of the world for its desirable anabolic effects on livestock. Several metabolites of the acetate, including 17-trenbolone, have been detected at low nanograms per liter concentrations in surface waters associated with animal feedlots. The 17-trenbolone isomer can affect androgen receptor signaling pathways in various vertebrate species at comparatively low concentrations/doses. The present article provides a comprehensive review and synthesis of the existing literature concerning exposure to and biological effects of 17-trenbolone, with an emphasis on potential risks to aquatic animals. In vitro studies indicate that, although 17-trenbolone can activate several nuclear hormone receptors, its highest affinity is for the androgen receptor in all vertebrate taxa examined, including fish. Exposure of fish to nanograms per liter water concentrations of 17-trenbolone can cause changes in endocrine function in the short term, and adverse apical effects in longer exposures during development and reproduction. Impacts on endocrine function typically are indicative of inappropriate androgen receptor signaling, such as changes in sex steroid metabolism, impacts on gonadal stage, and masculinization of females. Exposure of fish to 17-trenbolone during sexual differentiation in early development can greatly skew sex ratios, whereas adult exposures can adversely impact fertility and fecundity. To fully assess ecosystem-level risks, additional research is warranted to address uncertainties as to the degree/breadth of environmental exposures and potential population-level effects of 17-trenbolone in sensitive species. Environ Toxicol Chem 2018;37:2064-2078. Published 2018 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. |
英文关键词 | 17-Trenbolone;Exposure;Effects;Review |
语种 | 英语 |
WOS记录号 | WOS:000439771200002 |
来源期刊 | ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/61101 |
作者单位 | 1.US EPA, Off Res & Dev, Duluth, MN 55804 USA; 2.Dow Chem Co USA, Toxicol & Environm Res & Consulting, Midland, MI 48674 USA; 3.Wca, Farringdon, England; 4.Univ Southern Denmark, Dept Biol, Odense M, Denmark; 5.Global Regulatory Sci, St Louis, MO USA; 6.German Environm Agcy, Dessau Rosslau, Germany; 7.CSIRO Land & Water, Waite Campus, Adelaide, SA, Australia |
推荐引用方式 GB/T 7714 | Ankley, Gerald T.,Coady, Katherine K.,Gross, Melanie,et al. A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17-trenbolone[J]. 美国环保署,2018,37(8):2064-2078. |
APA | Ankley, Gerald T..,Coady, Katherine K..,Gross, Melanie.,Holbech, Henrik.,Levine, Steven L..,...&Williams, Mike.(2018).A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17-trenbolone.ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,37(8),2064-2078. |
MLA | Ankley, Gerald T.,et al."A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17-trenbolone".ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 37.8(2018):2064-2078. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。