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Historically, ecological risk assessments have rarely included amphibian species, focusing preferentially on other aquatic (fish, invertebrates, algae) and terrestrial wildlife (birds and mammal) species. Often this lack of consideration is due to a paucity of toxicity data, significant variation in study design, uncertainty with regard to exposure, or a combination of all three. Productive risk assessments for amphibians are particularly challenging, given variations in complex life history strategies. Further consideration is needed for the development of useful laboratory animal models and appropriate experimental test procedures that can be effectively applied to the examination of biological response patterns. Using these standardized techniques, risk estimates can be more accurately defined to ensure adequate protection of amphibians from a variety of stress agents. Patterns in toxicity may help to ascertain whether test results from 1 amphibian group (e.g., Urodela) could be sufficiently protective of another (e.g., Anura) and/or whether some nonamphibian aquatic taxonomic groups (e.g., fish or aquatic invertebrates) may be representative of aquatic amphibian life stages. This scope is intended to be a guide in the development of methods that would yield data appropriate for ecological risk decisions applicable to amphibians. Integr Environ Assess Manag 2017;13:601-613. (c) 2016 SETAC