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DOI | 10.1093/toxsci/kfu187 |
Inhaled Diesel Emissions Generated with Cerium Oxide Nanoparticle Fuel Additive Induce Adverse Pulmonary and Systemic Effects | |
Snow, Samantha J.1,2; McGee, John2; Miller, Desinia B.1; Bass, Virginia3; Schladweiler, Mette C.2; Thomas, Ronald F.2; Krantz, Todd2; King, Charly2; Ledbetter, Allen D.2; Richards, Judy2; Weinstein, Jason P.4; Conner, Teri4; Willis, Robert4; Linak, William P.5; Nash, David5,6; Wood, Charles E.7; Elmore, Susan A.8; Morrison, James P.9; Johnson, Crystal L.9; Gilmour, Matthew Ian2; Kodavanti, Urmila P.2 | |
发表日期 | 2014-12-01 |
ISSN | 1096-6080 |
卷号 | 142期号:2页码:403-417 |
英文摘要 | Diesel exhaust (DE) exposure induces adverse cardiopulmonary effects. Cerium oxide nanoparticles added to diesel fuel (DECe) increases fuel burning efficiency but leads to altered emission characteristics and potentially altered health effects. Here, we evaluated whether DECe results in greater adverse pulmonary effects compared with DE. Male Sprague Dawley rats were exposed to filtered air, DE, or DECe for 5 h/day for 2 days. N-acetyl glucosaminidase activity was increased in bronchial alveolar lavage fluid (BALF) of rats exposed to DECe but not DE. There were also marginal but insignificant increases in several other lung injury biomarkers in both exposure groups (DECe>DE for all). To further characterize DECe toxicity, rats in a second study were exposed to filtered air or DECe for 5 h/day for 2 days or 4 weeks. Tissue analysis indicated a concentration-and time-dependent accumulation of lung and liver cerium followed by a delayed clearance. The gas-phase and high concentration of DECe increased lung inflammation at the 2-day time point, indicating that gas-phase components, in addition to particles, contribute to pulmonary toxicity. This effect was reduced at 4 weeks except for a sustained increase in BALF gamma-glutamyl transferase activity. Histopathology and transmission electron microscopy revealed increased alveolar septa thickness due to edema and increased numbers of pigmented macrophages after DECe exposure. Collectively, these findings indicate that DECe induces more adverse pulmonary effects on a mass basis than DE. In addition, lung accumulation of cerium, systemic translocation to the liver, and delayed clearance are added concerns to existing health effects of DECe. |
英文关键词 | diesel exhaust;cerium oxide;cardiopulmonary;nanoparticle |
语种 | 英语 |
WOS记录号 | WOS:000347617800010 |
来源期刊 | TOXICOLOGICAL SCIENCES
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/60815 |
作者单位 | 1.Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA; 2.US EPA, Environm Publ Hlth Div, NHEERL, Res Triangle Pk, NC 27711 USA; 3.Univ N Carolina, Gillings Sch Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA; 4.US EPA, Environm Characterizat & Apportionment Branch, NERL, Res Triangle Pk, NC 27711 USA; 5.US EPA, Air Pollut Prevent & Control Div, NRMRL, Res Triangle Pk, NC 27711 USA; 6.Arcadis US Inc, Durham, NC 27713 USA; 7.US EPA, Integrated Syst Toxicol Div, NHEERL, Res Triangle Pk, NC 27711 USA; 8.Natl Inst Environm Hlth Sci, Natl Toxicol Program Div, Res Triangle Pk, NC 27711 USA; 9.Pathol Associates Inc, Charles River Labs, Durham, NC 27703 USA |
推荐引用方式 GB/T 7714 | Snow, Samantha J.,McGee, John,Miller, Desinia B.,et al. Inhaled Diesel Emissions Generated with Cerium Oxide Nanoparticle Fuel Additive Induce Adverse Pulmonary and Systemic Effects[J]. 美国环保署,2014,142(2):403-417. |
APA | Snow, Samantha J..,McGee, John.,Miller, Desinia B..,Bass, Virginia.,Schladweiler, Mette C..,...&Kodavanti, Urmila P..(2014).Inhaled Diesel Emissions Generated with Cerium Oxide Nanoparticle Fuel Additive Induce Adverse Pulmonary and Systemic Effects.TOXICOLOGICAL SCIENCES,142(2),403-417. |
MLA | Snow, Samantha J.,et al."Inhaled Diesel Emissions Generated with Cerium Oxide Nanoparticle Fuel Additive Induce Adverse Pulmonary and Systemic Effects".TOXICOLOGICAL SCIENCES 142.2(2014):403-417. |
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