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DOI | 10.1186/1743-8977-11-25 |
PM2.5-induced cardiovascular dysregulation in rats is associated with elemental carbon and temperature-resolved carbon subfractions | |
Wagner, James G.1,2,6; Kamal, Ali S.3; Morishita, Masako4; Dvonch, J. Timothy4; Harkema, Jack R.1,2; Rohr, Annette C.5 | |
发表日期 | 2014-05-22 |
ISSN | 1743-8977 |
卷号 | 11 |
英文摘要 | Background: We tested the hypothesis that cardiovascular responses to PM2.5 exposure will be enhanced in hypertensive rats and linked to specific carbonaceous pollutants in an urban industrial setting. Methods: Spontaneously hypertensive rats were exposed by inhalation to concentrated PM2.5 in an industrial area of Dearborn, Michigan, for four consecutive summer days. Blood pressure (BP), heart rate (HR) and HR variability (HRV) metrics (SDNN, RMSSD) were assessed by radiotelemetry and compared to 1 h-and 8 h-averaged fluctuations in PM2.5 composition, with a focus on elemental and organic carbon (EC and OC, respectively), and temperature-resolved subfractions (EC1-EC5, PC (pyrolized carbon), and OC1-OC4), as well as other major and minor PM components. Results: Mean HR and BP were increased, while HRV was decreased over 4 days of exposure. Using 1 h averages, EC (1 mu g/m(3) increase) was associated with increased HR of 11-32 bpm (4-11% increase), 1.2-1.5 ms (22-27%) decreases in SDNN, 3-14 mmHg (1.5-8%) increases in systolic BP, and 5-12 mmHg (4-9%) increases in diastolic BP. By comparison, associations with OC were negligible. Using 8 h averages, EC subfractions were linked with increased heart rate (EC1: 13 bpm; EC2, EC3, PC: < 5 bpm) and SDNN (EC1> > EC2 > EC3, EC4, PC), but with decreased RMSSD (EC2, EC5 > EC3, EC4). Minimal effects were associated with OC and OC1. Associations between carbon subfractions and BP were negligible. Associations with non-carbonaceous components and trace elements were generally non-significant or of negligible effect size. Conclusions: These findings are the first to describe associations between acute cardiovascular responses and thermally resolved carbon subfractions. We report that cardiovascular responses to PM2.5 carbonaceous materials appear to be driven by EC and its EC1 fraction. |
英文关键词 | Air pollution;Blood pressure;Elemental carbon;Heart rate;Inhalation;Organic carbon;PM2.5;Rat |
语种 | 英语 |
WOS记录号 | WOS:000336985500001 |
来源期刊 | PARTICLE AND FIBRE TOXICOLOGY
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/60525 |
作者单位 | 1.Michigan State Univ, Dept Pathobiol & Diagnost Invest, E Lansing, MI 48824 USA; 2.Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA; 3.US EPA, Human Exposure & Atmospher Sci Div, NERL, Res Triangle Pk, NC 27711 USA; 4.Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA; 5.Elect Power Res Inst, Palo Alto, CA USA; 6.Michigan State Univ, E Lansing, MI 48824 USA |
推荐引用方式 GB/T 7714 | Wagner, James G.,Kamal, Ali S.,Morishita, Masako,et al. PM2.5-induced cardiovascular dysregulation in rats is associated with elemental carbon and temperature-resolved carbon subfractions[J]. 美国环保署,2014,11. |
APA | Wagner, James G.,Kamal, Ali S.,Morishita, Masako,Dvonch, J. Timothy,Harkema, Jack R.,&Rohr, Annette C..(2014).PM2.5-induced cardiovascular dysregulation in rats is associated with elemental carbon and temperature-resolved carbon subfractions.PARTICLE AND FIBRE TOXICOLOGY,11. |
MLA | Wagner, James G.,et al."PM2.5-induced cardiovascular dysregulation in rats is associated with elemental carbon and temperature-resolved carbon subfractions".PARTICLE AND FIBRE TOXICOLOGY 11(2014). |
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