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DOI | 10.1289/ehp.1307893 |
The Navigation Guide-Evidence-Based Medicine Meets Environmental Health: Systematic Review of Human Evidence for PFOA Effects on Fetal Growth | |
Johnson, Paula I.1; Sutton, Patrice1; Atchley, Dylan S.1; Koustas, Erica2; Lam, Juleen2; Sen, Saunak3; Robinson, Karen A.4,5,6; Axelrad, Daniel A.7; Woodruff, Tracey J.1 | |
发表日期 | 2014-10-01 |
ISSN | 0091-6765 |
卷号 | 122期号:10页码:1028-1039 |
英文摘要 | BACKGROUND: The Navigation Guide methodology was developed to meet the need for a robust method of systematic and transparent research synthesis in environmental health science. We conducted a case study systematic review to support proof of concept of the method. OBJECTIVE: We applied the Navigation Guide systematic review methodology to determine whether developmental exposure to perfluorooctanoic acid (PFOA) affects fetal growth in humans. METHODS: We applied the first 3 steps of the Navigation Guide methodology to human epidemiological data: 1) specify the study question, 2) select the evidence, and 3) rate the quality and strength of the evidence. We developed a protocol, conducted a comprehensive search of the literature, and identified relevant studies using prespecified criteria. We evaluated each study for risk of bias and conducted meta-analyses on a subset of studies. We rated quality and strength of the entire body of human evidence. RESULTS: We identified 18 human studies that met our inclusion criteria, and 9 of these were combined through meta-analysis. Through meta-analysis, we estimated that a 1-ng/mL increase in serum or plasma PFOA was associated with a -18.9 g (95% CI: -29.8, -7.9) difference in birth weight. We concluded that the risk of bias across studies was low, and we assigned a "moderate" quality rating to the overall body of human evidence. CONCLUSION: On the basis of this first application of the Navigation Guide systematic review methodology, we concluded that there is "sufficient" human evidence that developmental exposure to PFOA reduces fetal growth. |
语种 | 英语 |
WOS记录号 | WOS:000343136200014 |
来源期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/60437 |
作者单位 | 1.Univ Calif San Francisco, Program Reprod Hlth & Environm, Oakland, CA USA; 2.US EPA, Oak Ridge Inst Sci & Educ ORISE Postdoctoral Fell, Natl Ctr Environm Econ, Off Policy, Washington, DC 20460 USA; 3.Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA; 4.Johns Hopkins Univ, Dept Med, Baltimore, MD USA; 5.Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA; 6.Johns Hopkins Univ, Dept Hlth Policy & Management, Baltimore, MD 21218 USA; 7.US EPA, Natl Ctr Environm Econ, Off Policy, Washington, DC 20460 USA |
推荐引用方式 GB/T 7714 | Johnson, Paula I.,Sutton, Patrice,Atchley, Dylan S.,et al. The Navigation Guide-Evidence-Based Medicine Meets Environmental Health: Systematic Review of Human Evidence for PFOA Effects on Fetal Growth[J]. 美国环保署,2014,122(10):1028-1039. |
APA | Johnson, Paula I..,Sutton, Patrice.,Atchley, Dylan S..,Koustas, Erica.,Lam, Juleen.,...&Woodruff, Tracey J..(2014).The Navigation Guide-Evidence-Based Medicine Meets Environmental Health: Systematic Review of Human Evidence for PFOA Effects on Fetal Growth.ENVIRONMENTAL HEALTH PERSPECTIVES,122(10),1028-1039. |
MLA | Johnson, Paula I.,et al."The Navigation Guide-Evidence-Based Medicine Meets Environmental Health: Systematic Review of Human Evidence for PFOA Effects on Fetal Growth".ENVIRONMENTAL HEALTH PERSPECTIVES 122.10(2014):1028-1039. |
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