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DOI | 10.1016/j.ntt.2015.08.010 |
Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish | |
Jarema, Kimberly A.1; Hunter, Deborah L.2; Shaffer, Rachel M.2,3; Behl, Mamta4; Padilla, Stephanie2 | |
发表日期 | 2015-11-01 |
ISSN | 0892-0362 |
卷号 | 52页码:194-209 |
英文摘要 | As polybrominated diphenyl ethers are phased out, numerous compounds are emerging as potential replacement flame retardants for use in consumer and electronic products. Little is known, however, about the neurobehavioral toxicity of these replacements. This study evaluated the neurobehavioral effects of acute or developmental exposure to t-butylphenyl diphenyl phosphate (BPDP), 2-ethylhexyl diphenyl phosphate (EHDP), isodecyl diphenyl phosphate (IDDP), isopropylated phenyl phosphate (IPP), tricresyl phosphate (TMPP; also abbreviated TCP), triphenyl phosphate (TPHP; also abbreviated TPP), tetrabromobisphenol A (TBBPA), tris (2-chloroethyl) phosphate (TCEP), tris (1,3-dichloroisopropyl) phosphate (TDCIPP; also abbreviated TDCPP), tri-o-cresyl phosphate (TOCP), and 2,2-,4,4'-tetrabromodiphenyl ether (BDE-47) in zebrafish (Danio redo) larvae. Larvae (n approximate to 24 per dose per compound) were exposed to test compounds (0.4-120 mu M) at subteratogenic concentrations either developmentally or acutely, and locomotor activity was assessed at 6 days post fertilization. When given developmentally, all chemicals except BPDP, IDDP and TBBPA produced behavioral effects. When given acutely, all chemicals produced behavioral effects, with TPHP, TBBPA, EHDP, IPP, and BPDP eliciting the most effects at the most concentrations. The results indicate that these replacement flame retardants may have developmental or pharmacological effects on the vertebrate nervous system. Published by Elsevier Inc. |
英文关键词 | Zebrafish;Neurotoxicity;Flame retardants;Developmental;Acute |
语种 | 英语 |
WOS记录号 | WOS:000367108400010 |
来源期刊 | NEUROTOXICOLOGY AND TERATOLOGY
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/60379 |
作者单位 | 1.US EPA, Toxicol Assessment Div, NHEERL, Res Triangle Pk, NC 27711 USA; 2.US EPA, Integrated Syst Toxicol Div, NHEERL, Res Triangle Pk, NC 27711 USA; 3.Univ N Carolina, Sch Med, Curriculum Toxicol, Chapel Hill, NC USA; 4.NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA |
推荐引用方式 GB/T 7714 | Jarema, Kimberly A.,Hunter, Deborah L.,Shaffer, Rachel M.,et al. Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish[J]. 美国环保署,2015,52:194-209. |
APA | Jarema, Kimberly A.,Hunter, Deborah L.,Shaffer, Rachel M.,Behl, Mamta,&Padilla, Stephanie.(2015).Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish.NEUROTOXICOLOGY AND TERATOLOGY,52,194-209. |
MLA | Jarema, Kimberly A.,et al."Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish".NEUROTOXICOLOGY AND TERATOLOGY 52(2015):194-209. |
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