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DOI | 10.1097/EDE.0000000000000162 |
Outdoor Fine Particles and Nonfatal Strokes Systematic Review and Meta-analysis | |
Shin, Hwashin H.1,2; Fann, Neal3; Burnett, Richard T.1; Cohen, Aaron4; Hubbell, Bryan J.3 | |
发表日期 | 2014-11-01 |
ISSN | 1044-3983 |
卷号 | 25期号:6页码:835-842 |
英文摘要 | Background: Epidemiologic studies find that long-and short-term exposure to fine particles (PM2.5) is associated with adverse cardiovascular outcomes, including ischemic and hemorrhagic strokes. However, few systematic reviews or meta-analyses have synthesized these results. Methods: We reviewed epidemiologic studies that estimated the risks of nonfatal strokes attributable to ambient PM2.5. To pool risks among studies we used a random-effects model and 2 Bayesian approaches. The first Bayesian approach assumes a normal prior that allows risks to be zero, positive or negative. The second assumes a gamma prior, where risks can only be positive. This second approach is proposed when the number of studies pooled is small, and there is toxicological or clinical literature to support a causal relation. Results: We identified 20 studies suitable for quantitative meta-analysis. Evidence for publication bias is limited. The frequentist meta-analysis produced pooled risk ratios of 1.06 (95% confidence interval = 1.00-1.13) and 1.007 (1.003-1.010) for long-and short-term effects, respectively. The Bayesian meta-analysis found a posterior mean risk ratio of 1.08 (95% posterior interval = 0.96-1.26) and 1.008 (1.003-1.013) from a normal prior, and of 1.05 (1.02-1.10) and 1.008 (1.004-1.013) from a gamma prior, for long-and short-term effects, respectively, per 10 mu g/m(3) PM2.5. Conclusions: Sufficient evidence exists to develop a concentration-response relation for short-and long-term exposures to PM2.5 and stroke incidence. Long-term exposures to PM2.5 result in a higher risk ratio than short-term exposures, regardless of the pooling method. The evidence for short-term PM2.5-related ischemic stroke is especially strong. |
语种 | 英语 |
WOS记录号 | WOS:000343122000008 |
来源期刊 | EPIDEMIOLOGY
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/60160 |
作者单位 | 1.Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON K1A 0L2, Canada; 2.Queens Univ, Dept Math & Stat, Kingston, ON K7L 3N6, Canada; 3.US EPA, Hlth & Environm Impacts Div, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA; 4.Hlth Effects Inst, Boston, MA USA |
推荐引用方式 GB/T 7714 | Shin, Hwashin H.,Fann, Neal,Burnett, Richard T.,et al. Outdoor Fine Particles and Nonfatal Strokes Systematic Review and Meta-analysis[J]. 美国环保署,2014,25(6):835-842. |
APA | Shin, Hwashin H.,Fann, Neal,Burnett, Richard T.,Cohen, Aaron,&Hubbell, Bryan J..(2014).Outdoor Fine Particles and Nonfatal Strokes Systematic Review and Meta-analysis.EPIDEMIOLOGY,25(6),835-842. |
MLA | Shin, Hwashin H.,et al."Outdoor Fine Particles and Nonfatal Strokes Systematic Review and Meta-analysis".EPIDEMIOLOGY 25.6(2014):835-842. |
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