Climate Change Data Portal
DOI | 10.3109/08958378.2014.889257 |
Cardiovascular effects caused by increasing concentrations of diesel exhaust in middle-aged healthy GSTM1 null human volunteers | |
Tong, Haiyan1; Rappold, Ana G.1; Caughey, Melissa2; Hinderliter, Alan L.2; Graff, Donald W.3; Berntsen, Jon H.4; Cascio, Wayne E.1; Devlin, Robert B.1; Samet, James M.1 | |
发表日期 | 2014-05-01 |
ISSN | 0895-8378 |
卷号 | 26期号:6页码:319-326 |
英文摘要 | Context: Epidemiological studies have shown an association between the incidence of adverse cardiovascular effects and exposure to ambient particulate matter (PM). Diesel exhaust (DE) is a major contributor to ambient PM and gaseous emissions in urban areas. Objective: This was a pilot study designed to evaluate concentration-dependent effects of short-term exposure to whole DE on the cardiovascular system in order to identify a threshold concentration that can elicit biological responses in healthy human volunteers. Materials and methods: Six healthy middle-aged participants with glutathione-S-transferase-Mu 1 (GSTM1) null genotype underwent sequential exposures to 100 mu g/m(3), 200 mu g/m(3), and 300 mu g/m(3) whole DE generated in real time using an idling diesel truck engine. Exposures were separated by 14 d and each was 2 h in duration. Results: We report concentration-dependent effects of exposure to DE, with 100 mu g/m(3) concentration causing minimal cardiovascular effects, while exposure to 300 mu g/m(3) DE for 2 h resulted in a borderline significant reduction of baseline brachial artery diameter (3.34 +/- 0.27 mm pre-versus 3.23 +/- 0.25mm post-exposure; p = 0.08). Exposure to the highest concentration of DE also resulted in increases of 5 mmHg in diastolic blood pressure as well as a decrease in indices of the frequency domain of heart rate variability (HRV). Discussion and conclusions: These findings demonstrate that acute exposure to relatively high concentrations of DE produces cardiovascular changes in middle-aged GSTM1 null individuals. This study therefore suggests that arterial vasoconstriction and changes in HRV are responses through which traffic-related air pollution increases the risk of adverse cardiovascular outcomes. |
英文关键词 | Blood pressure;brachial artery ultrasound;diesel exhaust;GSTM1 null;heart rate variability;middle-aged healthy human participants |
语种 | 英语 |
WOS记录号 | WOS:000334746500001 |
来源期刊 | INHALATION TOXICOLOGY
![]() |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/59963 |
作者单位 | 1.US EPA, Environm Publ Hlth Div, NHEERL, Res Triangle Pk, NC 27711 USA; 2.Univ N Carolina, Dept Med, Chapel Hill Sch Med, Chapel Hill, NC USA; 3.Celerion, Lincoln, NE USA; 4.TRC Corp, Raleigh, NC USA |
推荐引用方式 GB/T 7714 | Tong, Haiyan,Rappold, Ana G.,Caughey, Melissa,et al. Cardiovascular effects caused by increasing concentrations of diesel exhaust in middle-aged healthy GSTM1 null human volunteers[J]. 美国环保署,2014,26(6):319-326. |
APA | Tong, Haiyan.,Rappold, Ana G..,Caughey, Melissa.,Hinderliter, Alan L..,Graff, Donald W..,...&Samet, James M..(2014).Cardiovascular effects caused by increasing concentrations of diesel exhaust in middle-aged healthy GSTM1 null human volunteers.INHALATION TOXICOLOGY,26(6),319-326. |
MLA | Tong, Haiyan,et al."Cardiovascular effects caused by increasing concentrations of diesel exhaust in middle-aged healthy GSTM1 null human volunteers".INHALATION TOXICOLOGY 26.6(2014):319-326. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。