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DOI | 10.1016/j.jcf.2012.10.010 |
Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients | |
Ghio, Andrew J.1; Roggli, Victor L.2; Soukup, Joleen M.1; Richards, Judy H.1; Randell, Scott H.3; Muhlebach, Marianne S.4 | |
发表日期 | 2013-07-01 |
ISSN | 1569-1993 |
卷号 | 12期号:4页码:390-398 |
英文摘要 | Oxidative stress participates in the pathophysiology of cystic fibrosis (CF). An underlying disruption in iron homeostasis can frequently be demonstrated in injuries and diseases associated with an oxidative stress. We tested the hypothesis that iron accumulation and altered expression of iron-related proteins could be demonstrated in both the bronchoalveolar lavage (BAL) fluid and explanted lungs of patients with cystic fibrosis. BAL fluid collected from 10 children with CF showed elevated concentrations of protein, iron, ferritin, transferrin, heme, and hemoglobin relative to that obtained from 20 healthy volunteers. Using Pen's Prussian blue staining, explanted lung from CF patients revealed increased iron in alveolar and interstitial macrophages. Similarly, there was an increased expression of ferritin, the iron importer DMT1, and the exporter ferroportin 1 in lung tissue from CF patients. We conclude that iron homeostasis is disrupted in CF patients with an accumulation of this metal and altered expression of iron-related proteins being evident in the lungs. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society. |
英文关键词 | Iron;Ferritin;Cystic fibrosis;Transferrin;Lung diseases |
语种 | 英语 |
WOS记录号 | WOS:000321088800011 |
来源期刊 | JOURNAL OF CYSTIC FIBROSIS
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/59946 |
作者单位 | 1.US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC 27599 USA; 2.Duke Univ, Dept Pathol, Durham, NC 27706 USA; 3.Univ N Carolina, Cyst Fibrosis Ctr, Chapel Hill, NC 27599 USA; 4.Univ N Carolina, Dept Pediat, Chapel Hill, NC 27599 USA |
推荐引用方式 GB/T 7714 | Ghio, Andrew J.,Roggli, Victor L.,Soukup, Joleen M.,et al. Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients[J]. 美国环保署,2013,12(4):390-398. |
APA | Ghio, Andrew J.,Roggli, Victor L.,Soukup, Joleen M.,Richards, Judy H.,Randell, Scott H.,&Muhlebach, Marianne S..(2013).Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients.JOURNAL OF CYSTIC FIBROSIS,12(4),390-398. |
MLA | Ghio, Andrew J.,et al."Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients".JOURNAL OF CYSTIC FIBROSIS 12.4(2013):390-398. |
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