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DOI | 10.1371/journal.pone.0069518 |
Sublethal Microcystin Exposure and Biochemical Outcomes among Hemodialysis Patients | |
Hilborn, Elizabeth D.1; Soares, Raquel M.2; Servaites, Jerome C.3; Delgado, Alvima G.2; Magalhaes, Valeria F.2; Carmichael, Wayne W.3; Azevedo, Sandra M. F. O.2 | |
发表日期 | 2013-07-24 |
ISSN | 1932-6203 |
卷号 | 8期号:7 |
英文摘要 | Cyanobacteria are commonly-occurring contaminants of surface waters worldwide. Microcystins, potent hepatotoxins, are among the best characterized cyanotoxins. During November, 2001, a group of 44 hemodialysis patients were exposed to microcystins via contaminated dialysate. Serum microcystin concentrations were quantified with enzyme-linked immunosorbent assay which measures free serum microcystin LR equivalents (ME). We describe serum ME concentrations and biochemical outcomes among a subset of patients during 8 weeks following exposure. Thirteen patients were included; 6 were males, patients' median age was 45 years (range 16-80), one was seropositive for hepatitis B surface antigen. The median serum ME concentration was 0.33 ng/mL (range:,0.16-0.96). One hundred thirty nine blood samples were collected following exposure. Patients' biochemical outcomes varied, but overall indicated a mixed liver injury. Linear regression evaluated each patient's weekly mean biochemical outcome with their maximum serum ME concentration; a measure of the extrinsic pathway of clotting function, prothrombin time, was negatively and significantly associated with serum ME concentrations. This group of exposed patients' biochemical outcomes display evidence of a mixed liver injury temporally associated with microcystin exposure. Interpretation of biochemical outcomes are complicated by the study population's underlying chronic disease status. It is clear that dialysis patients are a distinct 'at risk' group for cyanotoxin exposures due to direct intravenous exposure to dialysate prepared from surface drinking water supplies. Careful monitoring and treatment of water supplies used to prepare dialysate is required to prevent future cyanotoxin exposure events. |
语种 | 英语 |
WOS记录号 | WOS:000322167900079 |
来源期刊 | PLOS ONE
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/59406 |
作者单位 | 1.US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA; 2.Univ Fed Rio de Janeiro, Lab Ecophysiol & Toxicol Cyanobacteria, Carlos Chagas Filho Biophys Inst, Rio De Janeiro, Brazil; 3.Wright State Univ, Dept Biol Sci, Dayton, OH 45435 USA |
推荐引用方式 GB/T 7714 | Hilborn, Elizabeth D.,Soares, Raquel M.,Servaites, Jerome C.,et al. Sublethal Microcystin Exposure and Biochemical Outcomes among Hemodialysis Patients[J]. 美国环保署,2013,8(7). |
APA | Hilborn, Elizabeth D..,Soares, Raquel M..,Servaites, Jerome C..,Delgado, Alvima G..,Magalhaes, Valeria F..,...&Azevedo, Sandra M. F. O..(2013).Sublethal Microcystin Exposure and Biochemical Outcomes among Hemodialysis Patients.PLOS ONE,8(7). |
MLA | Hilborn, Elizabeth D.,et al."Sublethal Microcystin Exposure and Biochemical Outcomes among Hemodialysis Patients".PLOS ONE 8.7(2013). |
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