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DOI10.1016/j.taap.2018.03.027
TRPA1 mediates the cardiac effects of acrolein through parasympathetic dominance but also sympathetic modulation in mice
Kurhanewicz, Nicole1; Ledbetter, Allen2; Farraj, Aimen2; Hazari, Mehdi2
发表日期2018-05-15
ISSN0041-008X
卷号347页码:104-114
英文摘要

Numerous studies have demonstrated that short-term air pollution exposure causes cardiac autonomic imbalance as measured by heart rate variability (HRV). We previously showed that a single exposure to acrolein, a ubiquitous gaseous component of air pollution, not only causes autonomic imbalance, but also increases arrhythmia through transient receptor potential A1 (TRPA1) cation channels. Thus, the goal of this study was to characterize acrolein-induced autonomic changes in both normal and TRPA1-knockout mice (KO). Conscious, unrestrained C57BL/6 (WT) and KO mice were exposed to 3 ppm acrolein for 3 h. Separate groups were treated with either atenolol (sympathetic blocker), atropine (parasympathetic blocker) or hexamethonium (autonomic neuro-transmission blocker), immediately before exposure. Electrocardiogram (ECG) and heart rate (HR) were recorded continuously before, during and after exposure. Exposure to acrolein produced significant increases in standard deviation of normal-to-normal R-R intervals (SDNN), Root Mean Square of the Successive Differences (RMSSD) and Low-Frequency (LF), as well as an increase in arrhythmia in WT mice. Treatment with atenolol reduced this response while atropine enhanced it, and both drugs blocked the acrolein-induced increase in arrhythmia; hexamethonium had no effect. On the other hand, neither acrolein nor any drug had an effect in the KO mice. Thus, acrolein-induced HRV responses appear to be mediated by a combined parasympathetic and sympathetic modulation. KO mice did not demonstrate any increases in HRV with exposure to acrolein. These data demonstrate that the cardiac effects of irritant air pollutants likely involve disruption of homeostatic balance and altered regulation even in healthy animals.


英文关键词Acrolein;Cardiac;Autonomic nervous system;Heart rate variability;Arrhythmia;Whole body plethysmography
语种英语
WOS记录号WOS:000431165000011
来源期刊TOXICOLOGY AND APPLIED PHARMACOLOGY
来源机构美国环保署
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/58591
作者单位1.Univ N Carolina, Sch Med, Curriciulm Toxicol, Chapel Hill, NC 27599 USA;
2.US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA
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GB/T 7714
Kurhanewicz, Nicole,Ledbetter, Allen,Farraj, Aimen,et al. TRPA1 mediates the cardiac effects of acrolein through parasympathetic dominance but also sympathetic modulation in mice[J]. 美国环保署,2018,347:104-114.
APA Kurhanewicz, Nicole,Ledbetter, Allen,Farraj, Aimen,&Hazari, Mehdi.(2018).TRPA1 mediates the cardiac effects of acrolein through parasympathetic dominance but also sympathetic modulation in mice.TOXICOLOGY AND APPLIED PHARMACOLOGY,347,104-114.
MLA Kurhanewicz, Nicole,et al."TRPA1 mediates the cardiac effects of acrolein through parasympathetic dominance but also sympathetic modulation in mice".TOXICOLOGY AND APPLIED PHARMACOLOGY 347(2018):104-114.
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