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DOI10.1021/acs.est.5b05648
Application of Biologically Based Lumping To Investigate the Toxicokinetic Interactions of a Complex Gasoline Mixture
Jasper, Micah N.; Martin, Sheppard A.; Oshiro, Wendy M.; Ford, Jermaine; Bushnell, Philip J.; El-Masri, Hisham
发表日期2016-03-15
ISSN0013-936X
卷号50期号:6页码:3231-3238
英文摘要

People are often exposed to complex mixtures of environmental chemicals such as gasoline) tobacco smoke, water contaminants, or food additives. We developed an approach that applies chemical lumping methods to complex mixtures, in this case gasoline, based on biologically relevant parameters used in physiologically based pharmacokinetic (PBPK) modeling. Inhalation exposures were performed with rats to evaluate the performance of our PBPK. model and chemical lumping method. There were 109 chemicals identified and quantified in the vapor in the chamber. The time-course toxicokinetic profiles of. 10 target chemicals were also determined from blood samples collected during and following the in viva experiments. A general PBPK model was used to compare the experimental data to the simulated values of blood concentration for 10 target chemicals with various numbers of lumps, iteratively increasing from 0 to 99. Large reductions in simulation error were gained by incorporating enzymatic chemical interactions; in comparison to simulating the individual chemicals separately. The error was further reduced by lumping the 99 nontarget chemicals. The same biologically based lumping approach can be used to simplify any complex mixture with tens, hundreds, or, thousands of constituents.


语种英语
WOS记录号WOS:000372392100053
来源期刊ENVIRONMENTAL SCIENCE & TECHNOLOGY
来源机构美国环保署
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/58000
作者单位US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27709 USA
推荐引用方式
GB/T 7714
Jasper, Micah N.,Martin, Sheppard A.,Oshiro, Wendy M.,et al. Application of Biologically Based Lumping To Investigate the Toxicokinetic Interactions of a Complex Gasoline Mixture[J]. 美国环保署,2016,50(6):3231-3238.
APA Jasper, Micah N.,Martin, Sheppard A.,Oshiro, Wendy M.,Ford, Jermaine,Bushnell, Philip J.,&El-Masri, Hisham.(2016).Application of Biologically Based Lumping To Investigate the Toxicokinetic Interactions of a Complex Gasoline Mixture.ENVIRONMENTAL SCIENCE & TECHNOLOGY,50(6),3231-3238.
MLA Jasper, Micah N.,et al."Application of Biologically Based Lumping To Investigate the Toxicokinetic Interactions of a Complex Gasoline Mixture".ENVIRONMENTAL SCIENCE & TECHNOLOGY 50.6(2016):3231-3238.
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