Climate Change Data Portal
DOI | 10.1073/pnas.1304291110 |
Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature | |
Kokolus, Kathleen M.1; Capitano, Maegan L.1; Lee, Chen-Ting1; Eng, Jason W. -L.1; Waight, Jeremy D.1; Hylander, Bonnie L.1; Sexton, Sandra2; Hong, Chi-Chen3; Gordon, Christopher J.4; Abrams, Scott I.1; Repasky, Elizabeth A.1 | |
发表日期 | 2013-12-10 |
ISSN | 0027-8424 |
卷号 | 110期号:50页码:20176-20181 |
英文摘要 | We show here that fundamental aspects of antitumor immunity in mice are significantly influenced by ambient housing temperature. Standard housing temperature for laboratory mice in research facilities is mandated to be between 20-26 degrees C; however, these subthermoneutral temperatures cause mild chronic cold stress, activating thermogenesis to maintain normal body temperature. When stress is alleviated by housing at thermoneutral ambient temperature (30-31 degrees C), we observe a striking reduction in tumor formation, growth rate and metastasis. This improved control of tumor growth is dependent upon the adaptive immune system. We observe significantly increased numbers of antigen-specific CD8(+) T lymphocytes and CD8(+) T cells with an activated phenotype in the tumor microenvironment at thermoneutrality. At the same time there is a significant reduction in numbers of immunosuppressive MDSCs and regulatory T lymphocytes. Notably, in temperature preference studies, tumor-bearing mice select a higher ambient temperature than non-tumor-bearing mice, suggesting that tumor-bearing mice experience a greater degree of cold-stress. Overall, our data raise the hypothesis that suppression of antitumor immunity is an outcome of cold stress-induced thermogenesis. Therefore, the common approach of studying immunity against tumors in mice housed only at standard room temperature may be limiting our understanding of the full potential of the antitumor immune response. |
英文关键词 | murine tumor models;metabolism |
语种 | 英语 |
WOS记录号 | WOS:000328061700055 |
来源期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
![]() |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/57921 |
作者单位 | 1.Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY 14263 USA; 2.Roswell Pk Canc Inst, Dept Anim Resources, Buffalo, NY 14263 USA; 3.Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA; 4.US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27709 USA |
推荐引用方式 GB/T 7714 | Kokolus, Kathleen M.,Capitano, Maegan L.,Lee, Chen-Ting,et al. Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature[J]. 美国环保署,2013,110(50):20176-20181. |
APA | Kokolus, Kathleen M..,Capitano, Maegan L..,Lee, Chen-Ting.,Eng, Jason W. -L..,Waight, Jeremy D..,...&Repasky, Elizabeth A..(2013).Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,110(50),20176-20181. |
MLA | Kokolus, Kathleen M.,et al."Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110.50(2013):20176-20181. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。