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Stable isotopes are a primary tool for inferring past temperature changes and atmospheric moisture variability from ice cores. A 33 m ice core representing the period 1850-2004 was retrieved from the Tanggula Mountains, central Tibetan Plateau (5743 m a.s.l.), in August 2005. Annual average stable isotope (delta O-18, delta D) values generally increase during the period, while the second-order parameter of deuterium excess (d-excess) generally decreases. High annual average d-excess values (18.2 parts per thousand) throughout the ice core suggest a significant contribution of continental recycled moisture. d-excess values shift from relatively higher values during 1850-1940 to lower values since the 1940s. Annual isotope values and reconstructed accumulation are compared with climate indices, local station temperature records and northern India monsoon precipitation. Significant correlation is observed between delta O-18 and the Southern Oscillation, NINO3.4 and Dipole Mode indices. Annual average d-excess values revealed a significant negative correlation with the Dipole Mode index. Results suggest a relatively greater contribution of westerly-dominated continental moisture prior to the 1940s and an increase in the contribution of moisture evaporated under more humid conditions since the 1940s.