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| DOI | 10.1016/j.dci.2024.105161 |
| Climate change can impair bacterial pathogen defences in sablefish via hypoxia-mediated effects on adaptive immunity | |
| 发表日期 | 2024 |
| ISSN | 0145-305X |
| EISSN | 1879-0089 |
| 起始页码 | 156 |
| 卷号 | 156 |
| 英文摘要 | Low -oxygen levels (hypoxia) in aquatic habitats are becoming more common because of global warming and eutrophication. However, the effects on the health/disease status of fishes, the world's largest group of vertebrates, are unclear. Therefore, we assessed how long-term hypoxia affected the immune function of sablefish, an ecologically and economically important North Pacific species, including the response to a formalin-killed Aeromonas salmonicida bacterin. Sablefish were held at normoxia or hypoxia (100% or 40% air saturated seawater, respectively) for 6-16 weeks, while we measured a diverse array of immunological traits. Given that the sablefish is a non -model organism, this involved the development of a species -specific methodological toolbox comprised of qPCR primers for 16 key immune genes, assays for blood antibacterial defences, the assessment of blood immunoglobulin (IgM) levels with ELISA, and flow cytometry and confocal microscopy techniques. We show that innate immune parameters were typically elevated in response to the bacterial antigens, but were not substantially affected by hypoxia. In contrast, hypoxia completely prevented the similar to 1.5 -fold increase in blood IgM level that was observed under normoxic conditions following bacterin exposure, implying a serious impairment of adaptive immunity. Since the sablefish is naturally hypoxia tolerant, our results demonstrate that climate change -related deoxygenation may be a serious threat to the immune competency of fishes. |
| 英文关键词 | Sablefish ( Anoplopoma fimbria ); Chronic hypoxia; Innate immunity; Adaptive immunity; Bacterial pathogen; Climate change |
| 语种 | 英语 |
| WOS研究方向 | Fisheries ; Immunology ; Veterinary Sciences ; Zoology |
| WOS类目 | Fisheries ; Immunology ; Veterinary Sciences ; Zoology |
| WOS记录号 | WOS:001235309300001 |
| 来源期刊 | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
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| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/309791 |
| 作者单位 | Memorial University Newfoundland; Memorial University Newfoundland; University of Wisconsin System; University of Wisconsin Milwaukee; Fisheries & Oceans Canada; Norwegian University of Science & Technology (NTNU); Fisheries & Oceans Canada |
| 推荐引用方式 GB/T 7714 | . Climate change can impair bacterial pathogen defences in sablefish via hypoxia-mediated effects on adaptive immunity[J],2024,156. |
| APA | (2024).Climate change can impair bacterial pathogen defences in sablefish via hypoxia-mediated effects on adaptive immunity.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,156. |
| MLA | "Climate change can impair bacterial pathogen defences in sablefish via hypoxia-mediated effects on adaptive immunity".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 156(2024). |
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