气候变化领域集成服务门户(CCPortal): Anticoagulant Rodenticide Toxicity in Terrestrial Raptors: Tools to Estimate the Impact on Populations in North America and Globally

CCPortal

DOI	10.1002/etc.5829
	Anticoagulant Rodenticide Toxicity in Terrestrial Raptors: Tools to Estimate the Impact on Populations in North America and Globally
	Elliott, John E.; Silverthorn, Veronica; English, Simon; Mineau, Pierre; Hindmarch, Sofi; Thomas, Philippe J.; Lee, Sandi; Bowes, Victoria; Redford, Tony; Maisonneuve, France; Okoniewski, Joseph
发表日期	2024
ISSN	0730-7268
EISSN	1552-8618
英文摘要	Anticoagulant rodenticides (ARs) have caused widespread contamination and poisoning of predators and scavengers. The diagnosis of toxicity proceeds from evidence of hemorrhage, and subsequent detection of residues in liver. Many factors confound the assessment of AR poisoning, particularly exposure dose, timing and frequency of exposure, and individual and taxon-specific variables. There is a need, therefore, for better AR toxicity criteria. To respond, we compiled a database of second-generation anticoagulant rodenticide (SGAR) residues in liver and postmortem evaluations of 951 terrestrial raptor carcasses from Canada and the United States, 1989 to 2021. We developed mixed-effects logistic regression models to produce specific probability curves of the toxicity of n-ary sumation SGARs at the taxonomic level of the family, and separately for three SGARs registered in North America, brodifacoum, bromadiolone, and difethialone. The n-ary sumation SGAR threshold concentrations for diagnosis of coagulopathy at 0.20 probability of risk were highest for strigid owls (15 ng g-1) lower and relatively similar for accipitrid hawks and eagles (8.2 ng g-1) and falcons (7.9 ng g-1), and much lower for tytonid barn owls (0.32 ng g-1). These values are lower than those we found previously, due to compilation and use of a larger database with a mix of species and source locations, and also to refinements in the statistical methods. Our presentation of results on the family taxonomic level should aid in the global applicability of the numbers. We also collated a subset of 440 single-compound exposure events and determined the probability of SGAR-poisoning symptoms as a function of SGAR concentration, which we then used to estimate relative SGAR toxicity and toxic equivalence factors: difethialone, 1, brodifacoum, 0.8, and bromadiolone, 0.5. Environ Toxicol Chem 2024;00:1-11. (c) 2024 His Majesty the King in Right of Canada and The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC Reproduced with the permission of the Minister of Environment and Climate Change Canada.
英文关键词	Anticoagulant rodenticides; Liver residues; Toxicity threshold; Raptors; Nontarget exposure; Secondary poisoning; Ecotoxicology; Generalized linear mixed model (GLMM)
语种	英语
WOS研究方向	Environmental Sciences & Ecology ; Toxicology
WOS类目	Environmental Sciences ; Toxicology
WOS记录号	WOS:001174501000001
来源期刊	ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/305110
作者单位	Environment & Climate Change Canada; University of British Columbia; Simon Fraser University; University of British Columbia; Carleton University; Environment & Climate Change Canada; Canadian Wildlife Service; National Wildlife Research Centre - Canada
推荐引用方式 GB/T 7714	Elliott, John E.,Silverthorn, Veronica,English, Simon,et al. Anticoagulant Rodenticide Toxicity in Terrestrial Raptors: Tools to Estimate the Impact on Populations in North America and Globally[J],2024.
APA	Elliott, John E..,Silverthorn, Veronica.,English, Simon.,Mineau, Pierre.,Hindmarch, Sofi.,...&Okoniewski, Joseph.(2024).Anticoagulant Rodenticide Toxicity in Terrestrial Raptors: Tools to Estimate the Impact on Populations in North America and Globally.ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY.
MLA	Elliott, John E.,et al."Anticoagulant Rodenticide Toxicity in Terrestrial Raptors: Tools to Estimate the Impact on Populations in North America and Globally".ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2024).