气候变化领域集成服务门户(CCPortal): Nosocomial infections by diverse carbapenemase-producing Aeromonas hydrophila associated with combination of plumbing issues and heat waves

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DOI	10.1016/j.ajic.2023.09.013
	Nosocomial infections by diverse carbapenemase-producing Aeromonas hydrophila associated with combination of plumbing issues and heat waves
	Gray, Hannah K.; Bisht, Anjali; Caldera, J. R.; Braegger, Nicole M. Fossas; Cambou, Mary C.; Sakona, Ashlyn N.; Beaird, Omer E.; Uslan, Daniel Z.; Walton, Shaunte C.; Yang, Shangxin
发表日期	2024
ISSN	0196-6553
EISSN	1527-3296
起始页码	52
结束页码	3
卷号	52 期号:3
英文摘要	Background: Aquatic opportunistic pathogen Aeromonas hydrophila, known to persist in low -nutrient chlorinated waters, can cause life -threatening infections. Two intensive care units experienced a cluster of Aeromonas infections following outdoor temperature spikes coinciding with recurrent plumbing issues, with fatalities due to severe underlying comorbidities co-occurring with extensively -drug resistant (XDR) Aeromonas. Methods: We investigated this cluster using whole genome sequencing to assess genetic relatedness of isolates and identify antimicrobial resistance determinants. Three A. hydrophila were isolated from patients staying in or adjacent to rooms with plumbing issues during or immediately after periods of elevated outdoor temperatures. Sinks and faucets were swabbed for culture. Results: All A. hydrophila clinical isolates exhibited carbapenem resistance but were not genetically related. Diverse resistance determinants corresponding to extensively -drug resistant were found, including co-occurring KPC-3 and VIM -2, OXA-232, and chromosomal CphA-like carbapenemase genes, contributing to major treatment challenges. All 3 patients were treated with multiple antibiotic regimens to overcome various carbapenemase classes and expired due to underlying comorbidities. Environmental culture yielded no Aeromonas. Conclusions: While the investigation revealed no singular source of contamination, it supports a possible link between plumbing issues, elevated outdoor temperatures and incidence of nosocomial Aeromonas infections. The diversity of carbapenemase genes detected in these wastewater -derived Aeromonas warrants heightened infection prevention precautions during periods of plumbing problems especially with heat waves. (c) 2023 The Author(s). Published by Elsevier Inc. on behalf of Association for Professionals in Infection Control and Epidemiology, Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
英文关键词	Drug resistance; Climate change; Outbreak investigation; Whole-genome sequencing
语种	英语
WOS研究方向	Public, Environmental & Occupational Health ; Infectious Diseases
WOS类目	Public, Environmental & Occupational Health ; Infectious Diseases
WOS记录号	WOS:001193970100001
来源期刊	AMERICAN JOURNAL OF INFECTION CONTROL
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/301357
作者单位	University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles
推荐引用方式 GB/T 7714	Gray, Hannah K.,Bisht, Anjali,Caldera, J. R.,et al. Nosocomial infections by diverse carbapenemase-producing Aeromonas hydrophila associated with combination of plumbing issues and heat waves[J],2024,52(3).
APA	Gray, Hannah K..,Bisht, Anjali.,Caldera, J. R..,Braegger, Nicole M. Fossas.,Cambou, Mary C..,...&Yang, Shangxin.(2024).Nosocomial infections by diverse carbapenemase-producing Aeromonas hydrophila associated with combination of plumbing issues and heat waves.AMERICAN JOURNAL OF INFECTION CONTROL,52(3).
MLA	Gray, Hannah K.,et al."Nosocomial infections by diverse carbapenemase-producing Aeromonas hydrophila associated with combination of plumbing issues and heat waves".AMERICAN JOURNAL OF INFECTION CONTROL 52.3(2024).