气候变化领域集成服务门户(CCPortal): The special adaptation to hypoxia facilitated the expansion of the Asian house rat (Rattus tanezumi) into Tibet but not other Rattus species

CCPortal

DOI	10.1111/1749-4877.12829
	The special adaptation to hypoxia facilitated the expansion of the Asian house rat (Rattus tanezumi) into Tibet but not other Rattus species
	Cao, Ruidong; Zhang, Mingyu; Chen, Yi; Hou, Guanmei; Liu, Quansheng; Zhang, Jianxu; Zhang, Yaohua
发表日期	2024
ISSN	1749-4877
EISSN	1749-4869
英文摘要	Rattus species are thought to live only at altitudes less than 2500 m, but the Asian house rat (R. tanezumi) (RT) has recently expanded to altitudes greater than 3500 m in China. Other Rattus species, especially brown rats (R. norvegicus) (RN), still reach only low altitudes on the Tibetan Plateau. Comparative genomics revealed the positive selection of hypoxia-inducible transcription factors 1 and 2 (HIFs) in RT, with the rapid evolution of HIF pathway genes in RT and Mus musculus (MM) but not RN or R. rattus. Population genomics revealed that genes associated with energy metabolism and oxygen transport were positively selected in RT compared with the other four Rattus species, and two specific substitutions (arginine 31 serine and leucine 33 methionine) were identified in the hemoglobin subunit beta (HBB) in RT. The above results suggested that RT possesses unique genetic adaptations to hypoxia, which was further confirmed by behavioral experiments on RT and RN. Normobaric hypoxia significantly reduced locomotion in RN but not in RT. Moreover, through intraspecific transcriptome analysis, the expression of Hbb and genes related to angiogenesis, oxygen transport, and glycolysis was upregulated, and the expression of genes associated with immunological functions in the liver, lungs, and/or sperm was downregulated in RT compared to those in RN. Interspecific transcriptome analysis further revealed that HIF-1 alpha plays a role in modulating the hypoxic adaptation of RT rather than RN. Our work provides genomic, behavioral, and physiological insights into why RT, but not other Rattus species, could invade the Tibetan Plateau.
英文关键词	genomic signature; hypoxia; physiological plasticity; Rattus tanezumi; transcriptome
语种	英语
WOS研究方向	Zoology
WOS类目	Zoology
WOS记录号	WOS:001216729500001
来源期刊	INTEGRATIVE ZOOLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/301133
作者单位	Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Guangdong Academy of Sciences; Institute of Zoology, Guangdong Academy of Sciences; Chinese Academy of Sciences; Institute of Zoology, CAS; Anhui University
推荐引用方式 GB/T 7714	Cao, Ruidong,Zhang, Mingyu,Chen, Yi,et al. The special adaptation to hypoxia facilitated the expansion of the Asian house rat (Rattus tanezumi) into Tibet but not other Rattus species[J],2024.
APA	Cao, Ruidong.,Zhang, Mingyu.,Chen, Yi.,Hou, Guanmei.,Liu, Quansheng.,...&Zhang, Yaohua.(2024).The special adaptation to hypoxia facilitated the expansion of the Asian house rat (Rattus tanezumi) into Tibet but not other Rattus species.INTEGRATIVE ZOOLOGY.
MLA	Cao, Ruidong,et al."The special adaptation to hypoxia facilitated the expansion of the Asian house rat (Rattus tanezumi) into Tibet but not other Rattus species".INTEGRATIVE ZOOLOGY (2024).